The Role of Neuroglia in Administrating Nerve Blockers and Anesthesia to Patients
Dysfunction of the neuroglia can have profound consequences on the blood–brain barrier (BBB). Studies have shown that the disruption of astrocytic–endothelial interaction can compromise the permeability of BBB and its effectiveness in selectively regulating the exchange of substances. Microglia have...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Neuroglia |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2571-6980/5/1/2 |
| _version_ | 1797239795433340928 |
|---|---|
| author | Anjali Patel Raja Al-Bahou Rajvi Thakkar Drashti Patel Devon Foster Jonathan Benjamin Marian Pedreira Brandon Lucke-Wold |
| author_facet | Anjali Patel Raja Al-Bahou Rajvi Thakkar Drashti Patel Devon Foster Jonathan Benjamin Marian Pedreira Brandon Lucke-Wold |
| author_sort | Anjali Patel |
| collection | DOAJ |
| description | Dysfunction of the neuroglia can have profound consequences on the blood–brain barrier (BBB). Studies have shown that the disruption of astrocytic–endothelial interaction can compromise the permeability of BBB and its effectiveness in selectively regulating the exchange of substances. Microglia have recently been recognized to have a significant role in the initiation of chronic pain and in its interactions with various nerve blockers and anesthetic agents. Microglia have a role in pain resolution via a pathway that involves Cannabinoid receptor type 2 activation and MAP kinase phosphorylation. Understanding the role of these cells in the context of neuropathic pain and neurological disorders can aid in improving clinical outcomes and the challenging nature of managing pain. Advancing studies have proposed pharmacological and genetic modulation of microglia as a potential treatment option for patients with chronic pain. |
| first_indexed | 2024-04-24T17:57:13Z |
| format | Article |
| id | doaj.art-67cd0a821d4f438a8ca22e480a5199ea |
| institution | Directory Open Access Journal |
| issn | 2571-6980 |
| language | English |
| last_indexed | 2024-04-24T17:57:13Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neuroglia |
| spelling | doaj.art-67cd0a821d4f438a8ca22e480a5199ea2024-03-27T13:57:43ZengMDPI AGNeuroglia2571-69802024-01-0151132610.3390/neuroglia5010002The Role of Neuroglia in Administrating Nerve Blockers and Anesthesia to PatientsAnjali Patel0Raja Al-Bahou1Rajvi Thakkar2Drashti Patel3Devon Foster4Jonathan Benjamin5Marian Pedreira6Brandon Lucke-Wold7College of Medicine, University of Florida, Gainesville, FL 32601, USACollege of Medicine, University of Florida, Gainesville, FL 32601, USACollege of Medicine, University of Florida, Gainesville, FL 32601, USACollege of Medicine, University of Florida, Gainesville, FL 32601, USAHerbert Wertheim College of Medicine, Florida International University, Miami, FL 32601, USACollege of Medicine, University of Florida, Gainesville, FL 32601, USAEdward Via College of Osteopathic Medicine, Blacksburg, VA 24112, USADepartment of Neurosurgery, University of Florida, Gainesville, FL 32601, USADysfunction of the neuroglia can have profound consequences on the blood–brain barrier (BBB). Studies have shown that the disruption of astrocytic–endothelial interaction can compromise the permeability of BBB and its effectiveness in selectively regulating the exchange of substances. Microglia have recently been recognized to have a significant role in the initiation of chronic pain and in its interactions with various nerve blockers and anesthetic agents. Microglia have a role in pain resolution via a pathway that involves Cannabinoid receptor type 2 activation and MAP kinase phosphorylation. Understanding the role of these cells in the context of neuropathic pain and neurological disorders can aid in improving clinical outcomes and the challenging nature of managing pain. Advancing studies have proposed pharmacological and genetic modulation of microglia as a potential treatment option for patients with chronic pain.https://www.mdpi.com/2571-6980/5/1/2neurogliablood–brain barrierMAP kinase phosphorylationchronic pain |
| spellingShingle | Anjali Patel Raja Al-Bahou Rajvi Thakkar Drashti Patel Devon Foster Jonathan Benjamin Marian Pedreira Brandon Lucke-Wold The Role of Neuroglia in Administrating Nerve Blockers and Anesthesia to Patients Neuroglia neuroglia blood–brain barrier MAP kinase phosphorylation chronic pain |
| title | The Role of Neuroglia in Administrating Nerve Blockers and Anesthesia to Patients |
| title_full | The Role of Neuroglia in Administrating Nerve Blockers and Anesthesia to Patients |
| title_fullStr | The Role of Neuroglia in Administrating Nerve Blockers and Anesthesia to Patients |
| title_full_unstemmed | The Role of Neuroglia in Administrating Nerve Blockers and Anesthesia to Patients |
| title_short | The Role of Neuroglia in Administrating Nerve Blockers and Anesthesia to Patients |
| title_sort | role of neuroglia in administrating nerve blockers and anesthesia to patients |
| topic | neuroglia blood–brain barrier MAP kinase phosphorylation chronic pain |
| url | https://www.mdpi.com/2571-6980/5/1/2 |
| work_keys_str_mv | AT anjalipatel theroleofneurogliainadministratingnerveblockersandanesthesiatopatients AT rajaalbahou theroleofneurogliainadministratingnerveblockersandanesthesiatopatients AT rajvithakkar theroleofneurogliainadministratingnerveblockersandanesthesiatopatients AT drashtipatel theroleofneurogliainadministratingnerveblockersandanesthesiatopatients AT devonfoster theroleofneurogliainadministratingnerveblockersandanesthesiatopatients AT jonathanbenjamin theroleofneurogliainadministratingnerveblockersandanesthesiatopatients AT marianpedreira theroleofneurogliainadministratingnerveblockersandanesthesiatopatients AT brandonluckewold theroleofneurogliainadministratingnerveblockersandanesthesiatopatients AT anjalipatel roleofneurogliainadministratingnerveblockersandanesthesiatopatients AT rajaalbahou roleofneurogliainadministratingnerveblockersandanesthesiatopatients AT rajvithakkar roleofneurogliainadministratingnerveblockersandanesthesiatopatients AT drashtipatel roleofneurogliainadministratingnerveblockersandanesthesiatopatients AT devonfoster roleofneurogliainadministratingnerveblockersandanesthesiatopatients AT jonathanbenjamin roleofneurogliainadministratingnerveblockersandanesthesiatopatients AT marianpedreira roleofneurogliainadministratingnerveblockersandanesthesiatopatients AT brandonluckewold roleofneurogliainadministratingnerveblockersandanesthesiatopatients |