DNA-Based Molecular Engineering of the Cell Membrane
The cell membrane serves as a barrier and gatekeeper to regulate the cellular transportation of substances and information. It plays a significant role in protecting the cell from the extracellular environment, maintaining intracellular homeostasis, and regulating cellular function and behaviors. Th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/12/2/111 |
| _version_ | 1797478194335449088 |
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| author | Xiaodong Li Tiantian Wang Yue Sun Chang Li Tianhuan Peng Liping Qiu |
| author_facet | Xiaodong Li Tiantian Wang Yue Sun Chang Li Tianhuan Peng Liping Qiu |
| author_sort | Xiaodong Li |
| collection | DOAJ |
| description | The cell membrane serves as a barrier and gatekeeper to regulate the cellular transportation of substances and information. It plays a significant role in protecting the cell from the extracellular environment, maintaining intracellular homeostasis, and regulating cellular function and behaviors. The capability to engineer the cell membrane with functional modules that enable dynamic monitoring and manipulating the cell-surface microenvironment would be critical for studying molecular mechanisms underlying various biological processes. To meet this goal, DNA, with intrinsic advantages of high versatility, programmability, and biocompatibility, has gained intense attention as a molecular tool for cell-surface engineering. The past three decades have witnessed the rapid advances of diverse nucleic acid materials, including functional nucleic acids (FNAs), dynamic DNA circuits, and exquisite DNA nanostructures. In this mini review, we have summarized the recent progress of DNA technology for cell membrane engineering, particularly focused on their applications for molecular sensing and imaging, precise cell identification, receptor activity regulation, and artificial membrane structures. Furthermore, we discussed the challenge and outlook on using nucleic acid materials in this specific research area. |
| first_indexed | 2024-03-09T21:28:33Z |
| format | Article |
| id | doaj.art-67aac65323874d2f98e5c0d8cdd01f30 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T21:28:33Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-67aac65323874d2f98e5c0d8cdd01f302023-11-23T21:01:59ZengMDPI AGMembranes2077-03752022-01-0112211110.3390/membranes12020111DNA-Based Molecular Engineering of the Cell MembraneXiaodong Li0Tiantian Wang1Yue Sun2Chang Li3Tianhuan Peng4Liping Qiu5Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, ChinaMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, ChinaMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, ChinaMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, ChinaMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, ChinaMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, ChinaThe cell membrane serves as a barrier and gatekeeper to regulate the cellular transportation of substances and information. It plays a significant role in protecting the cell from the extracellular environment, maintaining intracellular homeostasis, and regulating cellular function and behaviors. The capability to engineer the cell membrane with functional modules that enable dynamic monitoring and manipulating the cell-surface microenvironment would be critical for studying molecular mechanisms underlying various biological processes. To meet this goal, DNA, with intrinsic advantages of high versatility, programmability, and biocompatibility, has gained intense attention as a molecular tool for cell-surface engineering. The past three decades have witnessed the rapid advances of diverse nucleic acid materials, including functional nucleic acids (FNAs), dynamic DNA circuits, and exquisite DNA nanostructures. In this mini review, we have summarized the recent progress of DNA technology for cell membrane engineering, particularly focused on their applications for molecular sensing and imaging, precise cell identification, receptor activity regulation, and artificial membrane structures. Furthermore, we discussed the challenge and outlook on using nucleic acid materials in this specific research area.https://www.mdpi.com/2077-0375/12/2/111functional nucleic acidsDNA nanotechnologycell membrane engineering |
| spellingShingle | Xiaodong Li Tiantian Wang Yue Sun Chang Li Tianhuan Peng Liping Qiu DNA-Based Molecular Engineering of the Cell Membrane Membranes functional nucleic acids DNA nanotechnology cell membrane engineering |
| title | DNA-Based Molecular Engineering of the Cell Membrane |
| title_full | DNA-Based Molecular Engineering of the Cell Membrane |
| title_fullStr | DNA-Based Molecular Engineering of the Cell Membrane |
| title_full_unstemmed | DNA-Based Molecular Engineering of the Cell Membrane |
| title_short | DNA-Based Molecular Engineering of the Cell Membrane |
| title_sort | dna based molecular engineering of the cell membrane |
| topic | functional nucleic acids DNA nanotechnology cell membrane engineering |
| url | https://www.mdpi.com/2077-0375/12/2/111 |
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