In Silico and In Vitro Assessment of Antimicrobial and Antibiofilm Activity of Some 1,3-Oxazole-Based Compounds and Their Isosteric Analogues

In Silico and In Vitro Assessment of Antimicrobial and Antibiofilm Activity of Some 1,3-Oxazole-Based Compounds and Their Isosteric Analogues

In this paper, we report on the antimicrobial activity assessment of 49 compounds previously synthesized as derivatives of alanine or phenylalanine that incorporate a 4-(4-X-phenylsulfonyl)phenyl fragment (X = H, Cl, or Br), namely 21 acyclic compounds (6 × <i>N</i>-acyl-α-amino acids, 1...

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Bibliographic Details
Main Authors: Theodora-Venera Apostol, Mariana Carmen Chifiriuc, George Mihai Nitulescu, Octavian Tudorel Olaru, Stefania-Felicia Barbuceanu, Laura-Ileana Socea, Elena Mihaela Pahontu, Crina Maria Karmezan, Luminita Gabriela Marutescu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Applied Sciences
Subjects:
antimicrobial
antibiofilm
<i>N</i>-acyl-α-amino acid
4<i>H</i>-1,3-oxazol-5-one
<i>N</i>-acyl-α-amino acid ester
<i>N</i>-acyl-α-amino ketone
Online Access:https://www.mdpi.com/2076-3417/12/11/5571

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