Features of the Drug Therapy of Children with Systemic Juvenile Idiopathic Arthritis: Analysis Results of the All-Russian Register of the Union of Pediatricians of Russia
Objective: Our aim was to study features of the drug therapy of children with systemic juvenile idiopathic arthritis (sJIA).Methods: We conducted a retrospective data analysis included in the Register of sJIA cases, for the period from 2002 to 2015.Results: The indicators of 384 children with sJIA a...
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"Paediatrician" Publishers LLC
2016-02-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1582 |
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| author | E. I. Alexeeva O. L. Lomakina S. I. Valieva T. M. Bzarova I. P. Nikishina Ye. S. Zholobova G. G. Torosyan S. R. Rodionovskaya M. I. Kaleda L. A. Galstyan I. B. Alakaeva Ye. A. Korotkova A. V. Artyomov D. Yu. Vurdov |
| author_facet | E. I. Alexeeva O. L. Lomakina S. I. Valieva T. M. Bzarova I. P. Nikishina Ye. S. Zholobova G. G. Torosyan S. R. Rodionovskaya M. I. Kaleda L. A. Galstyan I. B. Alakaeva Ye. A. Korotkova A. V. Artyomov D. Yu. Vurdov |
| author_sort | E. I. Alexeeva |
| collection | DOAJ |
| description | Objective: Our aim was to study features of the drug therapy of children with systemic juvenile idiopathic arthritis (sJIA).Methods: We conducted a retrospective data analysis included in the Register of sJIA cases, for the period from 2002 to 2015.Results: The indicators of 384 children with sJIA are studied. Prior to the diagnosis verification, all patients were prescribed to intake antipyretic agents, 98% — antibiotics. After the diagnosis, non-steroidal anti-inflammatory drugs (NSAIDs) were intaken by 282 (73.4%) patients: diclofenac sodium — by 163 (40.1%), nimesulide — by 88 (22.9%) patients. The average duration of NSAID intake from 2002 to 2015 decreased from 81.5 ± 115.3 to 3.3 ± 3.7 months (p < 0.001). Prior to the diagnosis verification, glucocorticoids were received intravenously or intramuscularly by 265 (69.0%) patients, orally — 176 (45.8%). Totally, glucocorticoids were received by 330 (85.9%) patients: methylprednisolone — 300 of 384 (78.1%), prednisolone — 174 (45.3%), there were totally 1855 prescriptions in 668 patients. The average duration of glucocorticoid intake from 2002 to 2015 decreased from 13.7 ± 26.7 to 5.0 ± 3,8 months (p < 0.001). As a disease-modifying drug, methotrexate was intaken by 237 (61.7%), Cyclosporin — by 193 (50.6%) patients. There were totally 809 prescriptions of genetically engineered biological preparations (GIBP) in 430 patients: in 2002–2005–8, in 2011–2015–602 in 397 patients (p = 0.001). Tocilizumab is intaken by 210 (52.9%) of 397 patients, kanakinumab — 37 (9.3%) patients. The disease duration from the manifestation to the prescription of immunosuppressive drugs from 2002 to 2015 decreased from 27.3 ± 23.9 to 1.0 ± 0 months (p < 0.001), GIBP prescriptions — from 70.7 ± 26.3 to 0.5 ± 0.7 months, respectively (p < 0.001).Conclusion: In 13 years there have been positive changes in the antirheumatic therapy in children with sJIA — the duration of NSAIDs and glucocorticoids intake reduced, the period between diagnosis verification and immunosuppressants and GIBP prescription decreased. However, it is still widely used antibiotics, non-selective NSAIDs and glucocorticoids. |
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| series | Вопросы современной педиатрии |
| spelling | doaj.art-67bcf7042e6b417495df2e3378eb2a0c2023-09-03T10:32:29Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352016-02-01151596710.15690/vsp.v15i1.15001564Features of the Drug Therapy of Children with Systemic Juvenile Idiopathic Arthritis: Analysis Results of the All-Russian Register of the Union of Pediatricians of RussiaE. I. Alexeeva0O. L. Lomakina1S. I. Valieva2T. M. Bzarova3I. P. Nikishina4Ye. S. Zholobova5G. G. Torosyan6S. R. Rodionovskaya7M. I. Kaleda8L. A. Galstyan9I. B. Alakaeva10Ye. A. Korotkova11A. V. Artyomov12D. Yu. Vurdov13Научный центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. СеченоваНаучный центр здоровья детейНаучный центр здоровья детей; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаНаучный центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. СеченоваНИИ ревматологии им. В.А. НасоновойПервый Московский государственный медицинский университет им. И.М. Сеченова; Морозовская детская городская клиническая больницаПервый Московский государственный медицинский университет им. И.М. СеченоваНИИ ревматологии им. В.А. Насоновой; Детская клиническая больница ФМБА № 38НИИ ревматологии им. В.А. НасоновойПервый Московский государственный медицинский университет им. И.М. СеченоваДетская клиническая больница ФМБА № 38Первый Московский государственный медицинский университет им. И.М. СеченоваЗАО «Астон Консалтинг»ЗАО «Астон Консалтинг»Objective: Our aim was to study features of the drug therapy of children with systemic juvenile idiopathic arthritis (sJIA).Methods: We conducted a retrospective data analysis included in the Register of sJIA cases, for the period from 2002 to 2015.Results: The indicators of 384 children with sJIA are studied. Prior to the diagnosis verification, all patients were prescribed to intake antipyretic agents, 98% — antibiotics. After the diagnosis, non-steroidal anti-inflammatory drugs (NSAIDs) were intaken by 282 (73.4%) patients: diclofenac sodium — by 163 (40.1%), nimesulide — by 88 (22.9%) patients. The average duration of NSAID intake from 2002 to 2015 decreased from 81.5 ± 115.3 to 3.3 ± 3.7 months (p < 0.001). Prior to the diagnosis verification, glucocorticoids were received intravenously or intramuscularly by 265 (69.0%) patients, orally — 176 (45.8%). Totally, glucocorticoids were received by 330 (85.9%) patients: methylprednisolone — 300 of 384 (78.1%), prednisolone — 174 (45.3%), there were totally 1855 prescriptions in 668 patients. The average duration of glucocorticoid intake from 2002 to 2015 decreased from 13.7 ± 26.7 to 5.0 ± 3,8 months (p < 0.001). As a disease-modifying drug, methotrexate was intaken by 237 (61.7%), Cyclosporin — by 193 (50.6%) patients. There were totally 809 prescriptions of genetically engineered biological preparations (GIBP) in 430 patients: in 2002–2005–8, in 2011–2015–602 in 397 patients (p = 0.001). Tocilizumab is intaken by 210 (52.9%) of 397 patients, kanakinumab — 37 (9.3%) patients. The disease duration from the manifestation to the prescription of immunosuppressive drugs from 2002 to 2015 decreased from 27.3 ± 23.9 to 1.0 ± 0 months (p < 0.001), GIBP prescriptions — from 70.7 ± 26.3 to 0.5 ± 0.7 months, respectively (p < 0.001).Conclusion: In 13 years there have been positive changes in the antirheumatic therapy in children with sJIA — the duration of NSAIDs and glucocorticoids intake reduced, the period between diagnosis verification and immunosuppressants and GIBP prescription decreased. However, it is still widely used antibiotics, non-selective NSAIDs and glucocorticoids.https://vsp.spr-journal.ru/jour/article/view/1582детирегистрюношеский артрит с системный началомпротиворевматическая терапиягенно-инженерные биологические препараты |
| spellingShingle | E. I. Alexeeva O. L. Lomakina S. I. Valieva T. M. Bzarova I. P. Nikishina Ye. S. Zholobova G. G. Torosyan S. R. Rodionovskaya M. I. Kaleda L. A. Galstyan I. B. Alakaeva Ye. A. Korotkova A. V. Artyomov D. Yu. Vurdov Features of the Drug Therapy of Children with Systemic Juvenile Idiopathic Arthritis: Analysis Results of the All-Russian Register of the Union of Pediatricians of Russia Вопросы современной педиатрии дети регистр юношеский артрит с системный началом противоревматическая терапия генно-инженерные биологические препараты |
| title | Features of the Drug Therapy of Children with Systemic Juvenile Idiopathic Arthritis: Analysis Results of the All-Russian Register of the Union of Pediatricians of Russia |
| title_full | Features of the Drug Therapy of Children with Systemic Juvenile Idiopathic Arthritis: Analysis Results of the All-Russian Register of the Union of Pediatricians of Russia |
| title_fullStr | Features of the Drug Therapy of Children with Systemic Juvenile Idiopathic Arthritis: Analysis Results of the All-Russian Register of the Union of Pediatricians of Russia |
| title_full_unstemmed | Features of the Drug Therapy of Children with Systemic Juvenile Idiopathic Arthritis: Analysis Results of the All-Russian Register of the Union of Pediatricians of Russia |
| title_short | Features of the Drug Therapy of Children with Systemic Juvenile Idiopathic Arthritis: Analysis Results of the All-Russian Register of the Union of Pediatricians of Russia |
| title_sort | features of the drug therapy of children with systemic juvenile idiopathic arthritis analysis results of the all russian register of the union of pediatricians of russia |
| topic | дети регистр юношеский артрит с системный началом противоревматическая терапия генно-инженерные биологические препараты |
| url | https://vsp.spr-journal.ru/jour/article/view/1582 |
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