Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattle
Objective. Due to the importance of controlling ectoparasites, associated with the necessity of technical knowledge on the safety of topical treatment with organophosphates, pyrethroids and piperonyl butoxide to the animal organism, this bioassay was carried out to evaluate the clinical safety of th...
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| Format: | Article |
| Language: | English |
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Universidad de Cordoba
2015-11-01
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| Series: | Revista MVZ Cordoba |
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| Online Access: | http://revistas.unicordoba.edu.co/revistamvz/mvz-203s/pdf/v20Supl1a3.pdf |
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| author | Alessandra C Moraes Ed JR Prado Vanessa P Faria Thais MS Gírio Wilson G Manrique Marco AA Belo |
| author_facet | Alessandra C Moraes Ed JR Prado Vanessa P Faria Thais MS Gírio Wilson G Manrique Marco AA Belo |
| author_sort | Alessandra C Moraes |
| collection | DOAJ |
| description | Objective. Due to the importance of controlling ectoparasites, associated with the necessity of technical knowledge on the safety of topical treatment with organophosphates, pyrethroids and piperonyl butoxide to the animal organism, this bioassay was carried out to evaluate the clinical safety of the association of dichlorvos (45%) + cypermethrin (5%) + piperonyl butoxide (25%) administered by spray on the skin of cattle, through the study of clinical parameters, biochemical, haematological and behavioral changes. Materials and methods. Sixteen crossbred animals with a mean age of 18 months, males and females grouped into two treatments with eight animals each: T1 (1:800 v/v) and T2 (1:200 v/v). Were collected blood samples at six different times: before treatment (BT), 24, 48, 72, 96 and 192 hours post treatment (HPT). Results. The antiparasitic association administered by spray on the skin did not result in changes in the enzymatic activity of ALT, AST, GGT and ALP, as well as in serum albumin, triglycerides, cholesterol, urea and creatinine, demonstrating the safety of
this antiparasitic compound for maintaining hepatic and renal functionality. The erythrocyte, leukocyte and platelet studies showed no changes caused by treatments, and no clinical signs and behavioral changes were observed after treatment. Conclusions. These findings demonstrated good safety margin for spray treatment on the skin with this antiparasitic compound, even when administered at a dilution of 1:200 v/v, which is four times the dose recommended for ectoparasite control. |
| first_indexed | 2024-12-14T16:45:51Z |
| format | Article |
| id | doaj.art-6799a74b0a894e1d836e4501fd179f5d |
| institution | Directory Open Access Journal |
| issn | 0122-0268 1909-0544 |
| language | English |
| last_indexed | 2024-12-14T16:45:51Z |
| publishDate | 2015-11-01 |
| publisher | Universidad de Cordoba |
| record_format | Article |
| series | Revista MVZ Cordoba |
| spelling | doaj.art-6799a74b0a894e1d836e4501fd179f5d2022-12-21T22:54:12ZengUniversidad de CordobaRevista MVZ Cordoba0122-02681909-05442015-11-0120Suplemento48744883Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattleAlessandra C Moraes0 Ed JR Prado1Vanessa P Faria2Thais MS Gírio3Wilson G Manrique4Marco AA Belo5São Paulo State University – UNESP, Department of Preventive Veterinary Medicine, Via de acesso Prof. Paulo Donato Castellane s/n CEP 14884-900, Jaboticabal/SP - Brazil. São Paulo State University – UNESPDepartment of Veterinary Pathology, Via de acesso Prof. Paulo Donato Castellane s/n CEP 14884-900, Jaboticabal/SP - Brazil.São Paulo State University – UNESP, Department of Preventive Veterinary Medicine, Via de acesso Prof. Paulo Donato Castellane s/n CEP 14884-900, Jaboticabal/SP - Brazil. São Paulo State University – UNESPUzinas Chimicas Brasileiras S.A. Deparment of Research and Technical Development, Praça Dr. Joaquim Batista, 150, Centro 14870-090, Jaboticabal/SP – Brazil. Department of Veterinary Pathology, Via de acesso Prof. Paulo Donato Castellane s/n CEP 14884-900, Jaboticabal/SP - Brazil.São Paulo State University – UNESP, Department of Preventive Veterinary Medicine, Via de acesso Prof. Paulo Donato Castellane s/n CEP 14884-900, Jaboticabal/SP - Brazil. São Paulo State University – UNESPObjective. Due to the importance of controlling ectoparasites, associated with the necessity of technical knowledge on the safety of topical treatment with organophosphates, pyrethroids and piperonyl butoxide to the animal organism, this bioassay was carried out to evaluate the clinical safety of the association of dichlorvos (45%) + cypermethrin (5%) + piperonyl butoxide (25%) administered by spray on the skin of cattle, through the study of clinical parameters, biochemical, haematological and behavioral changes. Materials and methods. Sixteen crossbred animals with a mean age of 18 months, males and females grouped into two treatments with eight animals each: T1 (1:800 v/v) and T2 (1:200 v/v). Were collected blood samples at six different times: before treatment (BT), 24, 48, 72, 96 and 192 hours post treatment (HPT). Results. The antiparasitic association administered by spray on the skin did not result in changes in the enzymatic activity of ALT, AST, GGT and ALP, as well as in serum albumin, triglycerides, cholesterol, urea and creatinine, demonstrating the safety of this antiparasitic compound for maintaining hepatic and renal functionality. The erythrocyte, leukocyte and platelet studies showed no changes caused by treatments, and no clinical signs and behavioral changes were observed after treatment. Conclusions. These findings demonstrated good safety margin for spray treatment on the skin with this antiparasitic compound, even when administered at a dilution of 1:200 v/v, which is four times the dose recommended for ectoparasite control.http://revistas.unicordoba.edu.co/revistamvz/mvz-203s/pdf/v20Supl1a3.pdfClinical safetybovineorganophosphatespiperonyl butoxidepyrethroidsspray |
| spellingShingle | Alessandra C Moraes Ed JR Prado Vanessa P Faria Thais MS Gírio Wilson G Manrique Marco AA Belo Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattle Revista MVZ Cordoba Clinical safety bovine organophosphates piperonyl butoxide pyrethroids spray |
| title | Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattle |
| title_full | Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattle |
| title_fullStr | Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattle |
| title_full_unstemmed | Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattle |
| title_short | Clinical safety of dichlorvos (45%), cypermethrin (5%) and piperonyl butoxide (25%) administered by spray on the skin of cattle |
| title_sort | clinical safety of dichlorvos 45 cypermethrin 5 and piperonyl butoxide 25 administered by spray on the skin of cattle |
| topic | Clinical safety bovine organophosphates piperonyl butoxide pyrethroids spray |
| url | http://revistas.unicordoba.edu.co/revistamvz/mvz-203s/pdf/v20Supl1a3.pdf |
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