Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis
Abstract Background Several studies have linked vascular endothelial growth factors (VEGFs) with metabolic syndrome or its components. However, there has been no systematic appraisal of the findings of these studies to date. The current systematic review and meta-analysis was conducted to explore th...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13098-018-0363-0 |
| _version_ | 1817988171979292672 |
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| author | Mohammad Ishraq Zafar Kerry Mills Xiaofeng Ye Brette Blakely Jie Min Wen Kong Nan Zhang Luoning Gou Anita Regmi Sheng Qing Hu Juan Zheng Lu-Lu Chen |
| author_facet | Mohammad Ishraq Zafar Kerry Mills Xiaofeng Ye Brette Blakely Jie Min Wen Kong Nan Zhang Luoning Gou Anita Regmi Sheng Qing Hu Juan Zheng Lu-Lu Chen |
| author_sort | Mohammad Ishraq Zafar |
| collection | DOAJ |
| description | Abstract Background Several studies have linked vascular endothelial growth factors (VEGFs) with metabolic syndrome or its components. However, there has been no systematic appraisal of the findings of these studies to date. The current systematic review and meta-analysis was conducted to explore this association. Methods PubMed, EMBASE, the Cochrane library, and clinical trials registries were used to retrieve peer-reviewed clinical studies that had evaluated the association of VEGFs with metabolic syndrome or its components without applying language and date restrictions. The final search was performed on 29 September 2017. Results We included 32 studies in this systematic review and meta-analysis, of which 16 studies (19 study arms) were included in the meta-analysis and remaining studies were qualitatively assessed. Overall, VEGF-A, VEGF-B and VEGF-C were strongly associated with metabolic syndrome or its components. The components of metabolic syndrome varied in their association. Obesity was not correlated with increased VEGF-A expression (p = 0.12), whereas VEGF-B and VEGF-C expression was significantly higher in those with obesity. In contrast, hyperglycemia in type 1 diabetes was strongly associated with increased VEGF-A levels (p < 0.00001), as was type 2 diabetes (p = 0.0006). The studies included in the qualitative analysis similarly showed an increase in VEGF family expression in people with metabolic syndrome, and with its components. Conclusion The increased concentrations of vascular endothelial growth factors are variably associated with metabolic syndrome or its components. Each VEGF protein has a unique set of associations with the disease state. |
| first_indexed | 2024-04-14T00:31:01Z |
| format | Article |
| id | doaj.art-67bc3c155feb4387b75e4d01c72af7bf |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-14T00:31:01Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-67bc3c155feb4387b75e4d01c72af7bf2022-12-22T02:22:32ZengBMCDiabetology & Metabolic Syndrome1758-59962018-08-0110111710.1186/s13098-018-0363-0Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysisMohammad Ishraq Zafar0Kerry Mills1Xiaofeng Ye2Brette Blakely3Jie Min4Wen Kong5Nan Zhang6Luoning Gou7Anita Regmi8Sheng Qing Hu9Juan Zheng10Lu-Lu Chen11Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHealth Research Institute, University of CanberraDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCentre for Healthcare Resilience and Implementation Science (CHRIS), Australian Institute of Health Innovation, Macquarie UniversityDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Several studies have linked vascular endothelial growth factors (VEGFs) with metabolic syndrome or its components. However, there has been no systematic appraisal of the findings of these studies to date. The current systematic review and meta-analysis was conducted to explore this association. Methods PubMed, EMBASE, the Cochrane library, and clinical trials registries were used to retrieve peer-reviewed clinical studies that had evaluated the association of VEGFs with metabolic syndrome or its components without applying language and date restrictions. The final search was performed on 29 September 2017. Results We included 32 studies in this systematic review and meta-analysis, of which 16 studies (19 study arms) were included in the meta-analysis and remaining studies were qualitatively assessed. Overall, VEGF-A, VEGF-B and VEGF-C were strongly associated with metabolic syndrome or its components. The components of metabolic syndrome varied in their association. Obesity was not correlated with increased VEGF-A expression (p = 0.12), whereas VEGF-B and VEGF-C expression was significantly higher in those with obesity. In contrast, hyperglycemia in type 1 diabetes was strongly associated with increased VEGF-A levels (p < 0.00001), as was type 2 diabetes (p = 0.0006). The studies included in the qualitative analysis similarly showed an increase in VEGF family expression in people with metabolic syndrome, and with its components. Conclusion The increased concentrations of vascular endothelial growth factors are variably associated with metabolic syndrome or its components. Each VEGF protein has a unique set of associations with the disease state.http://link.springer.com/article/10.1186/s13098-018-0363-0HypertriglyceridemiaHyperglycemiaBody mass indexObesityHypertensionDiabetes |
| spellingShingle | Mohammad Ishraq Zafar Kerry Mills Xiaofeng Ye Brette Blakely Jie Min Wen Kong Nan Zhang Luoning Gou Anita Regmi Sheng Qing Hu Juan Zheng Lu-Lu Chen Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis Diabetology & Metabolic Syndrome Hypertriglyceridemia Hyperglycemia Body mass index Obesity Hypertension Diabetes |
| title | Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis |
| title_full | Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis |
| title_fullStr | Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis |
| title_full_unstemmed | Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis |
| title_short | Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis |
| title_sort | association between the expression of vascular endothelial growth factors and metabolic syndrome or its components a systematic review and meta analysis |
| topic | Hypertriglyceridemia Hyperglycemia Body mass index Obesity Hypertension Diabetes |
| url | http://link.springer.com/article/10.1186/s13098-018-0363-0 |
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