Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction
Mitochondrial and endoplasmic reticulum (ER) are important intracellular organelles. The sites that mitochondrial and ER are closely related in structure and function are called Mitochondria-ER contacts (MERCs). MERCs are involved in a variety of biological processes, including calcium signaling, li...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1036225/full |
| _version_ | 1811216852808892416 |
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| author | Tao Jiang Tao Jiang Qian Wang Jiagao Lv Li Lin |
| author_facet | Tao Jiang Tao Jiang Qian Wang Jiagao Lv Li Lin |
| author_sort | Tao Jiang |
| collection | DOAJ |
| description | Mitochondrial and endoplasmic reticulum (ER) are important intracellular organelles. The sites that mitochondrial and ER are closely related in structure and function are called Mitochondria-ER contacts (MERCs). MERCs are involved in a variety of biological processes, including calcium signaling, lipid synthesis and transport, autophagy, mitochondrial dynamics, ER stress, and inflammation. Sepsis-induced myocardial dysfunction (SIMD) is a vital organ damage caused by sepsis, which is closely associated with mitochondrial and ER dysfunction. Growing evidence strongly supports the role of MERCs in the pathogenesis of SIMD. In this review, we summarize the biological functions of MERCs and the roles of MERCs proteins in SIMD. |
| first_indexed | 2024-04-12T06:45:56Z |
| format | Article |
| id | doaj.art-67bdd8cc12f74686a3789ac1bd1e4cc5 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T06:45:56Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-67bdd8cc12f74686a3789ac1bd1e4cc52022-12-22T03:43:34ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-11-011010.3389/fcell.2022.10362251036225Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunctionTao Jiang0Tao Jiang1Qian Wang2Jiagao Lv3Li Lin4Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaMitochondrial and endoplasmic reticulum (ER) are important intracellular organelles. The sites that mitochondrial and ER are closely related in structure and function are called Mitochondria-ER contacts (MERCs). MERCs are involved in a variety of biological processes, including calcium signaling, lipid synthesis and transport, autophagy, mitochondrial dynamics, ER stress, and inflammation. Sepsis-induced myocardial dysfunction (SIMD) is a vital organ damage caused by sepsis, which is closely associated with mitochondrial and ER dysfunction. Growing evidence strongly supports the role of MERCs in the pathogenesis of SIMD. In this review, we summarize the biological functions of MERCs and the roles of MERCs proteins in SIMD.https://www.frontiersin.org/articles/10.3389/fcell.2022.1036225/fullsepsis-induced myocardial dysfunctioncalcium signalingautophagymitochondrial dynamicsER stressmitochondria-ER contacts |
| spellingShingle | Tao Jiang Tao Jiang Qian Wang Jiagao Lv Li Lin Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction Frontiers in Cell and Developmental Biology sepsis-induced myocardial dysfunction calcium signaling autophagy mitochondrial dynamics ER stress mitochondria-ER contacts |
| title | Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction |
| title_full | Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction |
| title_fullStr | Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction |
| title_full_unstemmed | Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction |
| title_short | Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction |
| title_sort | mitochondria endoplasmic reticulum contacts in sepsis induced myocardial dysfunction |
| topic | sepsis-induced myocardial dysfunction calcium signaling autophagy mitochondrial dynamics ER stress mitochondria-ER contacts |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1036225/full |
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