Genetic Features of a Representative Panel of 110 Meningococcal B Isolates to Assess the Efficacy of Meningococcal B Vaccines

Genetic Features of a Representative Panel of 110 Meningococcal B Isolates to Assess the Efficacy of Meningococcal B Vaccines

ABSTRACT Predictions of vaccine efficacy against Neisseria meningitidis serogroup B (NmB) disease are hindered by antigenic variability, limiting the representativeness of individual NmB isolates. A qualitative human serum bactericidal assay using endogenous complements of individual subjects (enc-h...

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Bibliographic Details
Main Authors: Alessandro Muzzi, Margherita Bodini, Nadav Topaz, Vega Masignani, Kumaran Vadivelu, Henju Marjuki, Xin Wang, Laura Serino, Duccio Medini
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mSphere
Subjects:
meningococcal disease
4CMenB
MenB-FHbp
vaccine effectiveness
serogroup B
bacterial isolates
Online Access:https://journals.asm.org/doi/10.1128/msphere.00385-22

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