Mucinous urothelial carcinoma of the renal pelvis

Urothelial carcinoma with abundant myxoid stroma is a newly-described and extremely rare entity. Since only very few cases have been reported, there is no consensus on its nomenclature. Microscopic examination revealed invasive urothelial carcinoma with widespread low-grade noninvasive areas. There...

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Main Authors: Kemal Behzatoğlu, Ceren Boyacı, Oğuzhan Okçu, Ezgi Hacıhasanoğlu, Yasemin Çakır, Seher Darakçı
Format: Article
Language:English
Published: SAGE Publishing 2014-12-01
Series:Rare Tumors
Subjects:
Online Access:http://www.pagepress.org/journals/index.php/rt/article/view/5485
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author Kemal Behzatoğlu
Ceren Boyacı
Oğuzhan Okçu
Ezgi Hacıhasanoğlu
Yasemin Çakır
Seher Darakçı
author_facet Kemal Behzatoğlu
Ceren Boyacı
Oğuzhan Okçu
Ezgi Hacıhasanoğlu
Yasemin Çakır
Seher Darakçı
author_sort Kemal Behzatoğlu
collection DOAJ
description Urothelial carcinoma with abundant myxoid stroma is a newly-described and extremely rare entity. Since only very few cases have been reported, there is no consensus on its nomenclature. Microscopic examination revealed invasive urothelial carcinoma with widespread low-grade noninvasive areas. There were focal invasive areas in the neighborhood of the renal parenchyma. Malignant urothelial tumor/cell groups localized in the stroma had abundant myxoid/mucinous background in the invasive areas. The cytoplasm of the tumoral cells was more eosinophilic in these areas and the cells formed small groups and cords. Histochemically, PAS and Alcian Blue were positive in the cytoplasm of the tumoral cells and in the stroma while negative in the non-mucinous areas. Immunohistochemically, the tumoral cells of the mucinous invasive areas diffusely expressed MUC1 and MUC2. We discuss the origin of the mucinous/myxoid stroma, the tumor’s nature and its nomenclature with histochemical and immunohistochemical features.
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spelling doaj.art-67aad33074084f0cb0298c9603a1ee672022-12-21T23:39:50ZengSAGE PublishingRare Tumors2036-36052036-36132014-12-016410.4081/rt.2014.54852962Mucinous urothelial carcinoma of the renal pelvisKemal Behzatoğlu0Ceren Boyacı1Oğuzhan Okçu2Ezgi Hacıhasanoğlu3Yasemin Çakır4Seher Darakçı5Department of Pathology, Istanbul Education and Research Hospital, IstanbulDepartment of Pathology, Istanbul Education and Research Hospital, IstanbulDepartment of Pathology, Istanbul Education and Research Hospital, IstanbulDepartment of Pathology, Istanbul Education and Research Hospital, IstanbulDepartment of Pathology, Istanbul Education and Research Hospital, IstanbulDepartment of Pathology, Istanbul Education and Research Hospital, IstanbulUrothelial carcinoma with abundant myxoid stroma is a newly-described and extremely rare entity. Since only very few cases have been reported, there is no consensus on its nomenclature. Microscopic examination revealed invasive urothelial carcinoma with widespread low-grade noninvasive areas. There were focal invasive areas in the neighborhood of the renal parenchyma. Malignant urothelial tumor/cell groups localized in the stroma had abundant myxoid/mucinous background in the invasive areas. The cytoplasm of the tumoral cells was more eosinophilic in these areas and the cells formed small groups and cords. Histochemically, PAS and Alcian Blue were positive in the cytoplasm of the tumoral cells and in the stroma while negative in the non-mucinous areas. Immunohistochemically, the tumoral cells of the mucinous invasive areas diffusely expressed MUC1 and MUC2. We discuss the origin of the mucinous/myxoid stroma, the tumor’s nature and its nomenclature with histochemical and immunohistochemical features.http://www.pagepress.org/journals/index.php/rt/article/view/5485mucinous, myxoid, urothelial carcinoma, renal pelvis, MUCs
spellingShingle Kemal Behzatoğlu
Ceren Boyacı
Oğuzhan Okçu
Ezgi Hacıhasanoğlu
Yasemin Çakır
Seher Darakçı
Mucinous urothelial carcinoma of the renal pelvis
Rare Tumors
mucinous, myxoid, urothelial carcinoma, renal pelvis, MUCs
title Mucinous urothelial carcinoma of the renal pelvis
title_full Mucinous urothelial carcinoma of the renal pelvis
title_fullStr Mucinous urothelial carcinoma of the renal pelvis
title_full_unstemmed Mucinous urothelial carcinoma of the renal pelvis
title_short Mucinous urothelial carcinoma of the renal pelvis
title_sort mucinous urothelial carcinoma of the renal pelvis
topic mucinous, myxoid, urothelial carcinoma, renal pelvis, MUCs
url http://www.pagepress.org/journals/index.php/rt/article/view/5485
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AT cerenboyacı mucinousurothelialcarcinomaoftherenalpelvis
AT oguzhanokcu mucinousurothelialcarcinomaoftherenalpelvis
AT ezgihacıhasanoglu mucinousurothelialcarcinomaoftherenalpelvis
AT yasemincakır mucinousurothelialcarcinomaoftherenalpelvis
AT seherdarakcı mucinousurothelialcarcinomaoftherenalpelvis