The role of CD44 in the pathophysiology of chronic lymphocytic leukemia
CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of CD44 standard and variant forms and their functional interplay with hyaluronan is less understood in hematological m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00177/full |
| _version_ | 1818127818231382016 |
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| author | Julia Christine Gutjahr Julia Christine Gutjahr Richard eGreil Richard eGreil Tanja Nicole Hartmann Tanja Nicole Hartmann |
| author_facet | Julia Christine Gutjahr Julia Christine Gutjahr Richard eGreil Richard eGreil Tanja Nicole Hartmann Tanja Nicole Hartmann |
| author_sort | Julia Christine Gutjahr |
| collection | DOAJ |
| description | CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of CD44 standard and variant forms and their functional interplay with hyaluronan is less understood in hematological malignancies. Chronic lymphocytic leukemia (CLL) is a highly abundant B cell malignancy with a well coordinated balance between cell cycle-arrest and proliferation of tumor subpopulations. The long-term survival and proliferation of CLL cells requires their dynamic interactions with stromal and immune cells in lymphoid organs. Interactions of HA with CD44 and HA-mediated motility receptor (RHAMM) contribute to CLL cell localization, and hence CLL pathophysiology, by shaping homing, interstitial migration, and adhesion of the tumor cells. CD44 can complex with key prognostic factors of CLL, particularly CD38 and CD49d, bridging the gap between prognosis and cellular function. Here, we review the current evidence for the individual and associated contributions of CD44 to CLL pathophysiology, the dynamic functional regulation of CD44 upon CLL cell activation, and possible therapeutic strategies targeting CD44 in CLL. |
| first_indexed | 2024-12-11T07:23:24Z |
| format | Article |
| id | doaj.art-67b88bde08fa401b8d9a316a156ed606 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T07:23:24Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-67b88bde08fa401b8d9a316a156ed6062022-12-22T01:16:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-04-01610.3389/fimmu.2015.00177136284The role of CD44 in the pathophysiology of chronic lymphocytic leukemiaJulia Christine Gutjahr0Julia Christine Gutjahr1Richard eGreil2Richard eGreil3Tanja Nicole Hartmann4Tanja Nicole Hartmann5Paracelsus Medical UniversitySalzburg Cancer Research InstituteParacelsus Medical UniversitySalzburg Cancer Research InstituteParacelsus Medical UniversitySalzburg Cancer Research InstituteCD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of CD44 standard and variant forms and their functional interplay with hyaluronan is less understood in hematological malignancies. Chronic lymphocytic leukemia (CLL) is a highly abundant B cell malignancy with a well coordinated balance between cell cycle-arrest and proliferation of tumor subpopulations. The long-term survival and proliferation of CLL cells requires their dynamic interactions with stromal and immune cells in lymphoid organs. Interactions of HA with CD44 and HA-mediated motility receptor (RHAMM) contribute to CLL cell localization, and hence CLL pathophysiology, by shaping homing, interstitial migration, and adhesion of the tumor cells. CD44 can complex with key prognostic factors of CLL, particularly CD38 and CD49d, bridging the gap between prognosis and cellular function. Here, we review the current evidence for the individual and associated contributions of CD44 to CLL pathophysiology, the dynamic functional regulation of CD44 upon CLL cell activation, and possible therapeutic strategies targeting CD44 in CLL.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00177/fullmicroenvironmentHomingCD44VLA-4chronic lymphocytic leukemiahyaluronan |
| spellingShingle | Julia Christine Gutjahr Julia Christine Gutjahr Richard eGreil Richard eGreil Tanja Nicole Hartmann Tanja Nicole Hartmann The role of CD44 in the pathophysiology of chronic lymphocytic leukemia Frontiers in Immunology microenvironment Homing CD44 VLA-4 chronic lymphocytic leukemia hyaluronan |
| title | The role of CD44 in the pathophysiology of chronic lymphocytic leukemia |
| title_full | The role of CD44 in the pathophysiology of chronic lymphocytic leukemia |
| title_fullStr | The role of CD44 in the pathophysiology of chronic lymphocytic leukemia |
| title_full_unstemmed | The role of CD44 in the pathophysiology of chronic lymphocytic leukemia |
| title_short | The role of CD44 in the pathophysiology of chronic lymphocytic leukemia |
| title_sort | role of cd44 in the pathophysiology of chronic lymphocytic leukemia |
| topic | microenvironment Homing CD44 VLA-4 chronic lymphocytic leukemia hyaluronan |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00177/full |
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