Pretargeted Molecular Imaging and Radioimmunotherapy
<p>Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb) localize within a tumor by virtue of its anti-tumor binding site(s) before administering a small, fast-clearing radiolabeled compound that then attaches to the other portion of the bsMAb. The compou...
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| Format: | Article |
| Language: | English |
| Published: |
Ivyspring International Publisher
2012-01-01
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| Series: | Theranostics |
| Online Access: | http://www.thno.org/v02p0523.htm |
| _version_ | 1818290985636986880 |
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| author | David M. Goldenberg, Chien-Hsing Chang, Edmund A. Rossi, William J, McBride, Robert M. Sharkey |
| author_facet | David M. Goldenberg, Chien-Hsing Chang, Edmund A. Rossi, William J, McBride, Robert M. Sharkey |
| author_sort | David M. Goldenberg, Chien-Hsing Chang, Edmund A. Rossi, William J, McBride, Robert M. Sharkey |
| collection | DOAJ |
| description | <p>Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb) localize within a tumor by virtue of its anti-tumor binding site(s) before administering a small, fast-clearing radiolabeled compound that then attaches to the other portion of the bsMAb. The compound's rapid clearance significantly reduces radiation exposure outside of the tumor and its small size permits speedy delivery to the tumor, creating excellent tumor/nontumor ratios in less than 1 hour. Haptens that bind to an anti-hapten antibody, biotin that binds to streptavidin, or an oligonucleotide binding to a complementary oligonucleotide sequence have all been radiolabeled for use by pretargeting. This review will focus on a highly flexible anti-hapten bsMAb platform that has been used to target a variety of radionuclides to image (SPECT and PET) as well as treat tumors.</p> |
| first_indexed | 2024-12-13T02:36:52Z |
| format | Article |
| id | doaj.art-67b601fe59b84ea48a44da332b918cde |
| institution | Directory Open Access Journal |
| issn | 1838-7640 |
| language | English |
| last_indexed | 2024-12-13T02:36:52Z |
| publishDate | 2012-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | Theranostics |
| spelling | doaj.art-67b601fe59b84ea48a44da332b918cde2022-12-22T00:02:23ZengIvyspring International PublisherTheranostics1838-76402012-01-0121523540Pretargeted Molecular Imaging and RadioimmunotherapyDavid M. Goldenberg, Chien-Hsing Chang, Edmund A. Rossi, William J, McBride, Robert M. Sharkey<p>Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb) localize within a tumor by virtue of its anti-tumor binding site(s) before administering a small, fast-clearing radiolabeled compound that then attaches to the other portion of the bsMAb. The compound's rapid clearance significantly reduces radiation exposure outside of the tumor and its small size permits speedy delivery to the tumor, creating excellent tumor/nontumor ratios in less than 1 hour. Haptens that bind to an anti-hapten antibody, biotin that binds to streptavidin, or an oligonucleotide binding to a complementary oligonucleotide sequence have all been radiolabeled for use by pretargeting. This review will focus on a highly flexible anti-hapten bsMAb platform that has been used to target a variety of radionuclides to image (SPECT and PET) as well as treat tumors.</p>http://www.thno.org/v02p0523.htm |
| spellingShingle | David M. Goldenberg, Chien-Hsing Chang, Edmund A. Rossi, William J, McBride, Robert M. Sharkey Pretargeted Molecular Imaging and Radioimmunotherapy Theranostics |
| title | Pretargeted Molecular Imaging and Radioimmunotherapy |
| title_full | Pretargeted Molecular Imaging and Radioimmunotherapy |
| title_fullStr | Pretargeted Molecular Imaging and Radioimmunotherapy |
| title_full_unstemmed | Pretargeted Molecular Imaging and Radioimmunotherapy |
| title_short | Pretargeted Molecular Imaging and Radioimmunotherapy |
| title_sort | pretargeted molecular imaging and radioimmunotherapy |
| url | http://www.thno.org/v02p0523.htm |
| work_keys_str_mv | AT davidmgoldenbergchienhsingchangedmundarossiwilliamjmcbriderobertmsharkey pretargetedmolecularimagingandradioimmunotherapy |