Next generation genetically encoded fluorescent sensors for serotonin

Genetically encoded sensors have been developed and become versatile tools for imaging serotonin dynamics. Here, authors developed a family of serotonin (5-HT) sensors (sDarken), three variants with different affinities for 5-HT enable high spatiotemporal resolution of 5-HT dynamics.

Bibliographic Details
Main Authors: Martin Kubitschke, Monika Müller, Lutz Wallhorn, Mauro Pulin, Manuel Mittag, Stefan Pollok, Tim Ziebarth, Svenja Bremshey, Jill Gerdey, Kristin Carolin Claussen, Kim Renken, Juliana Groß, Pascal Gneiße, Niklas Meyer, J. Simon Wiegert, Andreas Reiner, Martin Fuhrmann, Olivia Andrea Masseck
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35200-w