Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice
Because diminished pulmonary function in chronic obstructive pulmonary disease (COPD) is not fully reversible, it is important to prevent and manage COPD through smoking cessation, reducing exposure to air pollutants, and a healthy diet with functional foods. Thus, to confirm the availability of Lac...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624000458 |
| _version_ | 1797311582985781248 |
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| author | Gun-Dong Kim Ji-Eun Eom Young In Kim Dong-Uk Shin Kyung Min Lim Hyeon-Ji Song Eun Yeong Lim Ju Hye Song Ha-Jung Kim Byeong Yeob Jeon Kyung Hwa Song Hee Soon Shin So-Young Lee |
| author_facet | Gun-Dong Kim Ji-Eun Eom Young In Kim Dong-Uk Shin Kyung Min Lim Hyeon-Ji Song Eun Yeong Lim Ju Hye Song Ha-Jung Kim Byeong Yeob Jeon Kyung Hwa Song Hee Soon Shin So-Young Lee |
| author_sort | Gun-Dong Kim |
| collection | DOAJ |
| description | Because diminished pulmonary function in chronic obstructive pulmonary disease (COPD) is not fully reversible, it is important to prevent and manage COPD through smoking cessation, reducing exposure to air pollutants, and a healthy diet with functional foods. Thus, to confirm the availability of Lactiplantibacillus plantarum KF511 as a functional food for lung health, we evaluated the alleviating effect of L. plantarum KF511 on lung injuries in a cigarette smoke extract and elastase-induced COPD mouse and phorbol 12-myristate 13-acetate-stimulated NCI-H292 cells. L. plantarum KF511 suppressed the immune cell infiltration and production of mucin, matrix metalloproteinases, cytokines, and chemokines in bronchoalveolar lavage fluid, and alleviated tissue damage and mucin hypersecretion in the lungs. In addition, L. plantarum KF511 inhibited the activation of mitogen-activated protein kinases in the lungs of COPD mice and NCI-H292 cells. These results suggest that L. plantarum KF511 is an effective probiotic supplement to prevent and manage respiratory diseases. |
| first_indexed | 2024-03-08T02:02:10Z |
| format | Article |
| id | doaj.art-67a3c3d6fbbb4dd99bb1fea8646f2c01 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T02:02:10Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-67a3c3d6fbbb4dd99bb1fea8646f2c012024-02-14T05:14:37ZengElsevierJournal of Functional Foods1756-46462024-02-01113106043Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in miceGun-Dong Kim0Ji-Eun Eom1Young In Kim2Dong-Uk Shin3Kyung Min Lim4Hyeon-Ji Song5Eun Yeong Lim6Ju Hye Song7Ha-Jung Kim8Byeong Yeob Jeon9Kyung Hwa Song10Hee Soon Shin11So-Young Lee12Divison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of KoreaQBM Co.Ltd. Seoul-Si, Republic of KoreaQBM Co.Ltd. Seoul-Si, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Republic of KoreaDivison of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Republic of Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Republic of Korea; Corresponding author at: Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea.Because diminished pulmonary function in chronic obstructive pulmonary disease (COPD) is not fully reversible, it is important to prevent and manage COPD through smoking cessation, reducing exposure to air pollutants, and a healthy diet with functional foods. Thus, to confirm the availability of Lactiplantibacillus plantarum KF511 as a functional food for lung health, we evaluated the alleviating effect of L. plantarum KF511 on lung injuries in a cigarette smoke extract and elastase-induced COPD mouse and phorbol 12-myristate 13-acetate-stimulated NCI-H292 cells. L. plantarum KF511 suppressed the immune cell infiltration and production of mucin, matrix metalloproteinases, cytokines, and chemokines in bronchoalveolar lavage fluid, and alleviated tissue damage and mucin hypersecretion in the lungs. In addition, L. plantarum KF511 inhibited the activation of mitogen-activated protein kinases in the lungs of COPD mice and NCI-H292 cells. These results suggest that L. plantarum KF511 is an effective probiotic supplement to prevent and manage respiratory diseases.http://www.sciencedirect.com/science/article/pii/S1756464624000458Lactiplantibacillus plantarumProbioticsLung inflammationMucin hypersecretionCOPDMAPKs |
| spellingShingle | Gun-Dong Kim Ji-Eun Eom Young In Kim Dong-Uk Shin Kyung Min Lim Hyeon-Ji Song Eun Yeong Lim Ju Hye Song Ha-Jung Kim Byeong Yeob Jeon Kyung Hwa Song Hee Soon Shin So-Young Lee Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice Journal of Functional Foods Lactiplantibacillus plantarum Probiotics Lung inflammation Mucin hypersecretion COPD MAPKs |
| title | Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice |
| title_full | Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice |
| title_fullStr | Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice |
| title_full_unstemmed | Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice |
| title_short | Lactiplantibacillus plantarum KF511 ameliorates cigarette smoke extract and porcine pancreatic elastase-induced COPD via inhibition of MAPKs in mice |
| title_sort | lactiplantibacillus plantarum kf511 ameliorates cigarette smoke extract and porcine pancreatic elastase induced copd via inhibition of mapks in mice |
| topic | Lactiplantibacillus plantarum Probiotics Lung inflammation Mucin hypersecretion COPD MAPKs |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000458 |
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