The influence of central corneal thickness on progression of normotensive glaucoma
Objectives. To verify whether there is a relation between central corneal thickness (CCT) and progression of normotensive glaucoma (NTG), to assess the impact of early changes in the visual field on their progression in time. Methods and Patients. The sample consisted of two groups of patients with...
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2021-03-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202101-0012_the-influence-of-central-corneal-thickness-on-progression-of-normotensive-glaucoma.php |
| _version_ | 1818576339163152384 |
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| author | Elena Nutterova Klara Maresova Jan Lestak |
| author_facet | Elena Nutterova Klara Maresova Jan Lestak |
| author_sort | Elena Nutterova |
| collection | DOAJ |
| description | Objectives. To verify whether there is a relation between central corneal thickness (CCT) and progression of normotensive glaucoma (NTG), to assess the impact of early changes in the visual field on their progression in time. Methods and Patients. The sample consisted of two groups of patients with NTG. In the first group there were 50 eyes of 25 persons (15 females and 10 males) average age 63 years who had been treated with prostaglandins. The second group consisted of 50 eyes of 25 persons (16 females and 9 males) average age of 62 years who had had no local therapy. All patients were cardiologically compensated and had no other internal or neurological disease. Visual acuity was 1.0 with a possible correction (less than ±3 dioptres) in all patients. The IOP ranged between 10-15 mmHg in all patients. If hypotensive ophthalmological therapy was initiated, it had been stable for the last five years. In all patients, we monitored CCT, excavation in the papilla (c/d), pattern defect (PD) and overall defect (OD) of the visual field. In 2013, changes in the visual fields were approximately the same in all patients. We compared the results of the visual fields after five years, i.e. the results were obtained in 2018. CCT was measured, using the ultrasound pachymeter Tomey SP-100. PD and OD of the visual field using the glaucoma fast threshold program with the MEDMONT M 700 device. For statistical comparison, we used the paired t test and correlation analysis. Results. In both groups, we found progression of PD in time (P=0.0000, P=0.0001, respectively). In the patients treated with prostaglandins, OD had not statistically significantly changed (P=0.49) in contrast to the untreated patients (P=0.001). There was no statistically significant relation between CCT and PD in any of the groups. It was similar between the CCT and OD. In the treated NTG patients, we found a weak correlation between the changes in PD in time (r=0.2846, P=0.0438) and moderately strong relation for OD (r=-0.63). The finding was similar in untreated patients PD (r=-0.2, P=0.162) and OD (r=-0.443, P=0.001). Conclusion. We found no relationship between progression of changes in the visual fields in CCT. Progression of changes in the visual fields was higher in patients who had more advanced changes at the beginning of observation. The untreated patients had progression of changes in the visual fields both in PD and OD in contrast to those who were taking prostaglandins and presented changes only in PD. |
| first_indexed | 2024-12-16T06:12:27Z |
| format | Article |
| id | doaj.art-6797bdb34af84785b0dec6fe0c10d2a4 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-16T06:12:27Z |
| publishDate | 2021-03-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-6797bdb34af84785b0dec6fe0c10d2a42022-12-21T22:41:22ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212021-03-011651808310.5507/bp.2019.057bio-202101-0012The influence of central corneal thickness on progression of normotensive glaucomaElena Nutterova0Klara Maresova1Jan Lestak2Eye Clinic JL FBMI CTU Prague, Czech RepublicDepartment of Ophthalmology, Faculty of Medicine, Palacky University Olomouc, Czech RepublicEye Clinic JL FBMI CTU Prague, Czech RepublicObjectives. To verify whether there is a relation between central corneal thickness (CCT) and progression of normotensive glaucoma (NTG), to assess the impact of early changes in the visual field on their progression in time. Methods and Patients. The sample consisted of two groups of patients with NTG. In the first group there were 50 eyes of 25 persons (15 females and 10 males) average age 63 years who had been treated with prostaglandins. The second group consisted of 50 eyes of 25 persons (16 females and 9 males) average age of 62 years who had had no local therapy. All patients were cardiologically compensated and had no other internal or neurological disease. Visual acuity was 1.0 with a possible correction (less than ±3 dioptres) in all patients. The IOP ranged between 10-15 mmHg in all patients. If hypotensive ophthalmological therapy was initiated, it had been stable for the last five years. In all patients, we monitored CCT, excavation in the papilla (c/d), pattern defect (PD) and overall defect (OD) of the visual field. In 2013, changes in the visual fields were approximately the same in all patients. We compared the results of the visual fields after five years, i.e. the results were obtained in 2018. CCT was measured, using the ultrasound pachymeter Tomey SP-100. PD and OD of the visual field using the glaucoma fast threshold program with the MEDMONT M 700 device. For statistical comparison, we used the paired t test and correlation analysis. Results. In both groups, we found progression of PD in time (P=0.0000, P=0.0001, respectively). In the patients treated with prostaglandins, OD had not statistically significantly changed (P=0.49) in contrast to the untreated patients (P=0.001). There was no statistically significant relation between CCT and PD in any of the groups. It was similar between the CCT and OD. In the treated NTG patients, we found a weak correlation between the changes in PD in time (r=0.2846, P=0.0438) and moderately strong relation for OD (r=-0.63). The finding was similar in untreated patients PD (r=-0.2, P=0.162) and OD (r=-0.443, P=0.001). Conclusion. We found no relationship between progression of changes in the visual fields in CCT. Progression of changes in the visual fields was higher in patients who had more advanced changes at the beginning of observation. The untreated patients had progression of changes in the visual fields both in PD and OD in contrast to those who were taking prostaglandins and presented changes only in PD.https://biomed.papers.upol.cz/artkey/bio-202101-0012_the-influence-of-central-corneal-thickness-on-progression-of-normotensive-glaucoma.phpnormotensive glaucomacentral corneal thicknessvisual fieldpattern defectoverall defect |
| spellingShingle | Elena Nutterova Klara Maresova Jan Lestak The influence of central corneal thickness on progression of normotensive glaucoma Biomedical Papers normotensive glaucoma central corneal thickness visual field pattern defect overall defect |
| title | The influence of central corneal thickness on progression of normotensive glaucoma |
| title_full | The influence of central corneal thickness on progression of normotensive glaucoma |
| title_fullStr | The influence of central corneal thickness on progression of normotensive glaucoma |
| title_full_unstemmed | The influence of central corneal thickness on progression of normotensive glaucoma |
| title_short | The influence of central corneal thickness on progression of normotensive glaucoma |
| title_sort | influence of central corneal thickness on progression of normotensive glaucoma |
| topic | normotensive glaucoma central corneal thickness visual field pattern defect overall defect |
| url | https://biomed.papers.upol.cz/artkey/bio-202101-0012_the-influence-of-central-corneal-thickness-on-progression-of-normotensive-glaucoma.php |
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