Study of the biological properties of new chemical compounds of the pyrimidine series
In order to study the effect of a number of 6-substituted uracil derivatives on bovine embryo lung cells, experiments were conducted. According to the study, the effect of the studied substances on the cultural and morphological properties of cell was determined by taking into account their viabilit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/16/e3sconf_agritech-ix2023_04004.pdf |
| _version_ | 1797315650357559296 |
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| author | Egorov Vladislav Valiullin Lenar Raginov Ivan Grabovskiy Stanislav Gafiyatov Rinat Artemenko Alexander Zakharenko Alexander Golokhvast Kirill |
| author_facet | Egorov Vladislav Valiullin Lenar Raginov Ivan Grabovskiy Stanislav Gafiyatov Rinat Artemenko Alexander Zakharenko Alexander Golokhvast Kirill |
| author_sort | Egorov Vladislav |
| collection | DOAJ |
| description | In order to study the effect of a number of 6-substituted uracil derivatives on bovine embryo lung cells, experiments were conducted. According to the study, the effect of the studied substances on the cultural and morphological properties of cell was determined by taking into account their viability and proliferation index. In %, it was calculated that viability was determined by the ratio of living cells to their total number. The proliferation index was determined as the ratio of the number of proliferating cells to the number of seeded cells. At 0.1 mM concentration of the compounds studied, a decrease in LEK cell viability was recorded compared to the control group, but this was only the case for compound No. 2. When other compounds were used at doses of 0.1 mM, LEK cell viability increased by 3.0-7.0% compared to controls. Increasing the dose of the compounds studied to 1.0 mM results in a 10.0% decrease in survival in the presence of compounds No. 3 and 6, 16.0% in the presence of compounds No. 2 and 7, 19.0% in the presence of compound No. 4 and 25.0% in the presence of compounds No. 8 and 9. |
| first_indexed | 2024-03-08T03:06:53Z |
| format | Article |
| id | doaj.art-67cf5c90971c456e8142c7c6877e20e6 |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-03-08T03:06:53Z |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-67cf5c90971c456e8142c7c6877e20e62024-02-13T08:28:05ZengEDP SciencesE3S Web of Conferences2267-12422024-01-014860400410.1051/e3sconf/202448604004e3sconf_agritech-ix2023_04004Study of the biological properties of new chemical compounds of the pyrimidine seriesEgorov Vladislav0Valiullin Lenar1Raginov Ivan2Grabovskiy Stanislav3Gafiyatov Rinat4Artemenko Alexander5Zakharenko Alexander6Golokhvast Kirill7Kazan State Agrarian UniversityFederal Center for Toxicological, Radiation and Biological SafetyKazan State Medical UniversityUfa Institute of Chemistry of the Russian Academy of SciencesKazan State Agrarian UniversitySiberian Federal Scientific Center of Agrobiotechnology RASSiberian Federal Scientific Center of Agrobiotechnology RASSiberian Federal Scientific Center of Agrobiotechnology RASIn order to study the effect of a number of 6-substituted uracil derivatives on bovine embryo lung cells, experiments were conducted. According to the study, the effect of the studied substances on the cultural and morphological properties of cell was determined by taking into account their viability and proliferation index. In %, it was calculated that viability was determined by the ratio of living cells to their total number. The proliferation index was determined as the ratio of the number of proliferating cells to the number of seeded cells. At 0.1 mM concentration of the compounds studied, a decrease in LEK cell viability was recorded compared to the control group, but this was only the case for compound No. 2. When other compounds were used at doses of 0.1 mM, LEK cell viability increased by 3.0-7.0% compared to controls. Increasing the dose of the compounds studied to 1.0 mM results in a 10.0% decrease in survival in the presence of compounds No. 3 and 6, 16.0% in the presence of compounds No. 2 and 7, 19.0% in the presence of compound No. 4 and 25.0% in the presence of compounds No. 8 and 9.https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/16/e3sconf_agritech-ix2023_04004.pdf |
| spellingShingle | Egorov Vladislav Valiullin Lenar Raginov Ivan Grabovskiy Stanislav Gafiyatov Rinat Artemenko Alexander Zakharenko Alexander Golokhvast Kirill Study of the biological properties of new chemical compounds of the pyrimidine series E3S Web of Conferences |
| title | Study of the biological properties of new chemical compounds of the pyrimidine series |
| title_full | Study of the biological properties of new chemical compounds of the pyrimidine series |
| title_fullStr | Study of the biological properties of new chemical compounds of the pyrimidine series |
| title_full_unstemmed | Study of the biological properties of new chemical compounds of the pyrimidine series |
| title_short | Study of the biological properties of new chemical compounds of the pyrimidine series |
| title_sort | study of the biological properties of new chemical compounds of the pyrimidine series |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2024/16/e3sconf_agritech-ix2023_04004.pdf |
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