Nano-Drug Delivery Systems Based on Natural Products
Ying Lv, Wenqing Li, Wei Liao, Haibo Jiang, Yuwei Liu, Jiansheng Cao, Wenfei Lu, Yufei Feng Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040, People’s Republic of ChinaCorrespondence: Yufei Feng, 150040, T...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-01-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/nano-drug-delivery-systems-based-on-natural-products-peer-reviewed-fulltext-article-IJN |
| _version_ | 1797351831567859712 |
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| author | Lv Y Li W Liao W Jiang H Liu Y Cao J Lu W Feng Y |
| author_facet | Lv Y Li W Liao W Jiang H Liu Y Cao J Lu W Feng Y |
| author_sort | Lv Y |
| collection | DOAJ |
| description | Ying Lv, Wenqing Li, Wei Liao, Haibo Jiang, Yuwei Liu, Jiansheng Cao, Wenfei Lu, Yufei Feng Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040, People’s Republic of ChinaCorrespondence: Yufei Feng, 150040, Tel +86-18503653988, Email fuf-002@163.comAbstract: Natural products have proven to have significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, and treatment. Compared with synthetic drugs, natural products not only have diverse structures but also exhibit a range of biological activities against different disease states and molecular targets, making them attractive for development in the field of medicine. Despite advancements in the use of natural products for clinical purposes, there remain obstacles that hinder their full potential. These challenges include issues such as limited solubility and stability when administered orally, as well as short durations of effectiveness. To address these concerns, nano-drug delivery systems have emerged as a promising solution to overcome the barriers faced in the clinical application of natural products. These systems offer notable advantages, such as a large specific surface area, enhanced targeting capabilities, and the ability to achieve sustained and controlled release. Extensive in vitro and in vivo studies have provided further evidence supporting the efficacy and safety of nanoparticle-based systems in delivering natural products in preclinical disease models. This review describes the limitations of natural product applications and the current status of natural products combined with nanotechnology. The latest advances in nano-drug delivery systems for delivery of natural products are considered from three aspects: connecting targeting warheads, self-assembly, and co-delivery. Finally, the challenges faced in the clinical translation of nano-drugs are discussed. Keywords: natural products, nanotechnology, drug delivery, targeting |
| first_indexed | 2024-03-08T13:06:10Z |
| format | Article |
| id | doaj.art-67a875acb1d043ed8543417d52ce8f0f |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-08T13:06:10Z |
| publishDate | 2024-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-67a875acb1d043ed8543417d52ce8f0f2024-01-18T18:05:05ZengDove Medical PressInternational Journal of Nanomedicine1178-20132024-01-01Volume 1954156989798Nano-Drug Delivery Systems Based on Natural ProductsLv YLi WLiao WJiang HLiu YCao JLu WFeng YYing Lv, Wenqing Li, Wei Liao, Haibo Jiang, Yuwei Liu, Jiansheng Cao, Wenfei Lu, Yufei Feng Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040, People’s Republic of ChinaCorrespondence: Yufei Feng, 150040, Tel +86-18503653988, Email fuf-002@163.comAbstract: Natural products have proven to have significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, and treatment. Compared with synthetic drugs, natural products not only have diverse structures but also exhibit a range of biological activities against different disease states and molecular targets, making them attractive for development in the field of medicine. Despite advancements in the use of natural products for clinical purposes, there remain obstacles that hinder their full potential. These challenges include issues such as limited solubility and stability when administered orally, as well as short durations of effectiveness. To address these concerns, nano-drug delivery systems have emerged as a promising solution to overcome the barriers faced in the clinical application of natural products. These systems offer notable advantages, such as a large specific surface area, enhanced targeting capabilities, and the ability to achieve sustained and controlled release. Extensive in vitro and in vivo studies have provided further evidence supporting the efficacy and safety of nanoparticle-based systems in delivering natural products in preclinical disease models. This review describes the limitations of natural product applications and the current status of natural products combined with nanotechnology. The latest advances in nano-drug delivery systems for delivery of natural products are considered from three aspects: connecting targeting warheads, self-assembly, and co-delivery. Finally, the challenges faced in the clinical translation of nano-drugs are discussed. Keywords: natural products, nanotechnology, drug delivery, targetinghttps://www.dovepress.com/nano-drug-delivery-systems-based-on-natural-products-peer-reviewed-fulltext-article-IJNnatural productsnanotechnologydrug deliverytargeting |
| spellingShingle | Lv Y Li W Liao W Jiang H Liu Y Cao J Lu W Feng Y Nano-Drug Delivery Systems Based on Natural Products International Journal of Nanomedicine natural products nanotechnology drug delivery targeting |
| title | Nano-Drug Delivery Systems Based on Natural Products |
| title_full | Nano-Drug Delivery Systems Based on Natural Products |
| title_fullStr | Nano-Drug Delivery Systems Based on Natural Products |
| title_full_unstemmed | Nano-Drug Delivery Systems Based on Natural Products |
| title_short | Nano-Drug Delivery Systems Based on Natural Products |
| title_sort | nano drug delivery systems based on natural products |
| topic | natural products nanotechnology drug delivery targeting |
| url | https://www.dovepress.com/nano-drug-delivery-systems-based-on-natural-products-peer-reviewed-fulltext-article-IJN |
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