Establishing the relationship between Polycyclic Aromatic Hydrocarbons (PAHs) exposure and male infertility: A systematic review
It has been demonstrated that human exposure to environmental chemicals may have sperm genotoxic potentiality. Among the different classes, Polycyclic Aromatic Hydrocarbons (PAHs) have been receiving attention in recent years due to reports of sperm geno-toxicity, a series of reproductive defects an...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322013252 |
| _version_ | 1797952850489245696 |
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| author | Babak Kakavandi Hossein Rafiemanesh Stefanos Giannakis Fatemeh Beheshtaeen Sofia Samoili Masoumeh Hashemi Fatemeh Abdi |
| author_facet | Babak Kakavandi Hossein Rafiemanesh Stefanos Giannakis Fatemeh Beheshtaeen Sofia Samoili Masoumeh Hashemi Fatemeh Abdi |
| author_sort | Babak Kakavandi |
| collection | DOAJ |
| description | It has been demonstrated that human exposure to environmental chemicals may have sperm genotoxic potentiality. Among the different classes, Polycyclic Aromatic Hydrocarbons (PAHs) have been receiving attention in recent years due to reports of sperm geno-toxicity, a series of reproductive defects and male infertility. This review aims to substantiate the effects of PAHs exposure on male infertility, with focus on the sperm characteristics (count, concentration, volume, motility, DNA damage, and morphology). To this end, international databases such as Cochrane Library, PubMed, Web of Science, Embase Ovid, Scopus, and Google Scholar were used to conduct a systematic search for papers on the subject, based on PRISMA guidelines, published up to 24 March 2022. The Newcastle-Ottawa Scale was subsequently used to assess the quality of the studies. The results showed that there is a significant negative relationship between PAHs metabolites and sperm volume, concentration, motility, morphology, as well as an observed DNA degeneration. Also, the CYP1A1 genotype polymorphisms were considered as a representative of PAHs exposure to infertility; the review highlights that polymorphisms of this genotype were more common in the infertile people. In overall, this work provides a solid summary of the existing works correlating PAHs exposure and male infertility, which could impulse further protective measures and informative campaigns on users, workers, and general population. |
| first_indexed | 2024-04-10T22:52:33Z |
| format | Article |
| id | doaj.art-67d30a14080540a499a17e8b30a6a2c4 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-10T22:52:33Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-67d30a14080540a499a17e8b30a6a2c42023-01-15T04:20:59ZengElsevierEcotoxicology and Environmental Safety0147-65132023-01-01250114485Establishing the relationship between Polycyclic Aromatic Hydrocarbons (PAHs) exposure and male infertility: A systematic reviewBabak Kakavandi0Hossein Rafiemanesh1Stefanos Giannakis2Fatemeh Beheshtaeen3Sofia Samoili4Masoumeh Hashemi5Fatemeh Abdi6Research Center for Health, Safety and Environment, Alborz University of Medical Sciences, Karaj, Iran; Department of Environmental Health Engineering, Alborz University of Medical Sciences, Karaj, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Alborz University of Medical Sciences, Karaj, Iran; Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, IranUniversidad Politécnica de Madrid, E.T.S. Ingenieros de Caminos, Canales y Puertos, Departamento de Ingeniería Civil: Hidráulica, Energía y Medio Ambiente, Unidad docente Ingeniería Sanitaria, c/ Profesor Aranguren, s/n, ES-28040 Madrid, SpainStudent research committee, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, IranEuropean Commission, Joint Research Centre (JRC), Seville 41092, SpainDepartment of Midwifery, Arak Branch, Islamic Azad University, Arak, IranNon-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran; Corresponding author.It has been demonstrated that human exposure to environmental chemicals may have sperm genotoxic potentiality. Among the different classes, Polycyclic Aromatic Hydrocarbons (PAHs) have been receiving attention in recent years due to reports of sperm geno-toxicity, a series of reproductive defects and male infertility. This review aims to substantiate the effects of PAHs exposure on male infertility, with focus on the sperm characteristics (count, concentration, volume, motility, DNA damage, and morphology). To this end, international databases such as Cochrane Library, PubMed, Web of Science, Embase Ovid, Scopus, and Google Scholar were used to conduct a systematic search for papers on the subject, based on PRISMA guidelines, published up to 24 March 2022. The Newcastle-Ottawa Scale was subsequently used to assess the quality of the studies. The results showed that there is a significant negative relationship between PAHs metabolites and sperm volume, concentration, motility, morphology, as well as an observed DNA degeneration. Also, the CYP1A1 genotype polymorphisms were considered as a representative of PAHs exposure to infertility; the review highlights that polymorphisms of this genotype were more common in the infertile people. In overall, this work provides a solid summary of the existing works correlating PAHs exposure and male infertility, which could impulse further protective measures and informative campaigns on users, workers, and general population.http://www.sciencedirect.com/science/article/pii/S0147651322013252Polycyclic aromatic hydrocarbonsMale infertilityEnvironmental exposureEndocrine disruptionAtmospheric toxicant |
| spellingShingle | Babak Kakavandi Hossein Rafiemanesh Stefanos Giannakis Fatemeh Beheshtaeen Sofia Samoili Masoumeh Hashemi Fatemeh Abdi Establishing the relationship between Polycyclic Aromatic Hydrocarbons (PAHs) exposure and male infertility: A systematic review Ecotoxicology and Environmental Safety Polycyclic aromatic hydrocarbons Male infertility Environmental exposure Endocrine disruption Atmospheric toxicant |
| title | Establishing the relationship between Polycyclic Aromatic Hydrocarbons (PAHs) exposure and male infertility: A systematic review |
| title_full | Establishing the relationship between Polycyclic Aromatic Hydrocarbons (PAHs) exposure and male infertility: A systematic review |
| title_fullStr | Establishing the relationship between Polycyclic Aromatic Hydrocarbons (PAHs) exposure and male infertility: A systematic review |
| title_full_unstemmed | Establishing the relationship between Polycyclic Aromatic Hydrocarbons (PAHs) exposure and male infertility: A systematic review |
| title_short | Establishing the relationship between Polycyclic Aromatic Hydrocarbons (PAHs) exposure and male infertility: A systematic review |
| title_sort | establishing the relationship between polycyclic aromatic hydrocarbons pahs exposure and male infertility a systematic review |
| topic | Polycyclic aromatic hydrocarbons Male infertility Environmental exposure Endocrine disruption Atmospheric toxicant |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322013252 |
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