Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study
Background: Few epidemiological studies have investigated associations of exposure to multiple metals with thyroid hormone homeostasis, especially for the pregnant women. Methods: Among all the 1644 participants enrolled in Hangzhou Birth Cohort Study (HBCS) at baseline, a total of 915 pregnant wome...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018310705 |
| _version_ | 1818291902460461056 |
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| author | Jing Guo Na Lv Jun Tang Xue Zhang Lihe Peng Xiaofu Du Shuai Li Qiong Luo Dan Zhang Guangdi Chen |
| author_facet | Jing Guo Na Lv Jun Tang Xue Zhang Lihe Peng Xiaofu Du Shuai Li Qiong Luo Dan Zhang Guangdi Chen |
| author_sort | Jing Guo |
| collection | DOAJ |
| description | Background: Few epidemiological studies have investigated associations of exposure to multiple metals with thyroid hormone homeostasis, especially for the pregnant women. Methods: Among all the 1644 participants enrolled in Hangzhou Birth Cohort Study (HBCS) at baseline, a total of 915 pregnant women with complete data of interest were analyzed. Eleven metals were measured in blood samples collected around 25 weeks gestation. Serum levels of thyroid hormones including free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), total thyroxine (TT4) and thyroid-stimulating hormone (TSH) were abstracted from the medical records. Relationships between tertiles of metal levels (setting the lowest tertile as the reference) and percent changes in thyroid hormones were estimated by multivariable adjusted linear regression models. Results: Five metals [arsenic (As), selenium (Se), manganese (Mn), nickel (Ni), antimony (Sb)] were significantly linked to decreased levels of one or more thyroid hormones based on trend tests in the single-metal models. Percent changes [95% confidence intervals (CIs)] in thyroid hormones for the third tertiles of metals remained significant between FT3 and As [−3.53% (−5.48%, −1.54%)]; and between TT3 and As [−4.19% (−7.00%, −1.31%)]; and between FT4 and Mn [−2.05% (−3.49%, −0.58%)], Sb [−1.99% (−3.44%, −0.52%)] in the multiple-metal models. Conclusions: Thyroid hormone concentrations were reversely related to the levels of blood metals of As, Mn and Sb among Chinese pregnant women. Additional prospective studies are warranted to confirm the causality.Paper capsule: Exposure to multiple metals was reversely associated with one or more thyroid hormones in the Chinese pregnant women. Keywords: Metals, Thyroid hormones, Pregnant women, Cross-sectional study |
| first_indexed | 2024-12-13T02:51:27Z |
| format | Article |
| id | doaj.art-67a9c8dda62a4cd693316445400b70a8 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-13T02:51:27Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-67a9c8dda62a4cd693316445400b70a82022-12-22T00:02:03ZengElsevierEnvironment International0160-41202018-12-0112111851192Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional studyJing Guo0Na Lv1Jun Tang2Xue Zhang3Lihe Peng4Xiaofu Du5Shuai Li6Qiong Luo7Dan Zhang8Guangdi Chen9Department of Public Health, and Department of Reproductive Endocrinology of Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Public Health, and Department of Reproductive Endocrinology of Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaJiashan County Center for Disease Control and Prevention, Jiashan, ChinaJiashan County Center for Disease Control and Prevention, Jiashan, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Clinical Laboratory, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaKey Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Public Health, and Department of Reproductive Endocrinology of Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author at: 866 Yuhangtang Road, POB #45, Zhejiang University School of Medicine, Hangzhou 310058, China.Background: Few epidemiological studies have investigated associations of exposure to multiple metals with thyroid hormone homeostasis, especially for the pregnant women. Methods: Among all the 1644 participants enrolled in Hangzhou Birth Cohort Study (HBCS) at baseline, a total of 915 pregnant women with complete data of interest were analyzed. Eleven metals were measured in blood samples collected around 25 weeks gestation. Serum levels of thyroid hormones including free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), total thyroxine (TT4) and thyroid-stimulating hormone (TSH) were abstracted from the medical records. Relationships between tertiles of metal levels (setting the lowest tertile as the reference) and percent changes in thyroid hormones were estimated by multivariable adjusted linear regression models. Results: Five metals [arsenic (As), selenium (Se), manganese (Mn), nickel (Ni), antimony (Sb)] were significantly linked to decreased levels of one or more thyroid hormones based on trend tests in the single-metal models. Percent changes [95% confidence intervals (CIs)] in thyroid hormones for the third tertiles of metals remained significant between FT3 and As [−3.53% (−5.48%, −1.54%)]; and between TT3 and As [−4.19% (−7.00%, −1.31%)]; and between FT4 and Mn [−2.05% (−3.49%, −0.58%)], Sb [−1.99% (−3.44%, −0.52%)] in the multiple-metal models. Conclusions: Thyroid hormone concentrations were reversely related to the levels of blood metals of As, Mn and Sb among Chinese pregnant women. Additional prospective studies are warranted to confirm the causality.Paper capsule: Exposure to multiple metals was reversely associated with one or more thyroid hormones in the Chinese pregnant women. Keywords: Metals, Thyroid hormones, Pregnant women, Cross-sectional studyhttp://www.sciencedirect.com/science/article/pii/S0160412018310705 |
| spellingShingle | Jing Guo Na Lv Jun Tang Xue Zhang Lihe Peng Xiaofu Du Shuai Li Qiong Luo Dan Zhang Guangdi Chen Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study Environment International |
| title | Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study |
| title_full | Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study |
| title_fullStr | Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study |
| title_full_unstemmed | Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study |
| title_short | Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study |
| title_sort | associations of blood metal exposure with thyroid hormones in chinese pregnant women a cross sectional study |
| url | http://www.sciencedirect.com/science/article/pii/S0160412018310705 |
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