Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array

We present an alternative post-processing on a CMOS chip to release a planar microelectrode array (pMEA) integrated with its signal readout circuit, which can be used for monitoring the neuronal activity of vestibular ganglion neurons in newborn Wistar strain rats. This chip is fabricated through a...

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Main Authors: Blanca Cervantes-Sanchez, Blanca S. Soto-Cruz, Enrique Soto, Carlos Zuñiga-Islas, Johan J. Estrada-López, Francisco López-Huerta, Agustín L. Herrera-May
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:Sensors
Subjects:
Online Access:http://www.mdpi.com/1424-8220/11/11/10940/
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author Blanca Cervantes-Sanchez
Blanca S. Soto-Cruz
Enrique Soto
Carlos Zuñiga-Islas
Johan J. Estrada-López
Francisco López-Huerta
Agustín L. Herrera-May
author_facet Blanca Cervantes-Sanchez
Blanca S. Soto-Cruz
Enrique Soto
Carlos Zuñiga-Islas
Johan J. Estrada-López
Francisco López-Huerta
Agustín L. Herrera-May
author_sort Blanca Cervantes-Sanchez
collection DOAJ
description We present an alternative post-processing on a CMOS chip to release a planar microelectrode array (pMEA) integrated with its signal readout circuit, which can be used for monitoring the neuronal activity of vestibular ganglion neurons in newborn Wistar strain rats. This chip is fabricated through a 0.6 µm CMOS standard process and it has 12 pMEA through a 4  ´ 3 electrodes matrix. The alternative CMOS post-process includes the development of masks to protect the readout circuit and the power supply pads. A wet etching process eliminates the aluminum located on the surface of the p+-type silicon. This silicon is used as transducer for recording the neuronal activity and as interface between the readout circuit and neurons. The readout circuit is composed of an amplifier and tunable bandpass filter, which is placed on a 0.015 mm2 silicon area. The tunable bandpass filter has a bandwidth of 98 kHz and a common mode rejection ratio (CMRR) of 87 dB. These characteristics of the readout circuit are appropriate for neuronal recording applications.
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spelling doaj.art-67c0dfaf26a247a6b9693c3e865b78b82022-12-22T04:01:24ZengMDPI AGSensors1424-82202011-11-011111109401095710.3390/s111110940Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode ArrayBlanca Cervantes-SanchezBlanca S. Soto-CruzEnrique SotoCarlos Zuñiga-IslasJohan J. Estrada-LópezFrancisco López-HuertaAgustín L. Herrera-MayWe present an alternative post-processing on a CMOS chip to release a planar microelectrode array (pMEA) integrated with its signal readout circuit, which can be used for monitoring the neuronal activity of vestibular ganglion neurons in newborn Wistar strain rats. This chip is fabricated through a 0.6 µm CMOS standard process and it has 12 pMEA through a 4  ´ 3 electrodes matrix. The alternative CMOS post-process includes the development of masks to protect the readout circuit and the power supply pads. A wet etching process eliminates the aluminum located on the surface of the p+-type silicon. This silicon is used as transducer for recording the neuronal activity and as interface between the readout circuit and neurons. The readout circuit is composed of an amplifier and tunable bandpass filter, which is placed on a 0.015 mm2 silicon area. The tunable bandpass filter has a bandwidth of 98 kHz and a common mode rejection ratio (CMRR) of 87 dB. These characteristics of the readout circuit are appropriate for neuronal recording applications.http://www.mdpi.com/1424-8220/11/11/10940/CMOS chipmicroelectrode arrayCMOS post-processvestibular ganglion neurons
spellingShingle Blanca Cervantes-Sanchez
Blanca S. Soto-Cruz
Enrique Soto
Carlos Zuñiga-Islas
Johan J. Estrada-López
Francisco López-Huerta
Agustín L. Herrera-May
Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
Sensors
CMOS chip
microelectrode array
CMOS post-process
vestibular ganglion neurons
title Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_full Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_fullStr Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_full_unstemmed Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_short Alternative Post-Processing on a CMOS Chip to Fabricate a Planar Microelectrode Array
title_sort alternative post processing on a cmos chip to fabricate a planar microelectrode array
topic CMOS chip
microelectrode array
CMOS post-process
vestibular ganglion neurons
url http://www.mdpi.com/1424-8220/11/11/10940/
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