Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies
Diabetes mellitus, a major cause of mortality around the globe, can result in several secondary complications, including diabetic foot syndrome, which is brought on by diabetic neuropathy and ischemia. Approximately 15% of diabetic patients suffer from diabetic foot complications, and among them 25%...
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MDPI AG
2022-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/22/11777 |
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| author | Prawej Ansari Samia Akther Joyeeta T. Khan Sara S. Islam Md. Samim R. Masud Anisur Rahman Veronique Seidel Yasser H. A. Abdel-Wahab |
| author_facet | Prawej Ansari Samia Akther Joyeeta T. Khan Sara S. Islam Md. Samim R. Masud Anisur Rahman Veronique Seidel Yasser H. A. Abdel-Wahab |
| author_sort | Prawej Ansari |
| collection | DOAJ |
| description | Diabetes mellitus, a major cause of mortality around the globe, can result in several secondary complications, including diabetic foot syndrome, which is brought on by diabetic neuropathy and ischemia. Approximately 15% of diabetic patients suffer from diabetic foot complications, and among them 25% are at risk of lower limb amputations. Diabetic foot ulcers are characterized as skin lesions, gangrene, or necrosis, and may develop due to several reasons, including hyperglycemia and slower wound healing in diabetic patients. A management protocol involving wound cleaning, oral antibiotics, skin ointments, and removing dead tissue is currently followed to treat diabetic foot ulcers. In severe cases, amputation is performed to prevent the infection from spreading further. The existing therapy can be costly and present adverse side effects. Combined with a lack of vascular surgeons, this ultimately results in disability, especially in developing nations. There is a growing interest in the use of alternative therapies, such as medicinal plants, to discover more efficient and affordable treatments for diabetic foot syndrome. It has been observed that treatment with numerous plants, including <i>Carica papaya</i>, <i>Annona squamosa</i>, <i>Catharanthus roseus</i>, and <i>Centella asiatica</i>, promotes wound healing, reduces inflammation, and may decrease the number of amputations. However, little information is currently available on the prevention and management of diabetic foot ulcers, and additional research is necessary to completely understand the role of alternative therapies in the treatment of diabetic foot complications. |
| first_indexed | 2024-03-09T18:29:20Z |
| format | Article |
| id | doaj.art-679cf6bc721a4ee4977f412abc9f3cd1 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T18:29:20Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-679cf6bc721a4ee4977f412abc9f3cd12023-11-24T07:40:46ZengMDPI AGApplied Sciences2076-34172022-11-0112221177710.3390/app122211777Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative TherapiesPrawej Ansari0Samia Akther1Joyeeta T. Khan2Sara S. Islam3Md. Samim R. Masud4Anisur Rahman5Veronique Seidel6Yasser H. A. Abdel-Wahab7Department of Pharmacy, School of Pharmacy and Public Health, Independent University, Bangladesh (IUB), Dhaka 1229, BangladeshDepartment of Pharmacy, School of Pharmacy and Public Health, Independent University, Bangladesh (IUB), Dhaka 1229, BangladeshDepartment of Pharmacy, School of Pharmacy and Public Health, Independent University, Bangladesh (IUB), Dhaka 1229, BangladeshDepartment of Pharmacy, School of Pharmacy and Public Health, Independent University, Bangladesh (IUB), Dhaka 1229, BangladeshDepartment of Pharmacy, School of Pharmacy and Public Health, Independent University, Bangladesh (IUB), Dhaka 1229, BangladeshDepartment of Pharmacy, School of Pharmacy and Public Health, Independent University, Bangladesh (IUB), Dhaka 1229, BangladeshNatural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UKSchool of Biomedical Sciences, Ulster University, Coleraine BT52 1SA, UKDiabetes mellitus, a major cause of mortality around the globe, can result in several secondary complications, including diabetic foot syndrome, which is brought on by diabetic neuropathy and ischemia. Approximately 15% of diabetic patients suffer from diabetic foot complications, and among them 25% are at risk of lower limb amputations. Diabetic foot ulcers are characterized as skin lesions, gangrene, or necrosis, and may develop due to several reasons, including hyperglycemia and slower wound healing in diabetic patients. A management protocol involving wound cleaning, oral antibiotics, skin ointments, and removing dead tissue is currently followed to treat diabetic foot ulcers. In severe cases, amputation is performed to prevent the infection from spreading further. The existing therapy can be costly and present adverse side effects. Combined with a lack of vascular surgeons, this ultimately results in disability, especially in developing nations. There is a growing interest in the use of alternative therapies, such as medicinal plants, to discover more efficient and affordable treatments for diabetic foot syndrome. It has been observed that treatment with numerous plants, including <i>Carica papaya</i>, <i>Annona squamosa</i>, <i>Catharanthus roseus</i>, and <i>Centella asiatica</i>, promotes wound healing, reduces inflammation, and may decrease the number of amputations. However, little information is currently available on the prevention and management of diabetic foot ulcers, and additional research is necessary to completely understand the role of alternative therapies in the treatment of diabetic foot complications.https://www.mdpi.com/2076-3417/12/22/11777hyperglycemiadiabetic footinfectionglucosealternative medicine |
| spellingShingle | Prawej Ansari Samia Akther Joyeeta T. Khan Sara S. Islam Md. Samim R. Masud Anisur Rahman Veronique Seidel Yasser H. A. Abdel-Wahab Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies Applied Sciences hyperglycemia diabetic foot infection glucose alternative medicine |
| title | Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies |
| title_full | Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies |
| title_fullStr | Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies |
| title_full_unstemmed | Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies |
| title_short | Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies |
| title_sort | hyperglycaemia linked diabetic foot complications and their management using conventional and alternative therapies |
| topic | hyperglycemia diabetic foot infection glucose alternative medicine |
| url | https://www.mdpi.com/2076-3417/12/22/11777 |
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