Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid
The histopathologic view of keloid shows dense fibroblasts and bundles of collagen throughout dermis. Treatment that completely cure keloid still not exist, although there are many treatment options. The monotherapy fractional CO2 laser shows good results, but is still as an adjuvant therapy. Fracti...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2019-03-01
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| Series: | Dermatology Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/8032 |
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| author | M. Yulianto Listiawan Dwi Murtiastutik Willy Sandhika Brama Rachmantyo Putri Hendria Wardhani |
| author_facet | M. Yulianto Listiawan Dwi Murtiastutik Willy Sandhika Brama Rachmantyo Putri Hendria Wardhani |
| author_sort | M. Yulianto Listiawan |
| collection | DOAJ |
| description | The histopathologic view of keloid shows dense fibroblasts and bundles of collagen throughout dermis. Treatment that completely cure keloid still not exist, although there are many treatment options. The monotherapy fractional CO2 laser shows good results, but is still as an adjuvant therapy. Fractional CO2 laser affects fibroblast and its functions in producing collagen. The combination therapy will combine the selective phototermolysis effect of CO2 lasers with antimitotic and antiinflammatory effects of corticosteroids. This study was an open trial with parallel design that compared fractional CO2 laser-intralesional triamcinolone acetonide combination therapy (treatment group) and intralesional triamcinolone acetonide (control group) in keloid patients with collagen density as evaluation parameter. The dose of triamcinolone was 10 mg/ml of 0.05-0.1 ml/cm2 of keloid. Fractional CO2 laser energy setting was 10-20 mJ. The decrease of collagen density in control and treatment group was significant (p=0.008 and p=0.001), although the decrease difference between control and treatment group was not significant (p=0.328). The collagen density that decrease in a shorter time shows that fractional CO2 laser could be a good combination therapy. |
| first_indexed | 2024-12-11T03:02:59Z |
| format | Article |
| id | doaj.art-679d8aa1a2764398845bc94569213904 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-12-11T03:02:59Z |
| publishDate | 2019-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-679d8aa1a2764398845bc945692139042022-12-22T01:23:00ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062019-03-01111s10.4081/dr.2019.8032Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloidM. Yulianto Listiawan0Dwi Murtiastutik1Willy Sandhika2Brama Rachmantyo3Putri Hendria Wardhani4Department of Dermatology and Venereology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, SurabayaDepartment of Dermatology and Venereology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, SurabayaDepartment of Anatomic Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, SurabayaDepartment of Dermatology and Venereology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, SurabayaDepartment of Dermatology and Venereology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Hospital, SurabayaThe histopathologic view of keloid shows dense fibroblasts and bundles of collagen throughout dermis. Treatment that completely cure keloid still not exist, although there are many treatment options. The monotherapy fractional CO2 laser shows good results, but is still as an adjuvant therapy. Fractional CO2 laser affects fibroblast and its functions in producing collagen. The combination therapy will combine the selective phototermolysis effect of CO2 lasers with antimitotic and antiinflammatory effects of corticosteroids. This study was an open trial with parallel design that compared fractional CO2 laser-intralesional triamcinolone acetonide combination therapy (treatment group) and intralesional triamcinolone acetonide (control group) in keloid patients with collagen density as evaluation parameter. The dose of triamcinolone was 10 mg/ml of 0.05-0.1 ml/cm2 of keloid. Fractional CO2 laser energy setting was 10-20 mJ. The decrease of collagen density in control and treatment group was significant (p=0.008 and p=0.001), although the decrease difference between control and treatment group was not significant (p=0.328). The collagen density that decrease in a shorter time shows that fractional CO2 laser could be a good combination therapy.https://www.pagepress.org/journals/index.php/dr/article/view/8032CO2keloidlasertherapytriamcinolone |
| spellingShingle | M. Yulianto Listiawan Dwi Murtiastutik Willy Sandhika Brama Rachmantyo Putri Hendria Wardhani Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid Dermatology Reports CO2 keloid laser therapy triamcinolone |
| title | Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid |
| title_full | Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid |
| title_fullStr | Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid |
| title_full_unstemmed | Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid |
| title_short | Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid |
| title_sort | comparison between fractional co2 laser triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid |
| topic | CO2 keloid laser therapy triamcinolone |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/8032 |
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