Intra-host Trypanosoma cruzi strain dynamics shape disease progression: the missing link in Chagas disease pathogenesis

Intra-host Trypanosoma cruzi strain dynamics shape disease progression: the missing link in Chagas disease pathogenesis

ABSTRACT Chronic Chagasic cardiomyopathy develops years after infection in 20–40% of patients, but disease progression is poorly understood. Here, we assessed Trypanosoma cruzi parasite dynamics and pathogenesis over a 2.5-year period in naturally infected rhesus macaques. Individuals with better co...

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Bibliographic Details
Main Authors: Eric Dumonteil, Hans Desale, Weihong Tu, Nora Hernandez-Cuevas, Monica Shroyer, Kelly Goff, Preston A. Marx, Claudia Herrera
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
strain interactions
host-parasite relationship
intracellular parasites
competition
pathogenesis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04236-22

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