Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders
The evolution of humans brought about a co-occurring evolution of the human brain, which is far larger and more complex than that of many other organisms. The brain has evolved characteristically in humans in many respects, including macro-and micro-anatomical changes in the brain structure, changes...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.871979/full |
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| author | Koichiro Irie Koichiro Irie Miyuki Doi Noriyoshi Usui Noriyoshi Usui Noriyoshi Usui Noriyoshi Usui Shoichi Shimada Shoichi Shimada Shoichi Shimada Shoichi Shimada |
| author_facet | Koichiro Irie Koichiro Irie Miyuki Doi Noriyoshi Usui Noriyoshi Usui Noriyoshi Usui Noriyoshi Usui Shoichi Shimada Shoichi Shimada Shoichi Shimada Shoichi Shimada |
| author_sort | Koichiro Irie |
| collection | DOAJ |
| description | The evolution of humans brought about a co-occurring evolution of the human brain, which is far larger and more complex than that of many other organisms. The brain has evolved characteristically in humans in many respects, including macro-and micro-anatomical changes in the brain structure, changes in gene expression, and cell populations and ratios. These characteristics are essential for the execution of higher functions, such as sociality, language, and cognition, which express humanity, and are thought to have been acquired over evolutionary time. However, with the acquisition of higher functions also comes the risk of the disease in which they fail. This review focuses on human brain evolution and neurodevelopmental disorders (NDDs) and discusses brain development, molecular evolution, and human brain evolution. Discussing the potential for the development and pathophysiology of NDDs acquired by human brain evolution will provide insights into the acquisition and breakdown of higher functions from a new perspective. |
| first_indexed | 2024-04-13T15:38:48Z |
| format | Article |
| id | doaj.art-67982d9d295045cd827d27efd080b38f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T15:38:48Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-67982d9d295045cd827d27efd080b38f2022-12-22T02:41:12ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-04-011610.3389/fnins.2022.871979871979Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental DisordersKoichiro Irie0Koichiro Irie1Miyuki Doi2Noriyoshi Usui3Noriyoshi Usui4Noriyoshi Usui5Noriyoshi Usui6Shoichi Shimada7Shoichi Shimada8Shoichi Shimada9Shoichi Shimada10Department of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Suita, JapanCenter for Medical Research and Education, Graduate School of Medicine, Osaka University, Suita, JapanDepartment of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Suita, JapanDepartment of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Suita, JapanUnited Graduate School of Child Development, Osaka University, Suita, JapanGlobal Center for Medical Engineering and Informatics, Osaka University, Suita, JapanAddiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, JapanDepartment of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Suita, JapanUnited Graduate School of Child Development, Osaka University, Suita, JapanGlobal Center for Medical Engineering and Informatics, Osaka University, Suita, JapanAddiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, JapanThe evolution of humans brought about a co-occurring evolution of the human brain, which is far larger and more complex than that of many other organisms. The brain has evolved characteristically in humans in many respects, including macro-and micro-anatomical changes in the brain structure, changes in gene expression, and cell populations and ratios. These characteristics are essential for the execution of higher functions, such as sociality, language, and cognition, which express humanity, and are thought to have been acquired over evolutionary time. However, with the acquisition of higher functions also comes the risk of the disease in which they fail. This review focuses on human brain evolution and neurodevelopmental disorders (NDDs) and discusses brain development, molecular evolution, and human brain evolution. Discussing the potential for the development and pathophysiology of NDDs acquired by human brain evolution will provide insights into the acquisition and breakdown of higher functions from a new perspective.https://www.frontiersin.org/articles/10.3389/fnins.2022.871979/fullbrain evolutionmolecular evolutioncomparative genomicshuman brainoligodendrocyteneurodevelopmental disorders (NDDs) |
| spellingShingle | Koichiro Irie Koichiro Irie Miyuki Doi Noriyoshi Usui Noriyoshi Usui Noriyoshi Usui Noriyoshi Usui Shoichi Shimada Shoichi Shimada Shoichi Shimada Shoichi Shimada Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders Frontiers in Neuroscience brain evolution molecular evolution comparative genomics human brain oligodendrocyte neurodevelopmental disorders (NDDs) |
| title | Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders |
| title_full | Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders |
| title_fullStr | Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders |
| title_full_unstemmed | Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders |
| title_short | Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders |
| title_sort | evolution of the human brain can help determine pathophysiology of neurodevelopmental disorders |
| topic | brain evolution molecular evolution comparative genomics human brain oligodendrocyte neurodevelopmental disorders (NDDs) |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.871979/full |
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