A new genotype imputation method with tolerance to high missing rate and rare variants.

A new genotype imputation method with tolerance to high missing rate and rare variants.

We report a novel algorithm, iBLUP, to impute missing genotypes by simultaneously and comprehensively using identity by descent and linkage disequilibrium information. The simulation studies showed that the algorithm exhibited drastically tolerance to high missing rate, especially for rare variants...

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Bibliographic Details
Main Authors: Yumei Yang, Qishan Wang, Qiang Chen, Rongrong Liao, Xiangzhe Zhang, Hongjie Yang, Youmin Zheng, Zhiwu Zhang, Yuchun Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4074155?pdf=render

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