Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
Objectives: In thoracic aortic aneurysm (TAA) of the ascending aorta (AA), AA is progressively dilating due to the weakening of the aortic wall. Predicting and preventing aortic dissections and ruptures in TAA continues to be challenging, and more accurate assessment of the AA dilatation, identifica...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.934941/full |
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| author | Miika Kiema Jaakko K. Sarin Jaakko K. Sarin Jaakko K. Sarin S. Petteri Kauhanen Jari Torniainen Hanna Matikka Emma-Sofia Luoto Pekka Jaakkola Petri Saari Timo Liimatainen Timo Liimatainen Ritva Vanninen Seppo Ylä-Herttuala Seppo Ylä-Herttuala Seppo Ylä-Herttuala Marja Hedman Marja Hedman Marja Hedman Johanna P. Laakkonen |
| author_facet | Miika Kiema Jaakko K. Sarin Jaakko K. Sarin Jaakko K. Sarin S. Petteri Kauhanen Jari Torniainen Hanna Matikka Emma-Sofia Luoto Pekka Jaakkola Petri Saari Timo Liimatainen Timo Liimatainen Ritva Vanninen Seppo Ylä-Herttuala Seppo Ylä-Herttuala Seppo Ylä-Herttuala Marja Hedman Marja Hedman Marja Hedman Johanna P. Laakkonen |
| author_sort | Miika Kiema |
| collection | DOAJ |
| description | Objectives: In thoracic aortic aneurysm (TAA) of the ascending aorta (AA), AA is progressively dilating due to the weakening of the aortic wall. Predicting and preventing aortic dissections and ruptures in TAA continues to be challenging, and more accurate assessment of the AA dilatation, identification of high-risk patients, and timing of repair surgery are required. We investigated whether wall shear stress (WSS) predicts pathological and biomechanical changes in the aortic wall in TAA.Methods: The study included 12 patients with bicuspid (BAV) and 20 patients with the tricuspid aortic valve (TAV). 4D flow magnetic resonance imaging (MRI) was performed a day before aortic replacement surgery. Biomechanical and histological parameters, including assessing of wall strength, media degeneration, elastin, and cell content were analyzed from the resected AA samples.Results: WSSs were greater in the outer curves of the AA compared to the inner curves in all TAA patients. WSSs correlated with media degeneration of the aortic wall (ρ = -0.48, p < 0.01), elastin content (ρ = 0.47, p < 0.01), and aortic wall strength (ρ = -0.49, p = 0.029). Subsequently, the media of the outer curves was thinner, more rigid, and tolerated lower failure strains. Failure values were shown to correlate with smooth muscle cell (SMC) density (ρ = -0.45, p < 0.02), and indicated the more MYH10+ SMCs the lower the strength of the aortic wall structure. More macrophages were detected in patients with severe media degeneration and the areas with lower WSSs.Conclusion: The findings indicate that MRI-derived WSS predicts pathological and biomechanical changes in the aortic wall in patients with TAA and could be used for identification of high-risk patients. |
| first_indexed | 2024-04-13T21:24:06Z |
| format | Article |
| id | doaj.art-67a2d2a3fb9e4a65adf1b54ea2b12844 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T21:24:06Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-67a2d2a3fb9e4a65adf1b54ea2b128442022-12-22T02:29:23ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-07-011310.3389/fphys.2022.934941934941Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic AortaMiika Kiema0Jaakko K. Sarin1Jaakko K. Sarin2Jaakko K. Sarin3S. Petteri Kauhanen4Jari Torniainen5Hanna Matikka6Emma-Sofia Luoto7Pekka Jaakkola8Petri Saari9Timo Liimatainen10Timo Liimatainen11Ritva Vanninen12Seppo Ylä-Herttuala13Seppo Ylä-Herttuala14Seppo Ylä-Herttuala15Marja Hedman16Marja Hedman17Marja Hedman18Johanna P. Laakkonen19A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandDepartment of Clinical Radiology, Kuopio University Hospital, Kuopio, FinlandDepartment of Applied Physics, University of Eastern Finland, Kuopio, FinlandDepartment of Medical Physics, Medical Imaging Center, Pirkanmaa Hospital District, Tampere, FinlandDepartment of Clinical Radiology, Kuopio University Hospital, Kuopio, FinlandDepartment of Applied Physics, University of Eastern Finland, Kuopio, FinlandDepartment of Clinical Radiology, Kuopio University Hospital, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandDepartment of Heart and Thoracic Surgery, Kuopio University Hospital, Heart Center, Kuopio, FinlandDepartment of Clinical Radiology, Kuopio University Hospital, Kuopio, FinlandDepartment of Clinical Radiology, Kuopio University Hospital, Kuopio, FinlandResearch Unit of Medical Imaging, Physics and Technology, Oulu University Hospital, Oulu, FinlandDepartment of Clinical Radiology, Kuopio University Hospital, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandScience Service Center, Kuopio University Hospital, Kuopio, FinlandGene Therapy Unit, Kuopio University Hospital, Kuopio, FinlandDepartment of Clinical Radiology, Kuopio University Hospital, Kuopio, FinlandDepartment of Heart and Thoracic Surgery, Kuopio University Hospital, Heart Center, Kuopio, FinlandInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandObjectives: In thoracic aortic aneurysm (TAA) of the ascending aorta (AA), AA is progressively dilating due to the weakening of the aortic wall. Predicting and preventing aortic dissections and ruptures in TAA continues to be challenging, and more accurate assessment of the AA dilatation, identification of high-risk patients, and timing of repair surgery are required. We investigated whether wall shear stress (WSS) predicts pathological and biomechanical changes in the aortic wall in TAA.Methods: The study included 12 patients with bicuspid (BAV) and 20 patients with the tricuspid aortic valve (TAV). 4D flow magnetic resonance imaging (MRI) was performed a day before aortic replacement surgery. Biomechanical and histological parameters, including assessing of wall strength, media degeneration, elastin, and cell content were analyzed from the resected AA samples.Results: WSSs were greater in the outer curves of the AA compared to the inner curves in all TAA patients. WSSs correlated with media degeneration of the aortic wall (ρ = -0.48, p < 0.01), elastin content (ρ = 0.47, p < 0.01), and aortic wall strength (ρ = -0.49, p = 0.029). Subsequently, the media of the outer curves was thinner, more rigid, and tolerated lower failure strains. Failure values were shown to correlate with smooth muscle cell (SMC) density (ρ = -0.45, p < 0.02), and indicated the more MYH10+ SMCs the lower the strength of the aortic wall structure. More macrophages were detected in patients with severe media degeneration and the areas with lower WSSs.Conclusion: The findings indicate that MRI-derived WSS predicts pathological and biomechanical changes in the aortic wall in patients with TAA and could be used for identification of high-risk patients.https://www.frontiersin.org/articles/10.3389/fphys.2022.934941/fullthoracic aortic aneurysm (TAA)wall shear stressmedia degenerationsmooth muscle cellswall strength4D flow MRI |
| spellingShingle | Miika Kiema Jaakko K. Sarin Jaakko K. Sarin Jaakko K. Sarin S. Petteri Kauhanen Jari Torniainen Hanna Matikka Emma-Sofia Luoto Pekka Jaakkola Petri Saari Timo Liimatainen Timo Liimatainen Ritva Vanninen Seppo Ylä-Herttuala Seppo Ylä-Herttuala Seppo Ylä-Herttuala Marja Hedman Marja Hedman Marja Hedman Johanna P. Laakkonen Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta Frontiers in Physiology thoracic aortic aneurysm (TAA) wall shear stress media degeneration smooth muscle cells wall strength 4D flow MRI |
| title | Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta |
| title_full | Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta |
| title_fullStr | Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta |
| title_full_unstemmed | Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta |
| title_short | Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta |
| title_sort | wall shear stress predicts media degeneration and biomechanical changes in thoracic aorta |
| topic | thoracic aortic aneurysm (TAA) wall shear stress media degeneration smooth muscle cells wall strength 4D flow MRI |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.934941/full |
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