Impacts of Rapid Recanalization and Collateral Circulation on Clinical Outcome after Intraarterial Thrombolysis
Background and PurposeRapid recanalization might improve clinical outcomes after intraarterial thrombolysis (IAT) for acute ischemic stroke patients with collateral circulation. We determined whether rapid recanalization and collateral circulation affect clinical outcomes after IAT.MethodsWe retrosp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Stroke Society
2015-01-01
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| Series: | Journal of Stroke |
| Subjects: | |
| Online Access: | http://www.j-stroke.org/upload/pdf/jos-17-76.pdf |
| _version_ | 1818151112422719488 |
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| author | Hye Seon Jeong Hyon-Jo Kwon Hee-Jung Song Hyeon-Song Koh Yong Soo Kim Ju Hun Lee Jee Eun Shin Suk Hoon Lee Jei Kim |
| author_facet | Hye Seon Jeong Hyon-Jo Kwon Hee-Jung Song Hyeon-Song Koh Yong Soo Kim Ju Hun Lee Jee Eun Shin Suk Hoon Lee Jei Kim |
| author_sort | Hye Seon Jeong |
| collection | DOAJ |
| description | Background and PurposeRapid recanalization might improve clinical outcomes after intraarterial thrombolysis (IAT) for acute ischemic stroke patients with collateral circulation. We determined whether rapid recanalization and collateral circulation affect clinical outcomes after IAT.MethodsWe retrospectively evaluated the clinical and radiological data of 134 consecutive patients who underwent IAT for intracranial artery occlusion. The interval from symptom onset to recanalization after IAT (onset-to-recanalization time) as an estimate of the probability of good clinical outcome (modified Rankin scale 0-2) was calculated in patients with collateral circulation in the ischemic hemisphere, which was rated poor (0/1 American Society of Interventional and Therapeutic Neuroradiology criteria) or good (2-4). Changes in National Institute of Health Stroke Scale (NHISS) score before and after IAT and modified Rankins scale scores 3 months after discharge were compared with respect to onset-to-recanalization time.ResultsIn patients with good collateral circulation, the estimated onset-to-recanalization time for a 0.5 probability of a good clinical outcome was 347 minutes; with poor collateral circulation, it was 172 minutes for a 0.2 probability of good clinical outcome. Outcome analyses according to onset-to-recanalization time showed patients recanalized <6 hours had lower NHISS scores (<4.5, 4.5-6, >6 hours of onset-to-recanalization time, and non-recanalization: 5.1, 6.9, 11.9, and 19.8, respectively) at discharge and higher percentages of good clinical outcome (69%, 66.7%, 21.9%, and 0%, respectively) 3 months after IAT.ConclusionsThe time window to expect a high probability of a good clinical outcome after IAT is highly dependent on the collateral circulation. |
| first_indexed | 2024-12-11T13:33:39Z |
| format | Article |
| id | doaj.art-679a5f2347ba41f4b8936a18507cd00e |
| institution | Directory Open Access Journal |
| issn | 2287-6391 2287-6405 |
| language | English |
| last_indexed | 2024-12-11T13:33:39Z |
| publishDate | 2015-01-01 |
| publisher | Korean Stroke Society |
| record_format | Article |
| series | Journal of Stroke |
| spelling | doaj.art-679a5f2347ba41f4b8936a18507cd00e2022-12-22T01:05:08ZengKorean Stroke SocietyJournal of Stroke2287-63912287-64052015-01-01171768310.5853/jos.2015.17.1.7662Impacts of Rapid Recanalization and Collateral Circulation on Clinical Outcome after Intraarterial ThrombolysisHye Seon JeongHyon-Jo KwonHee-Jung SongHyeon-Song KohYong Soo KimJu Hun LeeJee Eun ShinSuk Hoon LeeJei KimBackground and PurposeRapid recanalization might improve clinical outcomes after intraarterial thrombolysis (IAT) for acute ischemic stroke patients with collateral circulation. We determined whether rapid recanalization and collateral circulation affect clinical outcomes after IAT.MethodsWe retrospectively evaluated the clinical and radiological data of 134 consecutive patients who underwent IAT for intracranial artery occlusion. The interval from symptom onset to recanalization after IAT (onset-to-recanalization time) as an estimate of the probability of good clinical outcome (modified Rankin scale 0-2) was calculated in patients with collateral circulation in the ischemic hemisphere, which was rated poor (0/1 American Society of Interventional and Therapeutic Neuroradiology criteria) or good (2-4). Changes in National Institute of Health Stroke Scale (NHISS) score before and after IAT and modified Rankins scale scores 3 months after discharge were compared with respect to onset-to-recanalization time.ResultsIn patients with good collateral circulation, the estimated onset-to-recanalization time for a 0.5 probability of a good clinical outcome was 347 minutes; with poor collateral circulation, it was 172 minutes for a 0.2 probability of good clinical outcome. Outcome analyses according to onset-to-recanalization time showed patients recanalized <6 hours had lower NHISS scores (<4.5, 4.5-6, >6 hours of onset-to-recanalization time, and non-recanalization: 5.1, 6.9, 11.9, and 19.8, respectively) at discharge and higher percentages of good clinical outcome (69%, 66.7%, 21.9%, and 0%, respectively) 3 months after IAT.ConclusionsThe time window to expect a high probability of a good clinical outcome after IAT is highly dependent on the collateral circulation.http://www.j-stroke.org/upload/pdf/jos-17-76.pdfischemic strokethrombolysiscollateral circulationrecanalizationclinical outcome |
| spellingShingle | Hye Seon Jeong Hyon-Jo Kwon Hee-Jung Song Hyeon-Song Koh Yong Soo Kim Ju Hun Lee Jee Eun Shin Suk Hoon Lee Jei Kim Impacts of Rapid Recanalization and Collateral Circulation on Clinical Outcome after Intraarterial Thrombolysis Journal of Stroke ischemic stroke thrombolysis collateral circulation recanalization clinical outcome |
| title | Impacts of Rapid Recanalization and Collateral Circulation on Clinical Outcome after Intraarterial Thrombolysis |
| title_full | Impacts of Rapid Recanalization and Collateral Circulation on Clinical Outcome after Intraarterial Thrombolysis |
| title_fullStr | Impacts of Rapid Recanalization and Collateral Circulation on Clinical Outcome after Intraarterial Thrombolysis |
| title_full_unstemmed | Impacts of Rapid Recanalization and Collateral Circulation on Clinical Outcome after Intraarterial Thrombolysis |
| title_short | Impacts of Rapid Recanalization and Collateral Circulation on Clinical Outcome after Intraarterial Thrombolysis |
| title_sort | impacts of rapid recanalization and collateral circulation on clinical outcome after intraarterial thrombolysis |
| topic | ischemic stroke thrombolysis collateral circulation recanalization clinical outcome |
| url | http://www.j-stroke.org/upload/pdf/jos-17-76.pdf |
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