Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer
The main goal of this study was to characterize cancer/testis antigens (CTAs) as potential molecular markers of ovarian cancer. First, we gathered and analyzed a significantly large dataset of 21 selected CTAs that are encoded by 32 genes; the dataset consisted of the mutation data, expression data,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/19/3092 |
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| author | Ramilia Vlasenkova Daliya Konysheva Alsina Nurgalieva Ramziya Kiyamova |
| author_facet | Ramilia Vlasenkova Daliya Konysheva Alsina Nurgalieva Ramziya Kiyamova |
| author_sort | Ramilia Vlasenkova |
| collection | DOAJ |
| description | The main goal of this study was to characterize cancer/testis antigens (CTAs) as potential molecular markers of ovarian cancer. First, we gathered and analyzed a significantly large dataset of 21 selected CTAs that are encoded by 32 genes; the dataset consisted of the mutation data, expression data, and survival data of patients with ovarian cancer (n = 15,665). The 19 functionally significant missense mutations were identified in 9 CTA genes: ACRBP, CCT4, KDM5B, MAGEA1, MAGEA4, PIWIL1, PIWIL2, PRAME, and SPA17. The analysis of the mRNA expression levels of 21 CTAs in healthy and tumor ovarian tissue showed an up-regulation in the expression level of AKAP3, MAGEA4, PIWIL1, and PRAME in tumor samples and a down-regulation in the expression level of CTAG1A, CTAG1B, MAGEC1, and PIWIL2. The CCT4 up-regulation and PRAME mutations were correlated with a good prognosis for ovarian cancer, while higher levels of GAGE2A and CT45A1 mRNAs were correlated with a poor prognosis for ovarian cancer patients. Thus, GAGE2, CT45, CCT4, and PRAME cancer/testis antigens can be considered as potential prognostic markers for ovarian tumors, and GAGE2, CCT4, and PRAME were revealed to be correlated with the prognosis for ovarian cancer patients for the first time. |
| first_indexed | 2024-03-10T21:46:38Z |
| format | Article |
| id | doaj.art-67c26db31c194425ae1d453b5f6dcb8e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T21:46:38Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-67c26db31c194425ae1d453b5f6dcb8e2023-11-19T14:14:38ZengMDPI AGDiagnostics2075-44182023-09-011319309210.3390/diagnostics13193092Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian CancerRamilia Vlasenkova0Daliya Konysheva1Alsina Nurgalieva2Ramziya Kiyamova3Biomarker Research Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, RussiaBiomarker Research Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, RussiaBiomarker Research Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, RussiaBiomarker Research Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, RussiaThe main goal of this study was to characterize cancer/testis antigens (CTAs) as potential molecular markers of ovarian cancer. First, we gathered and analyzed a significantly large dataset of 21 selected CTAs that are encoded by 32 genes; the dataset consisted of the mutation data, expression data, and survival data of patients with ovarian cancer (n = 15,665). The 19 functionally significant missense mutations were identified in 9 CTA genes: ACRBP, CCT4, KDM5B, MAGEA1, MAGEA4, PIWIL1, PIWIL2, PRAME, and SPA17. The analysis of the mRNA expression levels of 21 CTAs in healthy and tumor ovarian tissue showed an up-regulation in the expression level of AKAP3, MAGEA4, PIWIL1, and PRAME in tumor samples and a down-regulation in the expression level of CTAG1A, CTAG1B, MAGEC1, and PIWIL2. The CCT4 up-regulation and PRAME mutations were correlated with a good prognosis for ovarian cancer, while higher levels of GAGE2A and CT45A1 mRNAs were correlated with a poor prognosis for ovarian cancer patients. Thus, GAGE2, CT45, CCT4, and PRAME cancer/testis antigens can be considered as potential prognostic markers for ovarian tumors, and GAGE2, CCT4, and PRAME were revealed to be correlated with the prognosis for ovarian cancer patients for the first time.https://www.mdpi.com/2075-4418/13/19/3092cancer-testis antigensCTAovarian cancer |
| spellingShingle | Ramilia Vlasenkova Daliya Konysheva Alsina Nurgalieva Ramziya Kiyamova Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer Diagnostics cancer-testis antigens CTA ovarian cancer |
| title | Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer |
| title_full | Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer |
| title_fullStr | Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer |
| title_full_unstemmed | Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer |
| title_short | Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer |
| title_sort | characterization of cancer testis antigens as prognostic markers of ovarian cancer |
| topic | cancer-testis antigens CTA ovarian cancer |
| url | https://www.mdpi.com/2075-4418/13/19/3092 |
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