Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms
Background: Obstructive sleep apnea (OSA) is one of the major co-morbidities and aggravating factors of asthma. In OSA-complicated asthma, obesity, visceral fat, and systemic inflammation are associated with its severity, but the role of bronchial hyperresponsiveness (BHR) is unclear. We investigate...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893023001107 |
| _version_ | 1797238043458928640 |
|---|---|
| author | Akiko Sano Takenori Kozuka Nanase Watatani Yuuki Kunita Yoshiyuki Kawabata Kyuya Gose Ken Shirahase Kazuya Yoshikawa Ryo Yamazaki Yusaku Nishikawa Takashi Omori Osamu Nishiyama Takashi Iwanaga Hiroyuki Sano Ryuta Haraguchi Yuji Tohda Hisako Matsumoto |
| author_facet | Akiko Sano Takenori Kozuka Nanase Watatani Yuuki Kunita Yoshiyuki Kawabata Kyuya Gose Ken Shirahase Kazuya Yoshikawa Ryo Yamazaki Yusaku Nishikawa Takashi Omori Osamu Nishiyama Takashi Iwanaga Hiroyuki Sano Ryuta Haraguchi Yuji Tohda Hisako Matsumoto |
| author_sort | Akiko Sano |
| collection | DOAJ |
| description | Background: Obstructive sleep apnea (OSA) is one of the major co-morbidities and aggravating factors of asthma. In OSA-complicated asthma, obesity, visceral fat, and systemic inflammation are associated with its severity, but the role of bronchial hyperresponsiveness (BHR) is unclear. We investigated the involvement of BHR and mediastinal fat width, as a measure of visceral fat, with OSA severity in patients with OSA and asthma-like symptoms. Methods: Patients with OSA who underwent BHR test and chest computed tomography scan for asthma-like symptoms were retrospectively enrolled. We evaluated the relationship between apnea–hypopnea index (AHI) and PC20 or anterior mediastinal fat width, stratified by the presence or absence of BHR. Results: OSA patients with BHR (n = 29) showed more obstructive airways and frequent low arousal threshold and lower mediastinal fat width, and tended to show fewer AHI than those without BHR (n = 25). In the overall analysis, mediastinal fat width was significantly positively correlated with AHI, which was significant even after adjustment with age and gender. This was especially significant in patients without BHR, while in OSA patients with BHR, there were significant negative associations between apnea index and airflow limitation, and hypopnea index and PC20. Conclusions: Risk factors for greater AHI differed depending on the presence or absence of BHR in OSA patients with asthma-like symptoms. In the presence of BHR, severity of asthma may determine the severity of concomitant OSA. |
| first_indexed | 2024-04-24T17:29:22Z |
| format | Article |
| id | doaj.art-67a4fe33267247b68a1eede4e9ee62d1 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-24T17:29:22Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-67a4fe33267247b68a1eede4e9ee62d12024-03-28T06:37:15ZengElsevierAllergology International1323-89302024-04-01732231235Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptomsAkiko Sano0Takenori Kozuka1Nanase Watatani2Yuuki Kunita3Yoshiyuki Kawabata4Kyuya Gose5Ken Shirahase6Kazuya Yoshikawa7Ryo Yamazaki8Yusaku Nishikawa9Takashi Omori10Osamu Nishiyama11Takashi Iwanaga12Hiroyuki Sano13Ryuta Haraguchi14Yuji Tohda15Hisako Matsumoto16Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Radiology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanCenter for General Medical Education and Clinical Training, Kindai University Hospital, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, JapanKindai University Hospital, Osaka, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan; Corresponding author. Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka 589-0014, Japan.Background: Obstructive sleep apnea (OSA) is one of the major co-morbidities and aggravating factors of asthma. In OSA-complicated asthma, obesity, visceral fat, and systemic inflammation are associated with its severity, but the role of bronchial hyperresponsiveness (BHR) is unclear. We investigated the involvement of BHR and mediastinal fat width, as a measure of visceral fat, with OSA severity in patients with OSA and asthma-like symptoms. Methods: Patients with OSA who underwent BHR test and chest computed tomography scan for asthma-like symptoms were retrospectively enrolled. We evaluated the relationship between apnea–hypopnea index (AHI) and PC20 or anterior mediastinal fat width, stratified by the presence or absence of BHR. Results: OSA patients with BHR (n = 29) showed more obstructive airways and frequent low arousal threshold and lower mediastinal fat width, and tended to show fewer AHI than those without BHR (n = 25). In the overall analysis, mediastinal fat width was significantly positively correlated with AHI, which was significant even after adjustment with age and gender. This was especially significant in patients without BHR, while in OSA patients with BHR, there were significant negative associations between apnea index and airflow limitation, and hypopnea index and PC20. Conclusions: Risk factors for greater AHI differed depending on the presence or absence of BHR in OSA patients with asthma-like symptoms. In the presence of BHR, severity of asthma may determine the severity of concomitant OSA.http://www.sciencedirect.com/science/article/pii/S1323893023001107Airway hyperresponsivenessAsthma-like symptomsHypopneaMediastinal fat widthObstructive sleep apnea |
| spellingShingle | Akiko Sano Takenori Kozuka Nanase Watatani Yuuki Kunita Yoshiyuki Kawabata Kyuya Gose Ken Shirahase Kazuya Yoshikawa Ryo Yamazaki Yusaku Nishikawa Takashi Omori Osamu Nishiyama Takashi Iwanaga Hiroyuki Sano Ryuta Haraguchi Yuji Tohda Hisako Matsumoto Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms Allergology International Airway hyperresponsiveness Asthma-like symptoms Hypopnea Mediastinal fat width Obstructive sleep apnea |
| title | Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms |
| title_full | Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms |
| title_fullStr | Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms |
| title_full_unstemmed | Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms |
| title_short | Role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma-like symptoms |
| title_sort | role of bronchial hyperresponsiveness in patients with obstructive sleep apnea with asthma like symptoms |
| topic | Airway hyperresponsiveness Asthma-like symptoms Hypopnea Mediastinal fat width Obstructive sleep apnea |
| url | http://www.sciencedirect.com/science/article/pii/S1323893023001107 |
| work_keys_str_mv | AT akikosano roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT takenorikozuka roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT nanasewatatani roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT yuukikunita roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT yoshiyukikawabata roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT kyuyagose roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT kenshirahase roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT kazuyayoshikawa roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT ryoyamazaki roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT yusakunishikawa roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT takashiomori roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT osamunishiyama roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT takashiiwanaga roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT hiroyukisano roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT ryutaharaguchi roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT yujitohda roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms AT hisakomatsumoto roleofbronchialhyperresponsivenessinpatientswithobstructivesleepapneawithasthmalikesymptoms |