Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases
In addition to adverse health outcomes, neurological disorders have serious societal and economic impacts on patients, their family and society as a whole. There is no definite treatment for these disorders, and current available drugs only slow down the progression of the disease. In recent years,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/14/4852 |
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| author | Shima Masoudi Asil Jyoti Ahlawat Gileydis Guillama Barroso Mahesh Narayan |
| author_facet | Shima Masoudi Asil Jyoti Ahlawat Gileydis Guillama Barroso Mahesh Narayan |
| author_sort | Shima Masoudi Asil |
| collection | DOAJ |
| description | In addition to adverse health outcomes, neurological disorders have serious societal and economic impacts on patients, their family and society as a whole. There is no definite treatment for these disorders, and current available drugs only slow down the progression of the disease. In recent years, application of stem cells has been widely advanced due to their potential of self-renewal and differentiation to different cell types which make them suitable candidates for cell therapy. In particular, this approach offers great opportunities for the treatment of neurodegenerative disorders. However, some major issues related to stem-cell therapy, including their tumorigenicity, viability, safety, metastases, uncontrolled differentiation and possible immune response have limited their application in clinical scales. To address these challenges, a combination of stem-cell therapy with nanotechnology can be a solution. Nanotechnology has the potential of improvement of stem-cell therapy by providing ideal substrates for large scale proliferation of stem cells. Application of nanomaterial in stem-cell culture will be also beneficial to modulation of stem-cell differentiation using nanomedicines. Nanodelivery of functional compounds can enhance the efficiency of neuron therapy by stem cells and development of nanobased techniques for real-time, accurate and long-lasting imaging of stem-cell cycle processes. However, these novel techniques need to be investigated to optimize their efficiency in treatment of neurologic diseases. |
| first_indexed | 2024-03-10T18:28:38Z |
| format | Article |
| id | doaj.art-6798c7675afc4973934377c115446870 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T18:28:38Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-6798c7675afc4973934377c1154468702023-11-20T06:49:03ZengMDPI AGApplied Sciences2076-34172020-07-011014485210.3390/app10144852Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative DiseasesShima Masoudi Asil0Jyoti Ahlawat1Gileydis Guillama Barroso2Mahesh Narayan3The Department of Environmental Science & Engineering, The University of Texas at El Paso, El Paso, TX 79968, USAThe Department of Chemistry & Biochemistry, The University of Texas at El Paso, El Paso, TX 79968, USAThe Department of Chemistry, The University of Havana, Havana 10400, CubaThe Department of Chemistry & Biochemistry, The University of Texas at El Paso, El Paso, TX 79968, USAIn addition to adverse health outcomes, neurological disorders have serious societal and economic impacts on patients, their family and society as a whole. There is no definite treatment for these disorders, and current available drugs only slow down the progression of the disease. In recent years, application of stem cells has been widely advanced due to their potential of self-renewal and differentiation to different cell types which make them suitable candidates for cell therapy. In particular, this approach offers great opportunities for the treatment of neurodegenerative disorders. However, some major issues related to stem-cell therapy, including their tumorigenicity, viability, safety, metastases, uncontrolled differentiation and possible immune response have limited their application in clinical scales. To address these challenges, a combination of stem-cell therapy with nanotechnology can be a solution. Nanotechnology has the potential of improvement of stem-cell therapy by providing ideal substrates for large scale proliferation of stem cells. Application of nanomaterial in stem-cell culture will be also beneficial to modulation of stem-cell differentiation using nanomedicines. Nanodelivery of functional compounds can enhance the efficiency of neuron therapy by stem cells and development of nanobased techniques for real-time, accurate and long-lasting imaging of stem-cell cycle processes. However, these novel techniques need to be investigated to optimize their efficiency in treatment of neurologic diseases.https://www.mdpi.com/2076-3417/10/14/4852nanotechnologystem cellnanoparticleneurodegenerative diseasenanodeliverynanomedicine |
| spellingShingle | Shima Masoudi Asil Jyoti Ahlawat Gileydis Guillama Barroso Mahesh Narayan Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases Applied Sciences nanotechnology stem cell nanoparticle neurodegenerative disease nanodelivery nanomedicine |
| title | Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases |
| title_full | Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases |
| title_fullStr | Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases |
| title_full_unstemmed | Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases |
| title_short | Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases |
| title_sort | application of nanotechnology in stem cell based therapy of neurodegenerative diseases |
| topic | nanotechnology stem cell nanoparticle neurodegenerative disease nanodelivery nanomedicine |
| url | https://www.mdpi.com/2076-3417/10/14/4852 |
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