Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration

Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration

Down Syndrome (DS) Cell Adhesion Molecules (DSCAMs) are transmembrane proteins of the immunoglobulin superfamily. Human DSCAM is located within the DS critical region of chromosome 21 (duplicated in Down Syndrome patients), and mutations or copy-number variations of this gene have also been associat...

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Bibliographic Details
Main Authors: Manuela D. Mitsogiannis, Anna Pancho, Tania Aerts, Sonja M. Sachse, Ria Vanlaer, Lut Noterdaeme, Dietmar Schmucker, Eve Seuntjens
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Dscam
Dscaml1
neuronal migration
cell adhesion
telencephalic development
radial migration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.624181/full

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