Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses
Vector-borne diseases are responsible for over a billion infections each year and nearly one million deaths. Mosquito-borne dengue virus, West Nile, Japanese encephalitis, Zika, Chikungunya, and Rift Valley Fever viruses constitute major public health problems in regions with high densities of arthr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00407/full |
| _version_ | 1819142877508272128 |
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| author | David Guerrero Tineke Cantaert Dorothée Missé |
| author_facet | David Guerrero Tineke Cantaert Dorothée Missé |
| author_sort | David Guerrero |
| collection | DOAJ |
| description | Vector-borne diseases are responsible for over a billion infections each year and nearly one million deaths. Mosquito-borne dengue virus, West Nile, Japanese encephalitis, Zika, Chikungunya, and Rift Valley Fever viruses constitute major public health problems in regions with high densities of arthropod vectors. During the initial step of the transmission cycle, vector, host, and virus converge at the bite site, where local immune cells interact with the vector's saliva. Hematophagous mosquito saliva is a mixture of bioactive components known to modulate vertebrate hemostasis, immunity, and inflammation during the insect's feeding process. The capacity of mosquito saliva to modulate the host immune response has been well-studied over the last few decades and has led to the consensus that the presence of saliva is linked to the enhancement of virus transmission, host susceptibility, disease progression, viremia levels, and mortality. We review some of the major aspects of the interactions between mosquito saliva and the host immune response that may be useful for future studies on the control of arboviruses. |
| first_indexed | 2024-12-22T12:17:20Z |
| format | Article |
| id | doaj.art-67d42c1148eb45cebf07a2ecf5272384 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T12:17:20Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-67d42c1148eb45cebf07a2ecf52723842022-12-21T18:26:05ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-08-011010.3389/fcimb.2020.00407549268Aedes Mosquito Salivary Components and Their Effect on the Immune Response to ArbovirusesDavid Guerrero0Tineke Cantaert1Dorothée Missé2Immunology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, CambodiaImmunology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, CambodiaMIVEGEC, IRD, University of Montpellier, CNRS, Montpellier, FranceVector-borne diseases are responsible for over a billion infections each year and nearly one million deaths. Mosquito-borne dengue virus, West Nile, Japanese encephalitis, Zika, Chikungunya, and Rift Valley Fever viruses constitute major public health problems in regions with high densities of arthropod vectors. During the initial step of the transmission cycle, vector, host, and virus converge at the bite site, where local immune cells interact with the vector's saliva. Hematophagous mosquito saliva is a mixture of bioactive components known to modulate vertebrate hemostasis, immunity, and inflammation during the insect's feeding process. The capacity of mosquito saliva to modulate the host immune response has been well-studied over the last few decades and has led to the consensus that the presence of saliva is linked to the enhancement of virus transmission, host susceptibility, disease progression, viremia levels, and mortality. We review some of the major aspects of the interactions between mosquito saliva and the host immune response that may be useful for future studies on the control of arboviruses.https://www.frontiersin.org/article/10.3389/fcimb.2020.00407/fullarbovirusmosquito salivaimmune responsesaliva compositionAedes spp |
| spellingShingle | David Guerrero Tineke Cantaert Dorothée Missé Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses Frontiers in Cellular and Infection Microbiology arbovirus mosquito saliva immune response saliva composition Aedes spp |
| title | Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses |
| title_full | Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses |
| title_fullStr | Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses |
| title_full_unstemmed | Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses |
| title_short | Aedes Mosquito Salivary Components and Their Effect on the Immune Response to Arboviruses |
| title_sort | aedes mosquito salivary components and their effect on the immune response to arboviruses |
| topic | arbovirus mosquito saliva immune response saliva composition Aedes spp |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2020.00407/full |
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