Renal involvement in a silicosis patient – case report and literature review
A 43-year-old Chinese man with a silicosis history was admitted to our hospital due to bilateral lower extremity edema for 1 year, exacerbating with hematuria for 2 months. He started working as a coal miner 30 years ago, and was diagnosed as silicosis 3 months ago. Lab tests revealed hematuria 3+,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2019.1696209 |
| _version_ | 1819100602043465728 |
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| author | Fei-Fei Chen Hai-Yan Tang Feng Yu Cheng-Li Que Fu-de Zhou Su-Xia Wang Guang-Fa Wang Ming-Hui Zhao |
| author_facet | Fei-Fei Chen Hai-Yan Tang Feng Yu Cheng-Li Que Fu-de Zhou Su-Xia Wang Guang-Fa Wang Ming-Hui Zhao |
| author_sort | Fei-Fei Chen |
| collection | DOAJ |
| description | A 43-year-old Chinese man with a silicosis history was admitted to our hospital due to bilateral lower extremity edema for 1 year, exacerbating with hematuria for 2 months. He started working as a coal miner 30 years ago, and was diagnosed as silicosis 3 months ago. Lab tests revealed hematuria 3+, proteinuria 3+, and a serum creatinine value 2.47 mg/dl on routine check. He was diagnosed with focal proliferative IgA nephropathy (IgAN) and acute tubulo-interstitial nephritis by renal biopsy. He was treated with corticosteroids and got a remission 4 months later. Immunohistochemical staining showed the deposition of macrophage receptor with collagenous structure (MARCO), nod-like receptor pyrin domain-containing-3 (NLRP3), Caspase-1, apoptosis-associated speck (ASC), interleukin (IL)-1β, and IL-18 in both glomerular and tubulo-interstitial areas. We proposed that the silicon exposure could be related to his kidney disease in the patient and NLRP3 mediated inflammation might be involved in its pathogenesis which needs further explorations. |
| first_indexed | 2024-12-22T01:05:23Z |
| format | Article |
| id | doaj.art-67bba13aecec4adf8734c0023c417d95 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-22T01:05:23Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-67bba13aecec4adf8734c0023c417d952022-12-21T18:44:06ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492019-01-014111045105310.1080/0886022X.2019.16962091696209Renal involvement in a silicosis patient – case report and literature reviewFei-Fei Chen0Hai-Yan Tang1Feng Yu2Cheng-Li Que3Fu-de Zhou4Su-Xia Wang5Guang-Fa Wang6Ming-Hui Zhao7Peking University First HospitalPeking University First HospitalPeking University First HospitalPeking University First HospitalPeking University First HospitalPeking University First HospitalPeking University First HospitalPeking University First HospitalA 43-year-old Chinese man with a silicosis history was admitted to our hospital due to bilateral lower extremity edema for 1 year, exacerbating with hematuria for 2 months. He started working as a coal miner 30 years ago, and was diagnosed as silicosis 3 months ago. Lab tests revealed hematuria 3+, proteinuria 3+, and a serum creatinine value 2.47 mg/dl on routine check. He was diagnosed with focal proliferative IgA nephropathy (IgAN) and acute tubulo-interstitial nephritis by renal biopsy. He was treated with corticosteroids and got a remission 4 months later. Immunohistochemical staining showed the deposition of macrophage receptor with collagenous structure (MARCO), nod-like receptor pyrin domain-containing-3 (NLRP3), Caspase-1, apoptosis-associated speck (ASC), interleukin (IL)-1β, and IL-18 in both glomerular and tubulo-interstitial areas. We proposed that the silicon exposure could be related to his kidney disease in the patient and NLRP3 mediated inflammation might be involved in its pathogenesis which needs further explorations.http://dx.doi.org/10.1080/0886022X.2019.1696209silicosissilica nephropathyiga nephropathymarco receptorthe nlrp3 inflammasome |
| spellingShingle | Fei-Fei Chen Hai-Yan Tang Feng Yu Cheng-Li Que Fu-de Zhou Su-Xia Wang Guang-Fa Wang Ming-Hui Zhao Renal involvement in a silicosis patient – case report and literature review Renal Failure silicosis silica nephropathy iga nephropathy marco receptor the nlrp3 inflammasome |
| title | Renal involvement in a silicosis patient – case report and literature review |
| title_full | Renal involvement in a silicosis patient – case report and literature review |
| title_fullStr | Renal involvement in a silicosis patient – case report and literature review |
| title_full_unstemmed | Renal involvement in a silicosis patient – case report and literature review |
| title_short | Renal involvement in a silicosis patient – case report and literature review |
| title_sort | renal involvement in a silicosis patient case report and literature review |
| topic | silicosis silica nephropathy iga nephropathy marco receptor the nlrp3 inflammasome |
| url | http://dx.doi.org/10.1080/0886022X.2019.1696209 |
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