Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation
Stiffening of central conduit arteries –areas where the mechanoreceptors are embedded (e.g., ascending aorta and carotid artery) – is considered to be associated with the impaired baroreflex control in response to hypotensive stress. Arterial stiffness is modulated by vascular tone transiently and d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | Artery Research |
| Subjects: | |
| Online Access: | https://www.atlantis-press.com/article/125929740/view |
| _version_ | 1817982899674152960 |
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| author | Jun Sugawara Christopher K. Willie Taiki Miyazawa Hidehiko Komine Philip N. Ainsle Shigehiko Ogoh |
| author_facet | Jun Sugawara Christopher K. Willie Taiki Miyazawa Hidehiko Komine Philip N. Ainsle Shigehiko Ogoh |
| author_sort | Jun Sugawara |
| collection | DOAJ |
| description | Stiffening of central conduit arteries –areas where the mechanoreceptors are embedded (e.g., ascending aorta and carotid artery) – is considered to be associated with the impaired baroreflex control in response to hypotensive stress. Arterial stiffness is modulated by vascular tone transiently and dynamically, however, it is unknown whether a transient change in the carotid artery stiffness influences the cardiac baroreflex response to a rapid hypotension. We measured (n = 11) carotid arterial stiffness (via concurrent applanation tonometory and ultrasound imaging) at supine rest and during 20-degree head-up tilt (HUT). To evaluate the cardiac baroreflex response, acute hypotension was evoked by releasing bilateral thigh cuffs after 3 min of suprasystolic resting ischemia at each posture; cardiac baroreflex sensitivity (e.g., change in heart rate for a given change in mean arterial pressure, ΔHR/ΔMAP) and latency (e.g., the time to peak HR response) was estimated. Carotid β-stiffness index, a measure of arterial stiffness, was reduced by 14% during HUT (P < 0.05 vs. supine position). Although cardiac baroreflex responses were unaltered, the within-group biological variability in the cardiac baroreflex sensitivity and latency from the supine to HUT was correlated with the corresponding changes in carotid arterial stiffness (r = 0.66 and r = 0.64, respectively, both P < 0.05). These findings suggest that a transient change in carotid arterial stiffness, at least in part, influences changes in the cardiac baroreflex response to a rapid hypotension. |
| first_indexed | 2024-04-13T23:27:05Z |
| format | Article |
| id | doaj.art-67af69c0b2014c0088257d421a94fef5 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-13T23:27:05Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-67af69c0b2014c0088257d421a94fef52022-12-22T02:25:02ZengBMCArtery Research1876-44012012-06-016310.1016/j.artres.2012.05.002Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulationJun SugawaraChristopher K. WillieTaiki MiyazawaHidehiko KominePhilip N. AinsleShigehiko OgohStiffening of central conduit arteries –areas where the mechanoreceptors are embedded (e.g., ascending aorta and carotid artery) – is considered to be associated with the impaired baroreflex control in response to hypotensive stress. Arterial stiffness is modulated by vascular tone transiently and dynamically, however, it is unknown whether a transient change in the carotid artery stiffness influences the cardiac baroreflex response to a rapid hypotension. We measured (n = 11) carotid arterial stiffness (via concurrent applanation tonometory and ultrasound imaging) at supine rest and during 20-degree head-up tilt (HUT). To evaluate the cardiac baroreflex response, acute hypotension was evoked by releasing bilateral thigh cuffs after 3 min of suprasystolic resting ischemia at each posture; cardiac baroreflex sensitivity (e.g., change in heart rate for a given change in mean arterial pressure, ΔHR/ΔMAP) and latency (e.g., the time to peak HR response) was estimated. Carotid β-stiffness index, a measure of arterial stiffness, was reduced by 14% during HUT (P < 0.05 vs. supine position). Although cardiac baroreflex responses were unaltered, the within-group biological variability in the cardiac baroreflex sensitivity and latency from the supine to HUT was correlated with the corresponding changes in carotid arterial stiffness (r = 0.66 and r = 0.64, respectively, both P < 0.05). These findings suggest that a transient change in carotid arterial stiffness, at least in part, influences changes in the cardiac baroreflex response to a rapid hypotension.https://www.atlantis-press.com/article/125929740/viewArterial complianceCarotid-vagal baroreflexHead-up tilt |
| spellingShingle | Jun Sugawara Christopher K. Willie Taiki Miyazawa Hidehiko Komine Philip N. Ainsle Shigehiko Ogoh Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation Artery Research Arterial compliance Carotid-vagal baroreflex Head-up tilt |
| title | Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation |
| title_full | Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation |
| title_fullStr | Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation |
| title_full_unstemmed | Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation |
| title_short | Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation |
| title_sort | effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation |
| topic | Arterial compliance Carotid-vagal baroreflex Head-up tilt |
| url | https://www.atlantis-press.com/article/125929740/view |
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