Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences. Inhibitors of cyclooxygenase-2 (COX-2) are potential...

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Bibliographic Details
Main Authors: Markus Laube, Torsten Kniess, Jens Pietzsch
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Antioxidants
Subjects:
COX-2 inhibitors (COXIBs)
cyclooxygenases
normal tissue
nonsteroidal anti-inflammatory drugs (NSAIDS)
oxidative stress
radiation-induced vascular dysfunction
radioprotection
radiosensitization
reactive oxygen/nitrogen species
tumor models
Online Access:http://www.mdpi.com/2076-3921/5/2/14

Internet

http://www.mdpi.com/2076-3921/5/2/14

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