Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms
Since the theory of modern anatomical partitioning of the prostate was proposed, the differences in the incidence and pathological parameters of prostate cancer between the peripheral zone and transition zone have been gradually revealed. It suggests that there are differences in the pathogenic path...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1165732/full |
| _version_ | 1797791169251377152 |
|---|---|
| author | Xudong Yu Xudong Yu Ruijia Liu Lianying Song Wenfeng Gao Xuyun Wang Yaosheng Zhang Yaosheng Zhang |
| author_facet | Xudong Yu Xudong Yu Ruijia Liu Lianying Song Wenfeng Gao Xuyun Wang Yaosheng Zhang Yaosheng Zhang |
| author_sort | Xudong Yu |
| collection | DOAJ |
| description | Since the theory of modern anatomical partitioning of the prostate was proposed, the differences in the incidence and pathological parameters of prostate cancer between the peripheral zone and transition zone have been gradually revealed. It suggests that there are differences in the pathogenic pathways and molecular biology of prostate cancer between different regions of origin. Over the past decade, advances in sequencing technologies have revealed more about molecules, genomes, and cell types specific to the peripheral and transitional zones. In recent years, the innovation of spatial imaging and multiple-parameter magnetic resonance imaging has provided new technical support for the zonal study of prostate cancer. In this work, we reviewed all the research results and the latest research progress in the study of prostate cancer in the past two decades. We summarized and proposed several vital issues and focused directions for understanding the differences between peripheral and transitional zones in prostate cancer. |
| first_indexed | 2024-03-13T02:14:59Z |
| format | Article |
| id | doaj.art-67d53b4e89d142789d41cbdffa57bcd3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T02:14:59Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-67d53b4e89d142789d41cbdffa57bcd32023-06-30T16:35:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11657321165732Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanismsXudong Yu0Xudong Yu1Ruijia Liu2Lianying Song3Wenfeng Gao4Xuyun Wang5Yaosheng Zhang6Yaosheng Zhang7Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaBeijing Tumor Minimally Invasive Medical Center of Integrated Traditional Chinese and Western Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine and Beijing Municipal Health Commission, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaBeijing Tumor Minimally Invasive Medical Center of Integrated Traditional Chinese and Western Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine and Beijing Municipal Health Commission, Beijing, ChinaSince the theory of modern anatomical partitioning of the prostate was proposed, the differences in the incidence and pathological parameters of prostate cancer between the peripheral zone and transition zone have been gradually revealed. It suggests that there are differences in the pathogenic pathways and molecular biology of prostate cancer between different regions of origin. Over the past decade, advances in sequencing technologies have revealed more about molecules, genomes, and cell types specific to the peripheral and transitional zones. In recent years, the innovation of spatial imaging and multiple-parameter magnetic resonance imaging has provided new technical support for the zonal study of prostate cancer. In this work, we reviewed all the research results and the latest research progress in the study of prostate cancer in the past two decades. We summarized and proposed several vital issues and focused directions for understanding the differences between peripheral and transitional zones in prostate cancer.https://www.frontiersin.org/articles/10.3389/fonc.2023.1165732/fullprostate cancerzonesclinical charactersheterogeneityMRI |
| spellingShingle | Xudong Yu Xudong Yu Ruijia Liu Lianying Song Wenfeng Gao Xuyun Wang Yaosheng Zhang Yaosheng Zhang Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms Frontiers in Oncology prostate cancer zones clinical characters heterogeneity MRI |
| title | Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms |
| title_full | Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms |
| title_fullStr | Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms |
| title_full_unstemmed | Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms |
| title_short | Differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms |
| title_sort | differences in the pathogenetic characteristics of prostate cancer in the transitional and peripheral zones and the possible molecular biological mechanisms |
| topic | prostate cancer zones clinical characters heterogeneity MRI |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1165732/full |
| work_keys_str_mv | AT xudongyu differencesinthepathogeneticcharacteristicsofprostatecancerinthetransitionalandperipheralzonesandthepossiblemolecularbiologicalmechanisms AT xudongyu differencesinthepathogeneticcharacteristicsofprostatecancerinthetransitionalandperipheralzonesandthepossiblemolecularbiologicalmechanisms AT ruijialiu differencesinthepathogeneticcharacteristicsofprostatecancerinthetransitionalandperipheralzonesandthepossiblemolecularbiologicalmechanisms AT lianyingsong differencesinthepathogeneticcharacteristicsofprostatecancerinthetransitionalandperipheralzonesandthepossiblemolecularbiologicalmechanisms AT wenfenggao differencesinthepathogeneticcharacteristicsofprostatecancerinthetransitionalandperipheralzonesandthepossiblemolecularbiologicalmechanisms AT xuyunwang differencesinthepathogeneticcharacteristicsofprostatecancerinthetransitionalandperipheralzonesandthepossiblemolecularbiologicalmechanisms AT yaoshengzhang differencesinthepathogeneticcharacteristicsofprostatecancerinthetransitionalandperipheralzonesandthepossiblemolecularbiologicalmechanisms AT yaoshengzhang differencesinthepathogeneticcharacteristicsofprostatecancerinthetransitionalandperipheralzonesandthepossiblemolecularbiologicalmechanisms |