Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia
Abstract Background Diabetes mellitus (DM) is thought to affect tuberculosis (TB) clinical presentation and treatment response. Whether DM impacts radiological manifestations of pulmonary TB is still not clear. This study investigated the impact of glycemic status on radiological manifestations of p...
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-020-4843-0 |
| _version_ | 1818665196385730560 |
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| author | Nadia Nilda Barreda Maria B. Arriaga Juan Gonzalo Aliaga Kattya Lopez Oswaldo Martin Sanabria Thomas A. Carmo José F. Fróes Neto Leonid Lecca Bruno B. Andrade Roger I. Calderon |
| author_facet | Nadia Nilda Barreda Maria B. Arriaga Juan Gonzalo Aliaga Kattya Lopez Oswaldo Martin Sanabria Thomas A. Carmo José F. Fróes Neto Leonid Lecca Bruno B. Andrade Roger I. Calderon |
| author_sort | Nadia Nilda Barreda |
| collection | DOAJ |
| description | Abstract Background Diabetes mellitus (DM) is thought to affect tuberculosis (TB) clinical presentation and treatment response. Whether DM impacts radiological manifestations of pulmonary TB is still not clear. This study investigated the impact of glycemic status on radiological manifestations of pulmonary TB cases and its relationship with concentration of biochemical parameters in peripheral blood. Methods A retrospective cross-sectional study used data from 132 microbiologically confirmed pulmonary TB patients from Lima, Peru, evaluated in a previous investigation performed between February and December 2017. Chest radiographs were analyzed by a radiologist and a pulmonologist. Radiographic lesions were identified as cavities, alveolar infiltrates and fibrous tracts. Hyperglycemia in TB patients was identified by use of fasting plasma glucose, HbA1c and oral glucose tolerance test. Clinical, biochemical and hematological parameters were also analyzed. Results TB patients with hyperglycemia presented more frequently with cavities, alveolar infiltrates and fibrous tracts than those with normoglycemia. Hierarchical clustering analysis indicated that patients with more diverse and higher number of lung lesions exhibited a distinct laboratorial profile characterized by heightened white blood cell counts and circulating levels of total cholesterol, triglycerides and transaminases and simultaneously low levels of albumin and hemoglobin. Multivariable regression analyses adjusted for age, sex, prior TB, hemoglobin levels and acid-fast bacilli ≥2+ in sputum smears, demonstrated that presence of prediabetes or diabetes in TB patients was associated with increased odds of having 3 pulmonary lesion types (p = 0.003 and p < 0.01 respectively) or ≥ 4 lesions (p = 0.001 and p = 0.01 respectively). Conclusion Hyperglycemia (both DM and prediabetes) significantly affected the presentation of radiographic manifestations and the number of lesions in pulmonary TB patients as well as the biochemical profile in peripheral blood. |
| first_indexed | 2024-12-17T05:44:47Z |
| format | Article |
| id | doaj.art-67aa8d9d0e324362a94e764677c2281a |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-17T05:44:47Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-67aa8d9d0e324362a94e764677c2281a2022-12-21T22:01:21ZengBMCBMC Infectious Diseases1471-23342020-02-0120111410.1186/s12879-020-4843-0Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemiaNadia Nilda Barreda0Maria B. Arriaga1Juan Gonzalo Aliaga2Kattya Lopez3Oswaldo Martin Sanabria4Thomas A. Carmo5José F. Fróes Neto6Leonid Lecca7Bruno B. Andrade8Roger I. Calderon9Socios En Salud Sucursal PeruFaculdade de Medicina, Universidade Federal da BahiaSocios En Salud Sucursal PeruSocios En Salud Sucursal PeruSocios En Salud Sucursal PeruMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José SilveiraMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José SilveiraSocios En Salud Sucursal PeruFaculdade de Medicina, Universidade Federal da BahiaSocios En Salud Sucursal PeruAbstract Background Diabetes mellitus (DM) is thought to affect tuberculosis (TB) clinical presentation and treatment response. Whether DM impacts radiological manifestations of pulmonary TB is still not clear. This study investigated the impact of glycemic status on radiological manifestations of pulmonary TB cases and its relationship with concentration of biochemical parameters in peripheral blood. Methods A retrospective cross-sectional study used data from 132 microbiologically confirmed pulmonary TB patients from Lima, Peru, evaluated in a previous investigation performed between February and December 2017. Chest radiographs were analyzed by a radiologist and a pulmonologist. Radiographic lesions were identified as cavities, alveolar infiltrates and fibrous tracts. Hyperglycemia in TB patients was identified by use of fasting plasma glucose, HbA1c and oral glucose tolerance test. Clinical, biochemical and hematological parameters were also analyzed. Results TB patients with hyperglycemia presented more frequently with cavities, alveolar infiltrates and fibrous tracts than those with normoglycemia. Hierarchical clustering analysis indicated that patients with more diverse and higher number of lung lesions exhibited a distinct laboratorial profile characterized by heightened white blood cell counts and circulating levels of total cholesterol, triglycerides and transaminases and simultaneously low levels of albumin and hemoglobin. Multivariable regression analyses adjusted for age, sex, prior TB, hemoglobin levels and acid-fast bacilli ≥2+ in sputum smears, demonstrated that presence of prediabetes or diabetes in TB patients was associated with increased odds of having 3 pulmonary lesion types (p = 0.003 and p < 0.01 respectively) or ≥ 4 lesions (p = 0.001 and p = 0.01 respectively). Conclusion Hyperglycemia (both DM and prediabetes) significantly affected the presentation of radiographic manifestations and the number of lesions in pulmonary TB patients as well as the biochemical profile in peripheral blood.https://doi.org/10.1186/s12879-020-4843-0Chest x-rayHyperglycemiaDiabetes mellitusPrediabetesPulmonary tuberculosis |
| spellingShingle | Nadia Nilda Barreda Maria B. Arriaga Juan Gonzalo Aliaga Kattya Lopez Oswaldo Martin Sanabria Thomas A. Carmo José F. Fróes Neto Leonid Lecca Bruno B. Andrade Roger I. Calderon Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia BMC Infectious Diseases Chest x-ray Hyperglycemia Diabetes mellitus Prediabetes Pulmonary tuberculosis |
| title | Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia |
| title_full | Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia |
| title_fullStr | Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia |
| title_full_unstemmed | Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia |
| title_short | Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia |
| title_sort | severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia |
| topic | Chest x-ray Hyperglycemia Diabetes mellitus Prediabetes Pulmonary tuberculosis |
| url | https://doi.org/10.1186/s12879-020-4843-0 |
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