Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver Transplantation
<i>Background and Objectives</i>: Development of hepatitis-B is considered a serious complication after liver transplantation. HBV de novo infection is a rather rare phenomenon, however it deserves attention in the era of donor organ shortage. The aim of the present analysis was to exami...
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MDPI AG
2021-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/8/767 |
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| author | Ramin Raul Ossami Saidy Franziska Eurich Maximilian Paul Postel Eva Maria Dobrindt Jasper Feldkamp Selina Johanna Schaper Johann Pratschke Brigitta Globke Dennis Eurich |
| author_facet | Ramin Raul Ossami Saidy Franziska Eurich Maximilian Paul Postel Eva Maria Dobrindt Jasper Feldkamp Selina Johanna Schaper Johann Pratschke Brigitta Globke Dennis Eurich |
| author_sort | Ramin Raul Ossami Saidy |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Development of hepatitis-B is considered a serious complication after liver transplantation. HBV de novo infection is a rather rare phenomenon, however it deserves attention in the era of donor organ shortage. The aim of the present analysis was to examine its course in liver transplant patients. <i>Materials and Methods</i>: Prevalence of de novo HBV-infections was extracted from our local transplant data base. Analysis focused on the moment of HBV-detection and on the long-term follow-up in terms of biochemical and histological changes over 30 years. <i>Results</i>: 46 patients were identified with the diagnosis of de novo hepatitis B. Median time from liver transplantation to diagnosis was 397 days (7–5505). 39 patients received antiviral therapy. No fibrosis progression could be detected, whereas the grade of inflammation significantly lessened from the moment of HBV detection to the end of histological follow-up over a median of 4344 days (range 123–9490). Patients with a poor virological control demonstrated a significantly poorer overall survival. <i>Conclusions</i>: De novo hepatitis B in liver transplant patients is a condition that can be controlled very well without significant fibrosis progression or graft loss if recognized on time within a regular transplant follow-up schedule. |
| first_indexed | 2024-03-10T08:37:03Z |
| format | Article |
| id | doaj.art-67c5eaa2345e4781a0f95bf41a6550d6 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T08:37:03Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-67c5eaa2345e4781a0f95bf41a6550d62023-11-22T08:35:48ZengMDPI AGMedicina1010-660X1648-91442021-07-0157876710.3390/medicina57080767Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver TransplantationRamin Raul Ossami Saidy0Franziska Eurich1Maximilian Paul Postel2Eva Maria Dobrindt3Jasper Feldkamp4Selina Johanna Schaper5Johann Pratschke6Brigitta Globke7Dennis Eurich8Department of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany<i>Background and Objectives</i>: Development of hepatitis-B is considered a serious complication after liver transplantation. HBV de novo infection is a rather rare phenomenon, however it deserves attention in the era of donor organ shortage. The aim of the present analysis was to examine its course in liver transplant patients. <i>Materials and Methods</i>: Prevalence of de novo HBV-infections was extracted from our local transplant data base. Analysis focused on the moment of HBV-detection and on the long-term follow-up in terms of biochemical and histological changes over 30 years. <i>Results</i>: 46 patients were identified with the diagnosis of de novo hepatitis B. Median time from liver transplantation to diagnosis was 397 days (7–5505). 39 patients received antiviral therapy. No fibrosis progression could be detected, whereas the grade of inflammation significantly lessened from the moment of HBV detection to the end of histological follow-up over a median of 4344 days (range 123–9490). Patients with a poor virological control demonstrated a significantly poorer overall survival. <i>Conclusions</i>: De novo hepatitis B in liver transplant patients is a condition that can be controlled very well without significant fibrosis progression or graft loss if recognized on time within a regular transplant follow-up schedule.https://www.mdpi.com/1648-9144/57/8/767viral hepatitisliver transplantationde novo hepatitis B infectionlong-term follow-up |
| spellingShingle | Ramin Raul Ossami Saidy Franziska Eurich Maximilian Paul Postel Eva Maria Dobrindt Jasper Feldkamp Selina Johanna Schaper Johann Pratschke Brigitta Globke Dennis Eurich Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver Transplantation Medicina viral hepatitis liver transplantation de novo hepatitis B infection long-term follow-up |
| title | Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver Transplantation |
| title_full | Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver Transplantation |
| title_fullStr | Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver Transplantation |
| title_full_unstemmed | Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver Transplantation |
| title_short | Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver Transplantation |
| title_sort | clinical and histological long term follow up of de novo hbv infection after liver transplantation |
| topic | viral hepatitis liver transplantation de novo hepatitis B infection long-term follow-up |
| url | https://www.mdpi.com/1648-9144/57/8/767 |
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