Alitretinoin for the treatment of severe chronic hand eczema
Thomas King, John McKenna, Anton B Alexandroff Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK Abstract: Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic acid and pan-retinoic acid agonist, is a n...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2014-11-01
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| Series: | Patient Preference and Adherence |
| Online Access: | http://www.dovepress.com/alitretinoin-for-the-treatment-of-severe-chronic-hand-eczema-peer-reviewed-article-PPA |
| _version_ | 1811278111510102016 |
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| author | King T McKenna J Alexandroff AB |
| author_facet | King T McKenna J Alexandroff AB |
| author_sort | King T |
| collection | DOAJ |
| description | Thomas King, John McKenna, Anton B Alexandroff Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK Abstract: Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic acid and pan-retinoic acid agonist, is a new and effective systemic treatment for chronic hand eczema, which provides another treatment option. A “clear” or “almost clear” response can be achieved in up to half of patients within a 24-week course of treatment. Even higher rates of remission can be obtained with a longer duration of treatment. Alitretinoin has a favorable overall profile of adverse effects; however, female patients who are at risk of becoming pregnant should follow a strict pregnancy-prevention program due to the teratogenic effects of this drug. Keywords: dermatitis, toctino, CTCL |
| first_indexed | 2024-04-13T00:29:55Z |
| format | Article |
| id | doaj.art-67ced3d1a7ca4c5a9971af73ab844a99 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-04-13T00:29:55Z |
| publishDate | 2014-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-67ced3d1a7ca4c5a9971af73ab844a992022-12-22T03:10:30ZengDove Medical PressPatient Preference and Adherence1177-889X2014-11-012014default1629163419280Alitretinoin for the treatment of severe chronic hand eczemaKing TMcKenna JAlexandroff ABThomas King, John McKenna, Anton B Alexandroff Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK Abstract: Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic acid and pan-retinoic acid agonist, is a new and effective systemic treatment for chronic hand eczema, which provides another treatment option. A “clear” or “almost clear” response can be achieved in up to half of patients within a 24-week course of treatment. Even higher rates of remission can be obtained with a longer duration of treatment. Alitretinoin has a favorable overall profile of adverse effects; however, female patients who are at risk of becoming pregnant should follow a strict pregnancy-prevention program due to the teratogenic effects of this drug. Keywords: dermatitis, toctino, CTCLhttp://www.dovepress.com/alitretinoin-for-the-treatment-of-severe-chronic-hand-eczema-peer-reviewed-article-PPA |
| spellingShingle | King T McKenna J Alexandroff AB Alitretinoin for the treatment of severe chronic hand eczema Patient Preference and Adherence |
| title | Alitretinoin for the treatment of severe chronic hand eczema |
| title_full | Alitretinoin for the treatment of severe chronic hand eczema |
| title_fullStr | Alitretinoin for the treatment of severe chronic hand eczema |
| title_full_unstemmed | Alitretinoin for the treatment of severe chronic hand eczema |
| title_short | Alitretinoin for the treatment of severe chronic hand eczema |
| title_sort | alitretinoin for the treatment of severe chronic hand eczema |
| url | http://www.dovepress.com/alitretinoin-for-the-treatment-of-severe-chronic-hand-eczema-peer-reviewed-article-PPA |
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