Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs
Objective(s): In this research, zeolite X and zeolite Y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. Materials and Methods: A soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. Gravimetric m...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2014-05-01
|
| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_2783_cd932096adcd5ec8b21cfe2eb3e80875.html |
| _version_ | 1819035326430052352 |
|---|---|
| author | Elham Khodaverdi Reza Honarmandi Mona Alibolandi Roxana Rafatpanah Baygi Farzin Hadizadeh Gholamhossein Zohuri |
| author_facet | Elham Khodaverdi Reza Honarmandi Mona Alibolandi Roxana Rafatpanah Baygi Farzin Hadizadeh Gholamhossein Zohuri |
| author_sort | Elham Khodaverdi |
| collection | DOAJ |
| description | Objective(s): In this research, zeolite X and zeolite Y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. Materials and Methods: A soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. Gravimetric methods and IR spectra of prepared formulations were used to assess drug loading efficiencies into zeolite structures. Scanning Electron Microscopy (SEM) was also utilized to determine morphologies changes in synthetic zeolites after drug loading. At the next stage, dissolution studies were used to predict the in vivo performance of prepared formulations at HCl 0.1 N and PBS pH 6.5 as simulated gastric fluid (SGF) and simulated intestine fluid (SIF), respectively. Results: Drug loadings of prepared formulations was determined between 24-26 % w/w. Dissolution tests at SGF were shown that zeolites could retain acidic model drugs in their porous structures and can be able to limit their release into the stomach. On the other hand, all prepared formulations completely released model drugs during 3 hr in simulated intestine fluid. Conclusion: Obtained results indicated zeolites could potentially be able to release indomethacin and ibuprofen in a sustained and controlled manner and reduced adverse effects commonly accompanying oral administrations of NSAIDs. |
| first_indexed | 2024-12-21T07:47:51Z |
| format | Article |
| id | doaj.art-6798eefe4b924a64a186cc611605ad61 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-21T07:47:51Z |
| publishDate | 2014-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-6798eefe4b924a64a186cc611605ad612022-12-21T19:11:10ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742014-05-011753373432783Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugsElham Khodaverdi0Reza Honarmandi1Mona Alibolandi2Roxana Rafatpanah Baygi3Farzin Hadizadeh4Gholamhossein Zohuri5Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 2 Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranBiotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranBiotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Chemistry, Faculty of Science, Ferdowsi University, Mashhad, IranObjective(s): In this research, zeolite X and zeolite Y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. Materials and Methods: A soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. Gravimetric methods and IR spectra of prepared formulations were used to assess drug loading efficiencies into zeolite structures. Scanning Electron Microscopy (SEM) was also utilized to determine morphologies changes in synthetic zeolites after drug loading. At the next stage, dissolution studies were used to predict the in vivo performance of prepared formulations at HCl 0.1 N and PBS pH 6.5 as simulated gastric fluid (SGF) and simulated intestine fluid (SIF), respectively. Results: Drug loadings of prepared formulations was determined between 24-26 % w/w. Dissolution tests at SGF were shown that zeolites could retain acidic model drugs in their porous structures and can be able to limit their release into the stomach. On the other hand, all prepared formulations completely released model drugs during 3 hr in simulated intestine fluid. Conclusion: Obtained results indicated zeolites could potentially be able to release indomethacin and ibuprofen in a sustained and controlled manner and reduced adverse effects commonly accompanying oral administrations of NSAIDs.http://ijbms.mums.ac.ir/pdf_2783_cd932096adcd5ec8b21cfe2eb3e80875.htmlControlled drug delivery-systemsIbuprofenIndomethacinZeolite |
| spellingShingle | Elham Khodaverdi Reza Honarmandi Mona Alibolandi Roxana Rafatpanah Baygi Farzin Hadizadeh Gholamhossein Zohuri Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs Iranian Journal of Basic Medical Sciences Controlled drug delivery-systems Ibuprofen Indomethacin Zeolite |
| title | Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs |
| title_full | Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs |
| title_fullStr | Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs |
| title_full_unstemmed | Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs |
| title_short | Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs |
| title_sort | evaluation of synthetic zeolites as oral delivery vehicle for anti inflammatory drugs |
| topic | Controlled drug delivery-systems Ibuprofen Indomethacin Zeolite |
| url | http://ijbms.mums.ac.ir/pdf_2783_cd932096adcd5ec8b21cfe2eb3e80875.html |
| work_keys_str_mv | AT elhamkhodaverdi evaluationofsyntheticzeolitesasoraldeliveryvehicleforantiinflammatorydrugs AT rezahonarmandi evaluationofsyntheticzeolitesasoraldeliveryvehicleforantiinflammatorydrugs AT monaalibolandi evaluationofsyntheticzeolitesasoraldeliveryvehicleforantiinflammatorydrugs AT roxanarafatpanahbaygi evaluationofsyntheticzeolitesasoraldeliveryvehicleforantiinflammatorydrugs AT farzinhadizadeh evaluationofsyntheticzeolitesasoraldeliveryvehicleforantiinflammatorydrugs AT gholamhosseinzohuri evaluationofsyntheticzeolitesasoraldeliveryvehicleforantiinflammatorydrugs |