Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan.
BACKGROUND: Chronic feeding and sleep schedule disturbances are stressors that exert damaging effects on the organism. Practicing Muslims in Saudi Arabia go through strict Ramadan fasting from dawn till sunset for one month yearly. Modern era Ramadan practices in Saudi Arabia are associated with dis...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3630175?pdf=render |
| _version_ | 1818487338473357312 |
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| author | Suhad Bahijri Anwar Borai Ghada Ajabnoor Altaf Abdul Khaliq Ibrahim AlQassas Dhafer Al-Shehri George Chrousos |
| author_facet | Suhad Bahijri Anwar Borai Ghada Ajabnoor Altaf Abdul Khaliq Ibrahim AlQassas Dhafer Al-Shehri George Chrousos |
| author_sort | Suhad Bahijri |
| collection | DOAJ |
| description | BACKGROUND: Chronic feeding and sleep schedule disturbances are stressors that exert damaging effects on the organism. Practicing Muslims in Saudi Arabia go through strict Ramadan fasting from dawn till sunset for one month yearly. Modern era Ramadan practices in Saudi Arabia are associated with disturbed feeding and sleep patterns, namely abstaining from food and water and increasing daytime sleep, and staying awake and receiving food and water till dawn. HYPOTHESIS: Strict Ramadan practices in Saudi Arabia may influence metabolism, sleep and circadian cortisol secretion. PROTOCOL: Young, male Ramadan practitioners were evaluated before and two weeks into the Ramadan. Blood samples were collected at 9.00 am and 9.00 pm for measurements of metabolic parameters and cortisol. Saliva was collected serially during the day for cortisol determinations. RESULTS: Ramadan practitioners had relative metabolic stability or changes expected by the pattern of feeding. However, the cortisol circadian rhythm was abolished and circulating insulin levels and HOMA index were increased during this period. DISCUSSION: The flattening of the cortisol rhythm is typical of conditions associated with chronic stress or endogenous hypercortisolism and associated with insulin resistance. CONCLUSIONS: Modern Ramadan practices in Saudi Arabia are associated with evening hypercortisolism and increased insulin resistance. These changes might contribute to the high prevalence of chronic stress-related conditions, such as central obesity, hypertension, metabolic syndrome and diabetes mellitus type 2, and their cardiovascular sequelae observed in the Kingdom. |
| first_indexed | 2024-12-10T16:36:31Z |
| format | Article |
| id | doaj.art-67ac1aab654044e8b6f473bdb450afa5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T16:36:31Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-67ac1aab654044e8b6f473bdb450afa52022-12-22T01:41:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6091710.1371/journal.pone.0060917Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan.Suhad BahijriAnwar BoraiGhada AjabnoorAltaf Abdul KhaliqIbrahim AlQassasDhafer Al-ShehriGeorge ChrousosBACKGROUND: Chronic feeding and sleep schedule disturbances are stressors that exert damaging effects on the organism. Practicing Muslims in Saudi Arabia go through strict Ramadan fasting from dawn till sunset for one month yearly. Modern era Ramadan practices in Saudi Arabia are associated with disturbed feeding and sleep patterns, namely abstaining from food and water and increasing daytime sleep, and staying awake and receiving food and water till dawn. HYPOTHESIS: Strict Ramadan practices in Saudi Arabia may influence metabolism, sleep and circadian cortisol secretion. PROTOCOL: Young, male Ramadan practitioners were evaluated before and two weeks into the Ramadan. Blood samples were collected at 9.00 am and 9.00 pm for measurements of metabolic parameters and cortisol. Saliva was collected serially during the day for cortisol determinations. RESULTS: Ramadan practitioners had relative metabolic stability or changes expected by the pattern of feeding. However, the cortisol circadian rhythm was abolished and circulating insulin levels and HOMA index were increased during this period. DISCUSSION: The flattening of the cortisol rhythm is typical of conditions associated with chronic stress or endogenous hypercortisolism and associated with insulin resistance. CONCLUSIONS: Modern Ramadan practices in Saudi Arabia are associated with evening hypercortisolism and increased insulin resistance. These changes might contribute to the high prevalence of chronic stress-related conditions, such as central obesity, hypertension, metabolic syndrome and diabetes mellitus type 2, and their cardiovascular sequelae observed in the Kingdom.http://europepmc.org/articles/PMC3630175?pdf=render |
| spellingShingle | Suhad Bahijri Anwar Borai Ghada Ajabnoor Altaf Abdul Khaliq Ibrahim AlQassas Dhafer Al-Shehri George Chrousos Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan. PLoS ONE |
| title | Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan. |
| title_full | Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan. |
| title_fullStr | Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan. |
| title_full_unstemmed | Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan. |
| title_short | Relative metabolic stability, but disrupted circadian cortisol secretion during the fasting month of Ramadan. |
| title_sort | relative metabolic stability but disrupted circadian cortisol secretion during the fasting month of ramadan |
| url | http://europepmc.org/articles/PMC3630175?pdf=render |
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