The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South Africa
Background: The prevalence of hepatitis B virus (HBV) amongst South African infants and children has been reported in the pre-HIV era. Despite the reported high prevalence of HIV in the general population of South Africa, the rate of HIV/HBV co-infection amongst infants and children remains poorly r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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AOSIS
2016-03-01
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| Series: | African Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | https://ajlmonline.org/index.php/ajlm/article/view/283 |
| _version_ | 1817971194914144256 |
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| author | Nokukhanya Mdlalose Raveen Parboosing Pravi Moodley |
| author_facet | Nokukhanya Mdlalose Raveen Parboosing Pravi Moodley |
| author_sort | Nokukhanya Mdlalose |
| collection | DOAJ |
| description | Background: The prevalence of hepatitis B virus (HBV) amongst South African infants and children has been reported in the pre-HIV era. Despite the reported high prevalence of HIV in the general population of South Africa, the rate of HIV/HBV co-infection amongst infants and children remains poorly reported.
Objectives: We describe the prevalence of HBV infection amongst HIV-positive and HIV-negative infants by molecular methods of diagnosis using dried blood spot samples.
Methods: This retrospective cross-sectional study was conducted between July 2011 and December 2011 in an academic referral laboratory offering viral diagnostic services to the entire KwaZulu-Natal province of South Africa. A total of 322 study samples were collected from discarded residual dried blood spot samples following routine infant diagnosis of HIV. Equal proportions of HIV-positive and HIV-negative infant specimens were studied. Statistical differences in the prevalence of HBV between the HIV-positive and HIV-negative samples were calculated using the Pearson chi-square test, and a p-value < 0.05 was considered statistically significant. Further testing for HBV DNA using a nested polymerase chain reaction method was performed.
Results: The overall prevalence of HBV was 10%. In the HIV-positive group, 21 of 161 infants tested positive for HBV compared with 12 of 161 HIV-negative infants who tested positive for HBV. The proportion of infants infected with HBV was marginally higher amongst HIV positiveinfants (13.0%; 95% CI 6.8–19.9) compared with HIV-negative infants (7.5%; 95% C I2.5–13.7; P = 0.098), though not statistically significant.
Conclusion: The finding of a 10% HBV prevalence in this infant cohort is clinically significant. The non-statistically significant difference in HBV prevalence between the HIV-positive and HIV-negative infants suggests that high prevalence of HBV infection in children may be a problem independent of HIV. |
| first_indexed | 2024-04-13T20:43:32Z |
| format | Article |
| id | doaj.art-67cedc68b727498bb7f1ee103f4f2379 |
| institution | Directory Open Access Journal |
| issn | 2225-2002 2225-2010 |
| language | English |
| last_indexed | 2024-04-13T20:43:32Z |
| publishDate | 2016-03-01 |
| publisher | AOSIS |
| record_format | Article |
| series | African Journal of Laboratory Medicine |
| spelling | doaj.art-67cedc68b727498bb7f1ee103f4f23792022-12-22T02:30:45ZengAOSISAfrican Journal of Laboratory Medicine2225-20022225-20102016-03-0151e1e510.4102/ajlm.v5i1.283106The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South AfricaNokukhanya Mdlalose0Raveen Parboosing1Pravi Moodley2Department of Virology, National Health Laboratory Service, University of KwaZulu-NatalDepartment of Virology, National Health Laboratory Service, University of KwaZulu-NatalDepartment of Virology, National Health Laboratory Service, University of KwaZulu-NatalBackground: The prevalence of hepatitis B virus (HBV) amongst South African infants and children has been reported in the pre-HIV era. Despite the reported high prevalence of HIV in the general population of South Africa, the rate of HIV/HBV co-infection amongst infants and children remains poorly reported. Objectives: We describe the prevalence of HBV infection amongst HIV-positive and HIV-negative infants by molecular methods of diagnosis using dried blood spot samples. Methods: This retrospective cross-sectional study was conducted between July 2011 and December 2011 in an academic referral laboratory offering viral diagnostic services to the entire KwaZulu-Natal province of South Africa. A total of 322 study samples were collected from discarded residual dried blood spot samples following routine infant diagnosis of HIV. Equal proportions of HIV-positive and HIV-negative infant specimens were studied. Statistical differences in the prevalence of HBV between the HIV-positive and HIV-negative samples were calculated using the Pearson chi-square test, and a p-value < 0.05 was considered statistically significant. Further testing for HBV DNA using a nested polymerase chain reaction method was performed. Results: The overall prevalence of HBV was 10%. In the HIV-positive group, 21 of 161 infants tested positive for HBV compared with 12 of 161 HIV-negative infants who tested positive for HBV. The proportion of infants infected with HBV was marginally higher amongst HIV positiveinfants (13.0%; 95% CI 6.8–19.9) compared with HIV-negative infants (7.5%; 95% C I2.5–13.7; P = 0.098), though not statistically significant. Conclusion: The finding of a 10% HBV prevalence in this infant cohort is clinically significant. The non-statistically significant difference in HBV prevalence between the HIV-positive and HIV-negative infants suggests that high prevalence of HBV infection in children may be a problem independent of HIV.https://ajlmonline.org/index.php/ajlm/article/view/283Hepatitis B virusInfantsSouth Africa |
| spellingShingle | Nokukhanya Mdlalose Raveen Parboosing Pravi Moodley The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South Africa African Journal of Laboratory Medicine Hepatitis B virus Infants South Africa |
| title | The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South Africa |
| title_full | The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South Africa |
| title_fullStr | The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South Africa |
| title_full_unstemmed | The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South Africa |
| title_short | The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South Africa |
| title_sort | prevalence of hepatitis b virus infection in hiv positive and hiv negative infants kwazulu natal south africa |
| topic | Hepatitis B virus Infants South Africa |
| url | https://ajlmonline.org/index.php/ajlm/article/view/283 |
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