24-hydroxycholesterol moderates the effects of amyloid-β on expression of HMG-CoA reductase and ABCA1 proteins in mouse astrocytes

24-hydroxycholesterol moderates the effects of amyloid-β on expression of HMG-CoA reductase and ABCA1 proteins in mouse astrocytes

Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA reductase and ABCA1 which are involved i...

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Bibliographic Details
Main Authors: Zahra Nazeri, Ghorban Mohammadzadeh, Mojtaba Rashidi, Shirin Azizdoost, Maryam Cheraghzadeh, Alireza Kheirollah
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Advanced Biomedical Research
Subjects:
abca1
amyloid beta-peptides
brain
cholesterol
hydroxycholesterols
hmg-coa
Online Access:http://www.advbiores.net/article.asp?issn=2277-9175;year=2023;volume=12;issue=1;spage=167;epage=167;aulast=Nazeri

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