Enhanced Corneal Penetration of a Poorly Permeable Drug Using Bioadhesive Multiple Microemulsion Technology

Enhanced Corneal Penetration of a Poorly Permeable Drug Using Bioadhesive Multiple Microemulsion Technology

Corneal penetration is a key rate limiting step in the bioavailability of topical ophthalmic formulations that incorporate poorly permeable drugs. Recent advances have greatly aided the ocular delivery of such drugs using colloidal drug delivery systems. Ribavirin, a poorly permeable BCS class-III d...

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Bibliographic Details
Main Authors: Mohamed Moustafa Ibrahim, Doaa Nabih Maria, XiangDi Wang, Raven N. Simpson, T.J. Hollingsworth, Monica M. Jablonski
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
microemulsion
corneal permeability
cytotoxicity
freeze–thaw
modified Draize test
ocular tolerance
Online Access:https://www.mdpi.com/1999-4923/12/8/704

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