Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease

Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease

Objective: Insulin resistance and altered hepatic mitochondrial function are central features of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), but the etiological role of these processes in disease progression remains unclear. Here we investigated the molecular links between i...

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Bibliographic Details
Main Authors:	Chris E. Shannon, Mukundan Ragavan, Juan Pablo Palavicini, Marcel Fourcaudot, Terry M Bakewell, Ivan A. Valdez, Iriscilla Ayala, Eunsook S. Jin, Muniswamy Madesh, Xianlin Han, Matthew E. Merritt, Luke Norton
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Series:	Molecular Metabolism
Subjects:	Insulin resistance Metabolic liver disease Mitochondria Thiazolidinedione Cardiolipin Pyruvate dehydrogenase
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877820302283

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