The association of megalin and cubilin genetic variants with serum levels of 25-hydroxvitamin D and the incidence of acute coronary syndrome in Egyptians: A case control study

The association of megalin and cubilin genetic variants with serum levels of 25-hydroxvitamin D and the incidence of acute coronary syndrome in Egyptians: A case control study

Megalin and cubilin are two receptors that mediate endocytosis of 25-hydroxyvitamin D (25(OH)D) for its final activation by hydroxylation. The aim of the present study was to evaluate the association of polymorphisms in megalin (rs2075252 and rs4668123) and cubilin (rs1801222 and rs12766939) with th...

Full description

Bibliographic Details
Main Authors:	Raghda A. Elsabbagh, Mohamed F. Abdel Rahman, Sally I. Hassanein, Rasha S. Hanafi, Reem A. Assal, Gamal M. Shaban, Mohamed Z. Gad
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Series:	Journal of Advanced Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S2090123219301584

Similar Items

Megalin and cubilin expression in gallbladder epithelium and regulation by bile acids
by: Benjamín Erranz, et al.
Published: (2004-12-01)

Spatio-temporal expression of membrane transporters, Megalin and Cubilin, in renal development of C57BL/6 mice
by: LUO Mei, et al.
Published: (2024-03-01)

Inhibiting miRNA-146a suppresses mouse gallstone formation by regulating LXR/megalin/cubilin-media cholesterol absorption
by: Bin Yang, et al.
Published: (2024-09-01)

Immunoexpression Patterns of Megalin, Cubilin, Caveolin-1, Gipc1 and Dab2IP in the Embryonic and Postnatal Development of the Kidneys in <i>Yotari</i> (<i>Dab1</i><sup>−/−</sup>) Mice
by: Sani Žužul, et al.
Published: (2024-07-01)

Microarray analysis of E9.5 reduced folate carrier (<it>RFC1; Slc19a1</it>) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex
by: Bauer Linda K, et al.
Published: (2008-04-01)

Isolated benign persistent proteinuria with novel association of CUBN (cubilin) variants
by: Vivian Shi, et al.
Published: (2023-06-01)

Evidence for the role of megalin in renal uptake of transthyretin.
by: Sousa, M, et al.
Published: (2000)

Megalin Orchestrates FcRn Endocytosis and Trafficking
by: Eileen Dahlke, et al.
Published: (2022-12-01)

Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study
by: Satoshi Shoji, et al.
Published: (2019-12-01)

dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
by: Xiaoming Feng, et al.
Published: (2021-09-01)

Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex
by: Lisa Gianesello, et al.
Published: (2017-10-01)

Determination of Capecitabine and Its Metabolites in Plasma of Egyptian Colorectal Cancer Patients
by: Sara Shamseldin, et al.
Published: (2023-10-01)

Luminal expression of cubilin is impaired in Imerslund-Gräsbeck syndrome with compound AMN mutations in intron 3 and exon 7
by: Fares Namour, et al.
Published: (2011-11-01)

A frameshift mutation in the cubilin gene (CUBN) in Border Collies with Imerslund-Gräsbeck syndrome (selective cobalamin malabsorption).
by: Marta Owczarek-Lipska, et al.
Published: (2013-01-01)

Is there a correlation between -174(G/C) polymorphism of IL-6 gene and the incidence of acute myocardial infarction?
by: Ingy M. Hashad, et al.
Published: (2021-09-01)

Significance of urinary full-length megalin in patients with IgA nephropathy.
by: Takuto Seki, et al.
Published: (2014-01-01)

Phenotypic and genotypic detection of resistance mechanisms in carbapenem-resistant gram-negative bacteria isolated from Egyptian ICU patients with first emergence of NDM-1 producing Klebsiella oxytoca
by: Reem Hossam Fawzy, et al.
Published: (2022-12-01)

Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome.
by: Norden, A, et al.
Published: (2002)

Serum megalin levels in type-2 diabetes mellitus with and without cardiovascular disease
by: Sujatha Rajaragupathy, et al.
Published: (2024-11-01)

Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorption
by: Rodrigo A. S. Peres, et al.
Published: (2023-07-01)

Influenza virus decreases albumin uptake and megalin expression in alveolar epithelial cells
by: Andrés Alberro-Brage, et al.
Published: (2023-09-01)

The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells
by: Shankhajit De, et al.
Published: (2014-07-01)

Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats.
by: Danny Jensen, et al.
Published: (2017-01-01)

The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells
by: Andres E. Perez Bay, et al.
Published: (2016-05-01)

Evaluation of the Green Egyptian Pyramid
by: Mohamed Gamal Ammar
Published: (2012-12-01)

Incidence of hepatitis C virus infection among people living with HIV: An Egyptian cohort study
by: Fatma Elrashdy, et al.
Published: (2022-11-01)

Arterial supply of the stomach of the Egyptian native goat
by: Reda Mohamed, et al.
Published: (2017-03-01)

LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin
by: Yao Zhou, et al.
Published: (2022-09-01)

Hepatocyte nuclear factor 4α regulates megalin expression in proximal tubular cells
by: Shota Sasaki, et al.
Published: (2019-03-01)

First description of subglacial megalineations from the late Paleozoic ice age in southern Africa.
by: Graham D Andrews, et al.
Published: (2019-01-01)

Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome
by: Jing Wang, et al.
Published: (2017-06-01)

Impact of N6-methyladenosine (m6A) modification on immunity
by: Raghda A. Elsabbagh, et al.
Published: (2022-09-01)

Angiotensinogen Gene (M235T) Variant and Pre-Eclampsia in Egyptian Pregnant Women
by: Nargues Hassanein, et al.
Published: (2007-09-01)

Analytical Study of The Islamic and Ancient Egyptian Influences on The Library of Alexandria
by: Fatima Ahmed Abdo Hassanein, et al.
Published: (2023-09-01)

Urinary megalin levels in patients with type 2 diabetic nephropathy and its correlation with renal function
by: Sudharshan Jagennath, et al.
Published: (2024-01-01)

Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content
by: L. R. Rega, et al.
Published: (2023-10-01)

Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge
by: Fernando Bartolome, et al.
Published: (2020-01-01)

Megalin-targeted acetylcysteine polymeric prodrug ameliorates ischemia-reperfusion-induced acute kidney injury
by: Hao-Le Huang, et al.
Published: (2024-05-01)

Incidence of retinal redetachment after silicone oil removal in cases of severe eye injuries operated during the 25th of January Egyptian Revolution
by: Ahmed M Abdel Hadi
Published: (2015-01-01)

Genotyping of carbapenem resistant Acinetobacter baumannii isolated from Egyptian patients
by: Heba Ahmed Mohamed, et al.
Published: (2022-12-01)