Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications
Magnetic nanoparticles are highly promising for the usage in various biomedical applications including magnetic particle imaging (MPI), cancer hyperthermia treatment or as drug carriers. The present study aims at assessing in vitro biocompatibility of two commercially available magnetic iron oxide n...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2019-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2019-0144 |
| _version_ | 1828912148964704256 |
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| author | Matschegewski Claudia Kowalski Anja Müller Knut Teller Henrik Grabow Niels Großmann Swen Schmitz Klaus-Peter Siewert Stefan |
| author_facet | Matschegewski Claudia Kowalski Anja Müller Knut Teller Henrik Grabow Niels Großmann Swen Schmitz Klaus-Peter Siewert Stefan |
| author_sort | Matschegewski Claudia |
| collection | DOAJ |
| description | Magnetic nanoparticles are highly promising for the usage in various biomedical applications including magnetic particle imaging (MPI), cancer hyperthermia treatment or as drug carriers. The present study aims at assessing in vitro biocompatibility of two commercially available magnetic iron oxide nanoparticle formulations: dextran-based magnetic nanoparticle synomag-D and bionized nanoferrite BNF-starch. Biological performance of both nanoparticle formulations were studied in human endothelial cells by analyzing cell viability and nanoparticle internalization in order to judge their suitability as theranostics. |
| first_indexed | 2024-12-13T19:14:37Z |
| format | Article |
| id | doaj.art-67c5cd27e18d4dd19533eb7303730933 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-12-13T19:14:37Z |
| publishDate | 2019-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-67c5cd27e18d4dd19533eb73037309332022-12-21T23:34:18ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042019-09-015157357610.1515/cdbme-2019-0144cdbme-2019-0144Biocompatibility of magnetic iron oxide nanoparticles for biomedical applicationsMatschegewski Claudia0Kowalski Anja1Müller Knut2Teller Henrik3Grabow Niels4Großmann Swen5Schmitz Klaus-Peter6Siewert Stefan7Institute for ImplantTechnology and Biomaterials (IIB) e.V., Friedrich- Barnewitz-Straße 4,Rostock, Germanymicromod Partikeltechnologie GmbH,Rostock, Germanymicromod Partikeltechnologie GmbH,Rostock, Germanymicromod Partikeltechnologie GmbH,Rostock, GermanyInstitute of Biomedical Engineering,Rostock, GermanyInstitute for ImplantTechnology and Biomaterials (IIB) e.V.,Rostock, GermanyInstitute for ImplantTechnology and Biomaterials (IIB) e.V.,Rostock, GermanyInstitute for ImplantTechnology and Biomaterials (IIB) e.V.,Rostock, GermanyMagnetic nanoparticles are highly promising for the usage in various biomedical applications including magnetic particle imaging (MPI), cancer hyperthermia treatment or as drug carriers. The present study aims at assessing in vitro biocompatibility of two commercially available magnetic iron oxide nanoparticle formulations: dextran-based magnetic nanoparticle synomag-D and bionized nanoferrite BNF-starch. Biological performance of both nanoparticle formulations were studied in human endothelial cells by analyzing cell viability and nanoparticle internalization in order to judge their suitability as theranostics.https://doi.org/10.1515/cdbme-2019-0144magnetic nanoparticlemagnetic particle imaginghuman endothelial cellsbiocompatibilityinternalizationcellular uptake |
| spellingShingle | Matschegewski Claudia Kowalski Anja Müller Knut Teller Henrik Grabow Niels Großmann Swen Schmitz Klaus-Peter Siewert Stefan Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications Current Directions in Biomedical Engineering magnetic nanoparticle magnetic particle imaging human endothelial cells biocompatibility internalization cellular uptake |
| title | Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications |
| title_full | Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications |
| title_fullStr | Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications |
| title_full_unstemmed | Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications |
| title_short | Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications |
| title_sort | biocompatibility of magnetic iron oxide nanoparticles for biomedical applications |
| topic | magnetic nanoparticle magnetic particle imaging human endothelial cells biocompatibility internalization cellular uptake |
| url | https://doi.org/10.1515/cdbme-2019-0144 |
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