HIV-1-related factors interact with p53 to influence cellular processes
Abstract Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate inte...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
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| Series: | AIDS Research and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12981-023-00563-7 |
| _version_ | 1797556297181167616 |
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| author | Shanling Liu Ting Guo Jinwei Hu Weiliang Huang Pengfei She Yong Wu |
| author_facet | Shanling Liu Ting Guo Jinwei Hu Weiliang Huang Pengfei She Yong Wu |
| author_sort | Shanling Liu |
| collection | DOAJ |
| description | Abstract Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also control viral pathogenesis. For example, HIV-1 regulates the life cycle of p53, which in turn contributes significantly to HIV-1 pathogenesis. In this article, we review the interaction between HIV-1-associated factors and p53, providing information on their regulatory and molecular mechanisms, hinting possible directions for further research. |
| first_indexed | 2024-03-10T17:00:48Z |
| format | Article |
| id | doaj.art-67c58ee221474c55b215322c164c775d |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-03-10T17:00:48Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-67c58ee221474c55b215322c164c775d2023-11-20T10:59:01ZengBMCAIDS Research and Therapy1742-64052023-09-012011910.1186/s12981-023-00563-7HIV-1-related factors interact with p53 to influence cellular processesShanling Liu0Ting Guo1Jinwei Hu2Weiliang Huang3Pengfei She4Yong Wu5Department of Laboratory Medicine, The First Hospital of ChangshaDepartment of Laboratory Medicine, The First Hospital of ChangshaDepartment of Laboratory Medicine, The First Hospital of ChangshaDepartment of Laboratory Medicine, The First Hospital of ChangshaDepartment of Laboratory Medicine, Third Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The First Hospital of ChangshaAbstract Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also control viral pathogenesis. For example, HIV-1 regulates the life cycle of p53, which in turn contributes significantly to HIV-1 pathogenesis. In this article, we review the interaction between HIV-1-associated factors and p53, providing information on their regulatory and molecular mechanisms, hinting possible directions for further research.https://doi.org/10.1186/s12981-023-00563-7HIV-1p53RegulationMolecular mechanism |
| spellingShingle | Shanling Liu Ting Guo Jinwei Hu Weiliang Huang Pengfei She Yong Wu HIV-1-related factors interact with p53 to influence cellular processes AIDS Research and Therapy HIV-1 p53 Regulation Molecular mechanism |
| title | HIV-1-related factors interact with p53 to influence cellular processes |
| title_full | HIV-1-related factors interact with p53 to influence cellular processes |
| title_fullStr | HIV-1-related factors interact with p53 to influence cellular processes |
| title_full_unstemmed | HIV-1-related factors interact with p53 to influence cellular processes |
| title_short | HIV-1-related factors interact with p53 to influence cellular processes |
| title_sort | hiv 1 related factors interact with p53 to influence cellular processes |
| topic | HIV-1 p53 Regulation Molecular mechanism |
| url | https://doi.org/10.1186/s12981-023-00563-7 |
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