Metabolic syndrome in Overt and Subclinical Hypothyroidism Syrian Patients
Thyroid hormones play an important role in several metabolic pathways including glucose and lipid metabolism and may cause metabolic syndrome. Both hypothyroidism and metabolic syndrome are common in Syrian population. This study was done to evaluate the metabolic syndrome in two types of hypothyro...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-02-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/8633 |
| _version_ | 1818356017638932480 |
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| author | Madeline Albishara Lama Hadid Shaden Haddad |
| author_facet | Madeline Albishara Lama Hadid Shaden Haddad |
| author_sort | Madeline Albishara |
| collection | DOAJ |
| description |
Thyroid hormones play an important role in several metabolic pathways including glucose and lipid metabolism and may cause metabolic syndrome. Both hypothyroidism and metabolic syndrome are common in Syrian population. This study was done to evaluate the metabolic syndrome in two types of hypothyroidism and the effect of TSH levels on its occurrence. A retrospective cross-sectional study was performed of 91 patients with overt hypothyroidism, 31 patients with subclinical hypothyroidism without clinical symptoms and 53 controls without thyroid disorders. Metabolic syndrome was defined as per International Diabetes Federation(IDF) criteria which are defined as central obesity based on race- and gender-specific WC cutoffs (Waist circumference (WC) ≥ 94cm for male , WC ≥ 80cm for female) plus
any two of the following four parameters: (Raised triglycerides: ≥150 mg/dl (1.7 mmol/l) or history of specific treatment for this lipid abnormality, Reduced HDL cholesterol: < 40 mg/dl (1.03 mmol/l) in males and < 50 mg/dl (1.29 mmol/l) in females or history of specific treatment for this lipid abnormality, Raised blood pressure: systolic BP ≥130 mm Hg or diastolic BP ≥85 mm Hg or on treatment for previously diagnosed hypertension and Raised FPG: ≥ 100 mg/dl or previously diagnosed type 2 Diabetes mellitus
In conclusion, our study showed significant association between overt hypothyroidism and metabolic syndrome. It also revealed that TSH level over 2.5 uIU/ml significantly increases the risk of the metabolic syndrome.
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| first_indexed | 2024-12-13T19:50:32Z |
| format | Article |
| id | doaj.art-67ccce7c12c943f5b3740a8b55c6325d |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-13T19:50:32Z |
| publishDate | 2022-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-67ccce7c12c943f5b3740a8b55c6325d2022-12-21T23:33:26ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942022-02-0160210.18502/acta.v60i2.8822Metabolic syndrome in Overt and Subclinical Hypothyroidism Syrian PatientsMadeline Albishara0Lama Hadid1Shaden Haddad2Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, SyriaDepartment of Endocrinology, Al-Assad University Hospital, Damascus, SyriaDepartment of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria. Thyroid hormones play an important role in several metabolic pathways including glucose and lipid metabolism and may cause metabolic syndrome. Both hypothyroidism and metabolic syndrome are common in Syrian population. This study was done to evaluate the metabolic syndrome in two types of hypothyroidism and the effect of TSH levels on its occurrence. A retrospective cross-sectional study was performed of 91 patients with overt hypothyroidism, 31 patients with subclinical hypothyroidism without clinical symptoms and 53 controls without thyroid disorders. Metabolic syndrome was defined as per International Diabetes Federation(IDF) criteria which are defined as central obesity based on race- and gender-specific WC cutoffs (Waist circumference (WC) ≥ 94cm for male , WC ≥ 80cm for female) plus any two of the following four parameters: (Raised triglycerides: ≥150 mg/dl (1.7 mmol/l) or history of specific treatment for this lipid abnormality, Reduced HDL cholesterol: < 40 mg/dl (1.03 mmol/l) in males and < 50 mg/dl (1.29 mmol/l) in females or history of specific treatment for this lipid abnormality, Raised blood pressure: systolic BP ≥130 mm Hg or diastolic BP ≥85 mm Hg or on treatment for previously diagnosed hypertension and Raised FPG: ≥ 100 mg/dl or previously diagnosed type 2 Diabetes mellitus In conclusion, our study showed significant association between overt hypothyroidism and metabolic syndrome. It also revealed that TSH level over 2.5 uIU/ml significantly increases the risk of the metabolic syndrome. https://acta.tums.ac.ir/index.php/acta/article/view/8633Overt hypothyroidismSubclinical hypothyroidismMetabolic syndromeThyroid-stimulating hormoneObesity |
| spellingShingle | Madeline Albishara Lama Hadid Shaden Haddad Metabolic syndrome in Overt and Subclinical Hypothyroidism Syrian Patients Acta Medica Iranica Overt hypothyroidism Subclinical hypothyroidism Metabolic syndrome Thyroid-stimulating hormone Obesity |
| title | Metabolic syndrome in Overt and Subclinical Hypothyroidism Syrian Patients |
| title_full | Metabolic syndrome in Overt and Subclinical Hypothyroidism Syrian Patients |
| title_fullStr | Metabolic syndrome in Overt and Subclinical Hypothyroidism Syrian Patients |
| title_full_unstemmed | Metabolic syndrome in Overt and Subclinical Hypothyroidism Syrian Patients |
| title_short | Metabolic syndrome in Overt and Subclinical Hypothyroidism Syrian Patients |
| title_sort | metabolic syndrome in overt and subclinical hypothyroidism syrian patients |
| topic | Overt hypothyroidism Subclinical hypothyroidism Metabolic syndrome Thyroid-stimulating hormone Obesity |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/8633 |
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