Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infants
Abstract This study evaluated whether early pulmonary hypertension (PH) in extremely preterm infants (EPIs) at 22–27 weeks of gestation detected clinically with echocardiography at 4–7 postnatal days (PND) is a risk factor for death before 36 weeks post-menstrual age (PMA) or late PH in moderate or...
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| Format: | Article |
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Nature Portfolio
2021-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-90769-4 |
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| author | Hyun Ho Kim Se In Sung Mi Sun Yang Yea Seul Han Hye Seon Kim So Yoon Ahn Ga Won Jeon Yun Sil Chang Won Soon Park |
| author_facet | Hyun Ho Kim Se In Sung Mi Sun Yang Yea Seul Han Hye Seon Kim So Yoon Ahn Ga Won Jeon Yun Sil Chang Won Soon Park |
| author_sort | Hyun Ho Kim |
| collection | DOAJ |
| description | Abstract This study evaluated whether early pulmonary hypertension (PH) in extremely preterm infants (EPIs) at 22–27 weeks of gestation detected clinically with echocardiography at 4–7 postnatal days (PND) is a risk factor for death before 36 weeks post-menstrual age (PMA) or late PH in moderate or severe (m/s) bronchopulmonary dysplasia (BPD) (BPD-PH). We analyzed risk factors for death before 36 weeks PMA or BPD-PH. Among 247 EPIs enrolled, 74 (30.0%) had early PH. Twenty-one (28.4%) infants with early PH and 18 (10.4%) without early PH died before 36 weeks PMA; 14 (18.9%) infants with early PH and 9 (5.2%) without early PH had BPD-PH at 36–38 weeks PMA. Multivariate analysis revealed that early PH (adjusted odds ratio, 6.55; 95% confidence interval, 3.10–13.82, P < 0.05), clinical chorioamnionitis (2.50; 1.18–5.31), intraventricular hemorrhage (grade 3–4) (3.43; 1.26–9.37), and late sepsis (6.76; 3.20–14.28) independently increased the risk of development of death before 36 weeks PMA or BPD-PH. Subgroup analysis among m/s BPD patients revealed that early PH (4.50; 1.61–12.58) and prolonged invasive ventilator care (> 28 days) (4.91; 1.02–23.68) increased the risk for late PH independently. In conclusion, EPIs with early PH at 4–7 PND should be monitored for BPD-associated late PH development. |
| first_indexed | 2024-12-14T08:54:16Z |
| format | Article |
| id | doaj.art-679bc4997ef3423280c7c7ff072d0820 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T08:54:16Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-679bc4997ef3423280c7c7ff072d08202022-12-21T23:08:58ZengNature PortfolioScientific Reports2045-23222021-05-011111910.1038/s41598-021-90769-4Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infantsHyun Ho Kim0Se In Sung1Mi Sun Yang2Yea Seul Han3Hye Seon Kim4So Yoon Ahn5Ga Won Jeon6Yun Sil Chang7Won Soon Park8Research Institute of Clinical Medicine of Jeonbuk National UniversityDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pediatrics, Hallym University Kangnam Sacred Heart HospitalDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pediatrics, Busan Paik Hospital, Inje University College of MedicineDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract This study evaluated whether early pulmonary hypertension (PH) in extremely preterm infants (EPIs) at 22–27 weeks of gestation detected clinically with echocardiography at 4–7 postnatal days (PND) is a risk factor for death before 36 weeks post-menstrual age (PMA) or late PH in moderate or severe (m/s) bronchopulmonary dysplasia (BPD) (BPD-PH). We analyzed risk factors for death before 36 weeks PMA or BPD-PH. Among 247 EPIs enrolled, 74 (30.0%) had early PH. Twenty-one (28.4%) infants with early PH and 18 (10.4%) without early PH died before 36 weeks PMA; 14 (18.9%) infants with early PH and 9 (5.2%) without early PH had BPD-PH at 36–38 weeks PMA. Multivariate analysis revealed that early PH (adjusted odds ratio, 6.55; 95% confidence interval, 3.10–13.82, P < 0.05), clinical chorioamnionitis (2.50; 1.18–5.31), intraventricular hemorrhage (grade 3–4) (3.43; 1.26–9.37), and late sepsis (6.76; 3.20–14.28) independently increased the risk of development of death before 36 weeks PMA or BPD-PH. Subgroup analysis among m/s BPD patients revealed that early PH (4.50; 1.61–12.58) and prolonged invasive ventilator care (> 28 days) (4.91; 1.02–23.68) increased the risk for late PH independently. In conclusion, EPIs with early PH at 4–7 PND should be monitored for BPD-associated late PH development.https://doi.org/10.1038/s41598-021-90769-4 |
| spellingShingle | Hyun Ho Kim Se In Sung Mi Sun Yang Yea Seul Han Hye Seon Kim So Yoon Ahn Ga Won Jeon Yun Sil Chang Won Soon Park Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infants Scientific Reports |
| title | Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infants |
| title_full | Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infants |
| title_fullStr | Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infants |
| title_full_unstemmed | Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infants |
| title_short | Early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia-associated late pulmonary hypertension in extremely preterm infants |
| title_sort | early pulmonary hypertension is a risk factor for bronchopulmonary dysplasia associated late pulmonary hypertension in extremely preterm infants |
| url | https://doi.org/10.1038/s41598-021-90769-4 |
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