Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional Study
Background: Primary lactose intolerance (PLI) is characterized by the inability to digest lactose. Homozygotes for the lactase gene polymorphisms (CC or GG) are considered to be genetically predisposed to PLI. Still, symptoms may only be present later in life. The evidence supporting a link between...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/6/1075 |
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| author | Corina Pienar Liviu Pop Marilena Lăzărescu Radmila Costăchescu Mirela Mogoi Ruxandra Mare Edward Șeclăman |
| author_facet | Corina Pienar Liviu Pop Marilena Lăzărescu Radmila Costăchescu Mirela Mogoi Ruxandra Mare Edward Șeclăman |
| author_sort | Corina Pienar |
| collection | DOAJ |
| description | Background: Primary lactose intolerance (PLI) is characterized by the inability to digest lactose. Homozygotes for the lactase gene polymorphisms (CC or GG) are considered to be genetically predisposed to PLI. Still, symptoms may only be present later in life. The evidence supporting a link between PLI, dairy intake, and quality of life (QoL) is limited in children. Aim: This study investigates the link between LCT polymorphisms and suggestive symptoms and the influence of the genetic predisposition to PLI on dairy intake and QoL in Romanian children. Materials and methods: We recruited consecutive children evaluated in our ambulatory clinic. We asked all participants to complete a visual-analog symptoms scale, a dairy intake, and a QoL questionnaire. We used strip genotyping to identify genetic predisposition to PLI. Results: 51.7% of children had a CC genotype, and 34.5% also had a GG genotype. Most children reported no or mild symptoms. Dairy intake and QoL were similar across study groups. Conclusions: Our study shows that genetic predisposition does not necessarily assume the presence of specific symptoms. Genetic predisposition to PLI did not lead to dairy avoidance, nor did it negatively influence our children’s QoL. |
| first_indexed | 2024-03-11T02:36:48Z |
| format | Article |
| id | doaj.art-67bc7c72a3254228b90a9a51fb838acf |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T02:36:48Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-67bc7c72a3254228b90a9a51fb838acf2023-11-18T09:51:14ZengMDPI AGChildren2227-90672023-06-01106107510.3390/children10061075Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional StudyCorina Pienar0Liviu Pop1Marilena Lăzărescu2Radmila Costăchescu3Mirela Mogoi4Ruxandra Mare5Edward Șeclăman6Department of Pediatrics, 2nd Pediatrics Clinic, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Pediatrics, 2nd Pediatrics Clinic, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaThe Necker-Enfants Malades Hospital, University of Paris Descartes, 75006 Paris, FranceDepartment of Pediatrics, 2nd Pediatrics Clinic, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Pediatrics, 2nd Pediatrics Clinic, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaGastroenterology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaBiochemistry Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaBackground: Primary lactose intolerance (PLI) is characterized by the inability to digest lactose. Homozygotes for the lactase gene polymorphisms (CC or GG) are considered to be genetically predisposed to PLI. Still, symptoms may only be present later in life. The evidence supporting a link between PLI, dairy intake, and quality of life (QoL) is limited in children. Aim: This study investigates the link between LCT polymorphisms and suggestive symptoms and the influence of the genetic predisposition to PLI on dairy intake and QoL in Romanian children. Materials and methods: We recruited consecutive children evaluated in our ambulatory clinic. We asked all participants to complete a visual-analog symptoms scale, a dairy intake, and a QoL questionnaire. We used strip genotyping to identify genetic predisposition to PLI. Results: 51.7% of children had a CC genotype, and 34.5% also had a GG genotype. Most children reported no or mild symptoms. Dairy intake and QoL were similar across study groups. Conclusions: Our study shows that genetic predisposition does not necessarily assume the presence of specific symptoms. Genetic predisposition to PLI did not lead to dairy avoidance, nor did it negatively influence our children’s QoL.https://www.mdpi.com/2227-9067/10/6/1075lactose intolerancepolymorphismsdairy intakequality of lifechildren |
| spellingShingle | Corina Pienar Liviu Pop Marilena Lăzărescu Radmila Costăchescu Mirela Mogoi Ruxandra Mare Edward Șeclăman Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional Study Children lactose intolerance polymorphisms dairy intake quality of life children |
| title | Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional Study |
| title_full | Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional Study |
| title_fullStr | Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional Study |
| title_full_unstemmed | Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional Study |
| title_short | Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional Study |
| title_sort | genetic predisposition to primary lactose intolerance does not influence dairy intake and health related quality of life in romanian children a hospital based cross sectional study |
| topic | lactose intolerance polymorphisms dairy intake quality of life children |
| url | https://www.mdpi.com/2227-9067/10/6/1075 |
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